{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T05:21:37Z","timestamp":1771305697195,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T00:00:00Z","timestamp":1707868800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Small Animal Practice"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Determine comparative tolerance of daily oral and weekly parenteral cobalamin supplementation, in hypocobalaminaemic dogs with chronic enteropathy. Determine whether oral is as effective as parenteral supplementation at achieving eucobalaminaemia, in hypocobalaminaemic dogs with protein\u2010losing enteropathy, severe hypocobalaminaemia or high canine inflammatory bowel disease activity index at inclusion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Thirty\u2010seven client\u2010owned dogs with hypocobalaminaemia and clinical signs of chronic enteropathy were prospectively enrolled in three UK referral centres. Dogs were randomly allocated to daily oral for 12\u2009weeks or weekly parenteral cobalamin supplementation for 6\u2009weeks and one additional dose 4\u2009weeks later. Serum cobalamin, body condition score, canine inflammatory bowel disease activity index and bodyweight were assessed at inclusion, weeks 7 and 13. Serum methylmalonic acid concentration was evaluated at inclusion and at week 13. Owners completed treatment adherence, palatability, tolerance and satisfaction questionnaires at week 13.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nineteen dogs completed the study. All dogs orally supplemented achieved normal or increased cobalaminaemia at weeks 7 and 13. There was no statistical difference in cobalamin concentration at week 13 in dogs treated with oral or parenteral supplementation, regardless of presence of protein\u2010losing enteropathy, severity of hypocobalaminaemia or canine inflammatory bowel disease activity index at inclusion. Serum methylmalonic acid concentration was not significantly different between oral and parenteral groups, neither were treatment adherence, satisfaction, and tolerance scores at week 13.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical Significance<\/jats:title><jats:p>Oral is as effective and as well\u2010tolerated as parenteral cobalamin supplementation in hypocobalaminaemic dogs with chronic enteropathy and severe clinical or biochemical phenotypes, and should be considered as a suitable treatment option regardless of disease severity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jsap.13705","type":"journal-article","created":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T23:18:40Z","timestamp":1707952720000},"page":"317-328","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Efficacy and tolerance of oral <i>versus<\/i> parenteral cyanocobalamin supplement in hypocobalaminaemic dogs with chronic enteropathy: a controlled randomised open\u2010label trial"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8549-4553","authenticated-orcid":false,"given":"C.","family":"Dor","sequence":"first","affiliation":[{"name":"Department of Veterinary Medicine and Science University of Nottingham  Nottingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Nixon","sequence":"additional","affiliation":[{"name":"ADM Protexin Ltd  Lopen Head Somerset UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1084-7013","authenticated-orcid":false,"given":"S.","family":"Salavati Schmitz","sequence":"additional","affiliation":[{"name":"The Royal (Dick) School of Veterinary Studies and the Roslin Institute The Hospital for Small Animals, University of Edinburgh  Edinburgh UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Bazelle","sequence":"additional","affiliation":[{"name":"Davies Veterinary Specialists Manor Farm Business Park  Hitchin Hertfordshire UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"\u010cern\u00e1","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences Colorado State University  Fort Collins CO USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Kilpatrick","sequence":"additional","affiliation":[{"name":"Idexx Laboratories, Grange House  Sandbeck Way Wetherby West Yorkshire UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. 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