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All dogs were premedicated with methadone and 2 to 6\u2009mcg\/kg dexmedetomidine subcutaneously. They were induced and maintained on a standard protocol. All animals received a second dose of methadone subcutaneously 4\u2009hours after premedication and a 4.4\u2009mg\/kg dose of carprofen subcutaneously at 8\u2009hours after premedication. During surgery, blood pressure, heart rate and temperature were assessed every 5\u2009minutes. Postoperatively, sedation scores, temperature, heart rate and Glasgow composite modified pain score \u2013 short form were assessed for 12\u2009hours postoperatively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One of 17 (5.9%) dogs had intraoperative hypotension, nine of 17 dogs had intra\u2010operative bradyarrhythmias and 17 of 17 dogs had intra\u2010operative hypothermia. No dogs required intra\u2010operative rescue. Composite modified pain score \u2013 short form scores were below the threshold for intervention in 16 of 17 (94.1%) animals. Only one of 17 (5.9%) dogs required rescue analgesia. Median sedation score was 0 by the T8 time point. Adverse events were rare in both groups with only vocalisation and hypothermia reported commonly postoperatively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical Significance<\/jats:title><jats:p>Two doses of methadone at either 0.25 or 0.5\u2009mg\/kg administered via subcutaneous injections pre\u2010operatively and 4\u2009hours later, along with 4.4\u2009mg\/kg carprofen subcutaneously 8\u2009hours after the first methadone dose appear to provide sufficient pain control for up to 12\u2009hours in dogs undergoing tibial plateau levelling osteotomy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jsap.13728","type":"journal-article","created":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T04:43:30Z","timestamp":1712724210000},"page":"368-375","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Two doses of subcutaneous methadone for postoperative analgesia in dogs undergoing tibial plateau levelling osteotomies"],"prefix":"10.1111","volume":"65","author":[{"given":"D.","family":"Upchurch","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine Kansas State University  Manhattan KS 66506 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. 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