{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:38:56Z","timestamp":1747186736864,"version":"3.40.5"},"reference-count":37,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T00:00:00Z","timestamp":1720051200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Small Animal Practice"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>This retrospective cohort multicentre study aimed to characterise the signalment, clinicopathologic data, complications and the association between treatment and outcome (the reduction in ionised calcium concentration) in cats with idiopathic or chronic kidney disease\u2010associated ionised hypercalcaemia managed with alendronate and standard treatment or standard treatment alone, and to compare the outcome between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Medical records for cats diagnosed with idiopathic or chronic kidney disease\u2010associated ionised hypercalcaemia were retrospectively reviewed. Cats treated with alendronate and standard treatment were assigned to the alendronate group and cats treated with standard treatment alone were assigned to the control group. The standard treatment was defined as dietary modification and\/or monitoring of ionised calcium concentrations and management of complications secondary to hypercalcaemia. The follow\u2010up period was selected as 6\u2009months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010nine cats were enrolled in the study. Nine cats were included in the control group and 20 cats in the alendronate group. A significant reduction in serum ionised calcium was observed in both groups between the baseline and the follow\u2010up visit; however, this reduction did not differ significantly between both groups (the mean change in the ionised calcium concentration in alendronate and control group was \u22120.18 and \u22120.17, respectively). Suspected bisphosphate\u2010related osteonecrosis of the jaw was reported in one cat receiving alendronate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical Significance<\/jats:title><jats:p>In this study, similar reduction in serum ionised calcium concentration was observed in cats with ionised hypercalcaemia treated with diet alone and in cats treated with diet and alendronate. These results should be interpreted with caution, as the study was underpowered for meaningful statistical comparison. Cats receiving alendronate should be monitored for the development of adverse reactions, including osteonecrosis of the jaw.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jsap.13755","type":"journal-article","created":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T07:01:55Z","timestamp":1720076515000},"page":"682-693","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Assessment of alendronate and dietary treatment in the management of feline idiopathic ionised hypercalcaemia and ionised hypercalcaemia associated with chronic kidney disease: 29 cases (2016\u20102022)"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0572-2646","authenticated-orcid":false,"given":"U.","family":"Rzeszutek","sequence":"first","affiliation":[{"name":"Davies Veterinary Specialists  Shillington UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Allerton","sequence":"additional","affiliation":[{"name":"Willows Veterinary Specialists  Solihull UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Au","sequence":"additional","affiliation":[{"name":"Eastcott Veterinary Hospital  Swindon UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Bras","sequence":"additional","affiliation":[{"name":"North Downs Specialist Referrals  Bletchingley UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Briggs","sequence":"additional","affiliation":[{"name":"Langford Vets  Langford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Broome","sequence":"additional","affiliation":[{"name":"University of Liverpool Small Animal Teaching Hospital  Liverpool UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Gamston","sequence":"additional","affiliation":[{"name":"Dick White Referrals  Six Mile Bottom UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Parton","sequence":"additional","affiliation":[{"name":"Wear Referrals  Bradbury UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Raj","sequence":"additional","affiliation":[{"name":"Southfields Veterinary Specialists  Basildon UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. M.","family":"Rossell","sequence":"additional","affiliation":[{"name":"Northwest Veterinary Specialists  Runcorn UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0205-4678","authenticated-orcid":false,"given":"O.","family":"Russell","sequence":"additional","affiliation":[{"name":"University of Cambridge Queen's Veterinary School Hospital  Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4382-7051","authenticated-orcid":false,"given":"T.","family":"Sparks","sequence":"additional","affiliation":[{"name":"Waltham Petcare Science Institute  Waltham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6372-6875","authenticated-orcid":false,"given":"J.","family":"Bazelle","sequence":"additional","affiliation":[{"name":"Davies Veterinary Specialists  Shillington UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,7,4]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/JBMR.3420"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2008.01.038"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198\u2010010\u20101268\u20104"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.12378"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.253.10.1309"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2016.09.004"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/JVIM.14643"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/JVIM.16430"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/JVIM.16627"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601\u20106343.2009.01456.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781118997093.ch35"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/2055116917727137"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X241229811"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2020.00421"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X16643248"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.TVJL.2018.02.010"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.16050"},{"key":"e_1_2_6_19_1","first-page":"319","volume-title":"Feline endocrinology","author":"Graves T.K.","year":"2019"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.12507"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1892\/0891\u20106640(2005)19\u27e829:uaeopd\u27e92.0.co;2"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocd.2016.09.005"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0195\u20105616(96)50135\u2010X"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/JVIM.16508"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.15409"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03026321"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1892\/0891\u20106640(2000)014<0619:ihic>2.3.co;2"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1210\/JC.2004\u20100952"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X15581134"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/vetreccr\u20102018\u2010000798"},{"key":"e_1_2_6_31_1","unstructured":"Sayyid M. Gilor C. Parker V.J. Rudynsky A.&Chew D.J.(2016)Ionized hypercalcemia in cats: etiologies and associated clinical signs.2016 ACVIM Forum Research Abstract Program. Denver CO."},{"key":"e_1_2_6_32_1","unstructured":"Schenck P.(2008)Annual ACVIM forum San Antonio.Serum ionized magnesium concentrations in association with feline calcium metabolic disorders. San Antonio 796."},{"key":"e_1_2_6_33_1","first-page":"209","article-title":"Prediction of serum ionized calcium concentration by serum total calcium measurement in cats","volume":"74","author":"Schenck P.A.","year":"2010","journal-title":"Canadian Journal of Veterinary Research"},{"key":"e_1_2_6_34_1","article-title":"Calcium metabolic hormones in feline idiopathic hypercalcemia","volume":"18","author":"Schenck P.A.","year":"2004","journal-title":"Journal of Veterinary Internal Medicine"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.5326\/JAAHA\u2010MS\u20106681"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.253"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2020.115711"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfms.2010.09.011"}],"container-title":["Journal of Small Animal Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jsap.13755","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T09:53:25Z","timestamp":1732096405000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jsap.13755"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,4]]},"references-count":37,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1111\/jsap.13755"],"URL":"https:\/\/doi.org\/10.1111\/jsap.13755","archive":["Portico"],"relation":{},"ISSN":["0022-4510","1748-5827"],"issn-type":[{"type":"print","value":"0022-4510"},{"type":"electronic","value":"1748-5827"}],"subject":[],"published":{"date-parts":[[2024,7,4]]},"assertion":[{"value":"2023-05-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}