{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T17:12:00Z","timestamp":1784308320932,"version":"3.55.0"},"reference-count":41,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T00:00:00Z","timestamp":1715817600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Small Animal Practice"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Studies in humans have demonstrated the role of <jats:italic>Toxoplasma gondii<\/jats:italic>, a protozoan parasite, in epileptic seizures. This study aimed to investigate the serological correlation between <jats:italic>T. gondii<\/jats:italic> and <jats:italic>N. caninum<\/jats:italic> and epilepsy in dogs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>The medical record database of the Veterinary Teaching Hospital, University of Perugia, was searched for dogs\u00a0serologically tested by IFAT for <jats:italic>T. gondii<\/jats:italic> and <jats:italic>N. caninum<\/jats:italic> and following specific inclusion criteria. Dogs were stratified by having a clinical diagnosis of epilepsy or suffering different conditions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One\u2010hundred and twenty\u2010eight dogs were included, 64 with epilepsy and 64 without clinical signs of epilepsy. Seventeen of the 64 epileptic dogs (26.6%; 95% CI: 15.7% to 37.4%) and twenty\u2010one of the 64 non\u2010epileptic dogs (32.8%; 95% CI: 21.3% to 44.3%) tested positive for <jats:italic>T. gondii<\/jats:italic>. Eight of the epileptic dogs (12.5%; 95% CI: 4.4% to 20.6%) and three of the non\u2010epileptic dogs (4.7%; 95% CI: 0% to 9.9%) tested positive for <jats:italic>N. caninum<\/jats:italic>. There was no statistically significant difference in the rate of <jats:italic>T. gondii<\/jats:italic> or <jats:italic>N. caninum<\/jats:italic> seroreactivity between epileptic and non\u2010epileptic dogs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical Significance<\/jats:title><jats:p>The results obtained do not seem to support the role of <jats:italic>T. gondii<\/jats:italic> and <jats:italic>N. caninum<\/jats:italic> as causative agents of dog epilepsy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jsap.13735","type":"journal-article","created":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T06:54:51Z","timestamp":1715928891000},"page":"631-636","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["<i>Toxoplasma gondii<\/i> and <i>Neospora caninum<\/i> infection in epileptic dogs"],"prefix":"10.1111","volume":"65","author":[{"given":"G.","family":"Morganti","sequence":"first","affiliation":[{"name":"Department of Veterinary Medicine University of Perugia  Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Rigamonti","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine University of Perugia  Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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