{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:38:43Z","timestamp":1747186723744,"version":"3.40.5"},"reference-count":20,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T00:00:00Z","timestamp":1687219200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Small Animal Practice"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:p>A 12\u2010year\u2010old neutered male Chihuahua dog was diagnosed with pituitary\u2010dependent hypercortisolism and treated with trilostane. Eighty\u2010nine days later, the dog showed lethargy accompanied by hyponatraemia and hyperkalaemia. Hypoadrenocorticism due to trilostane was suspected, but the result of the adrenocorticotropic hormone stimulation test was not conclusive. Contrast\u2010enhanced ultrasound showed loss of adrenocortical blood flow in both adrenal glands, indicating adrenocortical hypoperfusion and isolated hypoadrenocorticism. Treatment with fludrocortisone acetate improved the condition and electrolyte abnormalities. Thirteen months later, the dog showed alopecia, and an adrenocorticotropic hormone stimulation test revealed increased cortisol concentration, indicating hypercortisolism recurrence. The dog died due to progressive deterioration 22\u2009months after the initial presentation. <jats:italic>Post\u2010mortem<\/jats:italic> examination revealed focally extensive necrosis with marked calcification in the parenchyma of the adrenal glands and regeneration of the cells in the zona fasciculata with severe fibrosis. Adrenocortical hypoperfusion detected by contrast\u2010enhanced ultrasound can support the diagnosis of adrenal necrosis and hypoadrenocorticism.<\/jats:p>","DOI":"10.1111\/jsap.13643","type":"journal-article","created":{"date-parts":[[2023,6,21]],"date-time":"2023-06-21T05:51:00Z","timestamp":1687326660000},"page":"722-726","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Adrenocortical hypoperfusion detected by contrast\u2010enhanced ultrasound in a dog with trilostane\u2010induced hypoadrenocorticism"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8724-7537","authenticated-orcid":false,"given":"N.","family":"Nagata","sequence":"first","affiliation":[{"name":"Joint Department of Veterinary Medicine, Faculty of Applied Biological Sciences Gifu University  1\u20101 Yanagido Gifu 501\u20101193 Japan"},{"name":"Veterinary Teaching Hospital, Faculty of Veterinary Medicine Hokkaido University  Kita 18, Nishi 9, Kita\u2010ku Sapporo 060\u20100818 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Aoshima","sequence":"additional","affiliation":[{"name":"Laboratory of Comparative Pathology, Department of Clinical Sciences, Faculty of Veterinary Medicine Hokkaido University  Kita 18, Nishi 9, Kita\u2010ku Sapporo 060\u20100818 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1010-3228","authenticated-orcid":false,"given":"K.","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Internal Medicine, Department of Clinical Sciences, Faculty of Veterinary Medicine Hokkaido University  Kita 18, Nishi 9, Kita\u2010ku Sapporo 060\u20100818 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Takiguchi","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Internal Medicine, Department of Clinical Sciences, Faculty of Veterinary Medicine Hokkaido University  Kita 18, Nishi 9, Kita\u2010ku Sapporo 060\u20100818 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,6,20]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/vru.12018"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.5326\/JAAHA-MS-6363"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/vru.12404"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.domaniend.2010.10.002"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.2004.tb00241.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.12268"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.234.4.460"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.15604"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2017.10.018"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-5616(97)50033-7"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.20-0427"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2011.01823.x"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.74.3.417"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.75.10.886"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/vru.12285"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-0813.2008.00373.x"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-7125(16)30087-6"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.160.7.219"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2018.09.014"},{"key":"e_1_2_5_21_1","first-page":"407","article-title":"Ketoconazole\u2010induced transient hypoadrenocorticism in a dog","volume":"61","author":"Sullivant A. 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