{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:14:49Z","timestamp":1787015689538,"version":"build-2736575974"},"reference-count":40,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T00:00:00Z","timestamp":1682553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Small Animal Practice"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To review clinical characteristics, treatment, outcome and prognostic factors in dogs with solid cancer\u2010bearing bone metastases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Records were reviewed from dogs with histologically\u2010proven solid cancer and bone metastases. Clinicopathologic variables, bone metastases characteristics and skeletal\u2010related events were recorded. Endpoints were time to bone metastases and survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Fifty dogs were included, 20 of them with synchronous and 30 of them with metachronous bone metastases. In the latter group, median time to diagnosis of bone metastases was 210\u2009days (range, 30 to 1835). Most common primary cancer locations included mammary gland (n=6), spleen (n=5) and tonsil (n=5). Most common histotypes were carcinoma (n=32) and hemangiosarcoma (n=10). Nineteen dogs had multiple bones involvement, with humeri and vertebrae more commonly affected. Twenty\u2010four dogs received antitumoural therapy, five symptomatic treatment and 21 were not treated. Overall median survival after bone metastases diagnosis was 30\u2009days (range, 11 to 49); 83% of dogs died because of skeletal\u2010related events. Lack of antitumoural therapy was significantly associated with shorter survival (hazard ratio: 2.7; 95% confidence interval: 1.3 to 5.6) and with increased risk of skeletal\u2010related death (hazard ratio: 3.3; 95% confidence interval: 1.4 to 7.4). Dogs with endocrine\/neuroendocrine tumours (odds ratio: 8.8; 95% confidence interval: 1.2 to 63.9), without appendicular metastases (odds ratio: 5.1; 95% confidence interval: 1.0 to 25.8), without extra\u2010skeletal metastases (odds ratio: 5.2; 95% confidence interval: 1.1 to 24.5) and receiving antitumoural therapy (odds ratio: 14.8; 95% confidence interval: 1.7 to 131.4) had an increased chance of surviving more than 100\u2009days.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Significance<\/jats:title>\n                    <jats:p>Bone metastases in dogs with solid cancers are associated with poor prognosis and a high risk of skeletal\u2010related events. Treatment appears to have an impact on survival.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jsap.13621","type":"journal-article","created":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T04:34:40Z","timestamp":1682570080000},"page":"561-567","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["A retrospective study on bone metastasis in dogs with advanced\u2010stage solid cancer"],"prefix":"10.1111","volume":"64","author":[{"given":"C.","family":"Agnoli","sequence":"first","affiliation":[{"name":"Department of Veterinary Medical Sciences Alma Mater Studiorum University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7005-2736","authenticated-orcid":false,"given":"S.","family":"Sabattini","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medical Sciences Alma Mater Studiorum University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5704-6590","authenticated-orcid":false,"given":"A.","family":"Ubiali","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medical Sciences Alma Mater Studiorum University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Battisti","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medical Sciences Alma Mater Studiorum University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Rossi","sequence":"additional","affiliation":[{"name":"Clinica Veterinaria dell'Orologio  Sasso Marconi (BO) Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Diana","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medical Sciences Alma Mater Studiorum University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. T.","family":"Camerino","sequence":"additional","affiliation":[{"name":"Department of Veterinary Sciences University of Torino  Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Perfetti","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medical Sciences Alma Mater Studiorum University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Ciammaichella","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medical Sciences Alma Mater Studiorum University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2726-0366","authenticated-orcid":false,"given":"D.","family":"Stefanello","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine and Animal Sciences University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Papa","sequence":"additional","affiliation":[{"name":"Clinica Veterinaria Gran Sasso  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1186-5977","authenticated-orcid":false,"given":"R.","family":"Zaccone","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medical Sciences Alma Mater Studiorum University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7843-615X","authenticated-orcid":false,"given":"L.","family":"Marconato","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medical Sciences Alma Mater Studiorum University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,4,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300985816677152"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19971015)80:8 <1588::AID-CNCR9>3.0.CO;2-G"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1998.tb02124.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-59496-7.00025-6"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2005.tb02661.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2020.04.009"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-006-9029-8"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0030-5898(05)70171-1"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.5326\/15473317-31-4-321"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(02)01169-3"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/2309499020915989"},{"key":"e_1_2_8_13_1","first-page":"87","article-title":"Estimated number of prevalent cases of metastatic bone disease in the US adult population","volume":"4","author":"Li S.","year":"2012","journal-title":"Clinical Epidemiology"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1586\/ecp.12.35"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(20000301)88:5<1082::AID-CNCR20>3.0.CO;2-Z"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/vetsci6020048"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.4314\/ovj.v9i4.6"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/vms3.513"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.RLU.0000057556.54046.7A"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2622"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2010.03.034"},{"key":"e_1_2_8_22_1","first-page":"8","article-title":"Markers of bone turnover: biochemical and clinical perspectives","volume":"28","author":"Pagani F.","year":"2005","journal-title":"Journal of Endocrinological Investigation"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)49915-0"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-05-1806"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2014.04.002"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.22351"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2014.07.020"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra030831"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20308"},{"key":"e_1_2_8_30_1","first-page":"21","article-title":"Metastatic cancer in solid tumors and clinical outcome: skeletal\u2010related events","volume":"23","author":"Rove K. 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