{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T15:40:03Z","timestamp":1731080403184,"version":"3.28.0"},"reference-count":62,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,1,19]],"date-time":"2024-01-19T00:00:00Z","timestamp":1705622400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Small Animal Practice"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the safety and efficacy of human intravenous immunoglobulin in dogs with newly diagnosed malignancy and presumed secondary immune\u2010mediated thrombocytopenia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Twelve client\u2010owned dogs with newly diagnosed malignant disease and presumed secondary immune\u2010mediated thrombocytopenia were prospectively enrolled to receive a single infusion of human intravenous immunoglobulin at a dose of 0.5 to 1\u2009mg\/kg intravenous over 8\u2009hours. A complete treatment response was defined as a platelet estimation of \u226540,000 platelets\/\u03bcL within 24\u2009hours and a partial response within 48\u2009hours from the completion of human intravenous immunoglobulin infusion. No treatment response was defined as a platelet estimation remaining &lt;40,000 platelets\/\u03bcL over 48\u2009hours from the completion of the human intravenous immunoglobulin infusion. This pilot study had a prospective, open\u2010label, uncontrolled design.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Out of the 12 enrolled dogs, seven completed the study. A complete treatment response to human intravenous immunoglobulin was identified in one lymphoma dog and a partial response was noted in another lymphoma dog. The remaining 10 dogs had no response to human intravenous immunoglobulin. No clinically relevant adverse reactions to human intravenous immunoglobulin occurred in any of the 12 initially enrolled dogs during the infusion and over a 3\u2010month follow\u2010up period for the seven surviving dogs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical Significance<\/jats:title><jats:p>The results of this study suggest that the use of human intravenous immunoglobulin in dogs with newly diagnosed malignant disease and presumed secondary immune\u2010mediated thrombocytopenia appears safe, but not effective for the treatment of thrombocytopenia. Larger multi\u2010centre, prospective, double\u2010blinded, placebo\u2010controlled, outcome\u2010based, malignancy\u2010specific studies are needed to further evaluate these preliminary findings.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jsap.13700","type":"journal-article","created":{"date-parts":[[2024,1,19]],"date-time":"2024-01-19T08:24:33Z","timestamp":1705652673000},"page":"338-345","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Use of human intravenous immunoglobulin for the treatment of 12 dogs with newly diagnosed malignant disease and presumed secondary immune\u2010mediated thrombocytopenia"],"prefix":"10.1111","volume":"65","author":[{"given":"E.","family":"Stikeman","sequence":"first","affiliation":[{"name":"Internal Medicine Department, Metropolitan Animal Specialty Hospital 6565 Santa Monica Boulevard Los Angeles CA 90038 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Bianco","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Metropolitan Animal Specialty Hospital 6565 Santa Monica Boulevard Los Angeles CA 90038 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,1,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1154315"},{"key":"e_1_2_8_3_1","first-page":"535","article-title":"Human intravenous immunoglobulin for the treatment of immune\u2010mediated thrombocytopenia in dog \u2013 case report","volume":"7","author":"Back F.P.","year":"2013","journal-title":"Acta Veterinaria Brasilica"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19910915)68:6 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