{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:22:04Z","timestamp":1790727724592,"version":"4.1.0"},"reference-count":71,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,6,21]],"date-time":"2023-06-21T00:00:00Z","timestamp":1687305600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Small Animal Practice"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Pyometra is common in non\u2010spayed adult female dogs requiring early diagnosis and treatment to increase the survival rate. The diagnosis of pyometra is mainly based on clinical examination and anamnesis. Radiography, ultrasonography and laboratory analyses are recommended to support a diagnosis. The aim of this study was to assess blood parameters associated with pyometra by performing a systematic review and meta\u2010analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>The review was conducted in accordance with PRISMA guidelines. A search of three databases (PubMed, Google Scholar and CAB abstracts) was performed in July 2022. Studies providing information about laboratory parameters for both the pyometra group and healthy control group dogs were eligible for inclusion. Data extraction included the first author\u2019s name, publication year, country, number of participants in both groups, mean values of selected studies, standard deviation values, and blood parameters. The risk of bias for each study was evaluated, and a random\u2010effects meta\u2010analysis was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 44 studies which investigated 12 blood parameters. High heterogeneity was detected in all parameters in these meta\u2010analyses. The following blood parameters were increased in dogs with pyometra: white blood cell (mean=27.75\u00d710<jats:sup>9<\/jats:sup>\u2009L<jats:sup>\u22121<\/jats:sup>, mean difference (MD)=17.16, 95% confidence interval (CI) 14.85 to 19.47), monocytes (mean=2.06\u00d710<jats:sup>12<\/jats:sup>\/L, MD=1.37, 95% CI 0.99 to 1.74), blood urea nitrogen (mean=41.42\u2009mg\/dL MD=18.06, 95% CI 12.26 to 23.85), alkaline phosphatase (mean=212.78\u2009IU\/L, MD=137.51, 95% CI 81.81 to 88.62), and aspartate aminotransferase (mean=48.31\u2009IU\/L, MD=16.96, 95% CI 10.61 to 23.30). The following parameters were reduced: red blood cell (mean=5.42 10<jats:sup>12<\/jats:sup>\/L, MD=\u22121.37, 95% CI \u22121.68 to \u22121.05), haemoglobin (mean=121.20\u2009g\/L, MD=\u221230.57, 95% CI \u221239.70 to 21.45), albumin (mean=23.71\u2009g\/L, MD\u2009=\u2009\u22128.16, 95% CI \u221211.46 to \u22124.86). Lymphocyte, creatinine, urea, and alanine transaminase parameters were increased in some studies and decreased in others.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical Significance<\/jats:title><jats:p>In canine pyometra, some blood parameters are consistently increased, some consistently decreased, and some increased or decreased depending on the study.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jsap.13641","type":"journal-article","created":{"date-parts":[[2023,6,21]],"date-time":"2023-06-21T10:00:20Z","timestamp":1687341620000},"page":"543-551","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The assessment of haematologic and serum chemistry parameters in canine pyometra: a systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8901-713X","authenticated-orcid":false,"given":"A.","family":"Demeli","sequence":"first","affiliation":[{"name":"Genreal Directorate of Food and Control  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. C.","family":"Meyer","sequence":"additional","affiliation":[{"name":"Equine Sport Science  East Hampton New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,21]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"271","article-title":"Comparison of clinical and inflammatory parameters in dogs with pyometra before and after ovariohysterectomy","volume":"85","author":"Ahn S.","year":"2021","journal-title":"Canadian Journal of Veterinary Research"},{"key":"e_1_2_7_3_1","first-page":"53","volume-title":"K\u00f6pek ve Kedilerde \u00dcreme S\u00fcreci ve Sorunlar\u0131","author":"Ala\u00e7am E.","year":"2008"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.15312\/EurasianJVetSci.2020.280"},{"key":"e_1_2_7_5_1","volume-title":"Fakulteten f\u00f6r veterin\u00e4rmedicin och husdjursvetenskap Institutionen f\u00f6r Kliniska Vetenskaper","author":"Ambrosen A.","year":"2014"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.2307\/2533446"},{"key":"e_1_2_7_7_1","first-page":"103","article-title":"What does a hemogram say to us?","volume":"55","author":"Celkan T. 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