{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T00:16:29Z","timestamp":1782519389523,"version":"3.54.5"},"reference-count":44,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T00:00:00Z","timestamp":1736899200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Small Animal Practice"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To describe the clinical presentation and clinicopathological findings of dogs with nodular splenic lesions composed of heterogeneous cell components associated with systemic inflammation and to provide information on the outcome after surgical resection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Medical records were searched for dogs with histologically and immunohistochemically characterised nodular splenic lesions with mixed stromal, histiocytic and lymphoid cells and the presence of systemic inflammatory markers at the time of diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Four dogs were included, of which three had an undifferentiated splenic stromal sarcoma and one had a splenic leiomyosarcoma. Fever and abdominal pain were reported in three and four cases, respectively. All dogs showed hyperglobulinaemia and marked changes in the serum protein electrophoresis profile. C\u2010reactive protein and fibrinogen concentrations were both increased in three cases. These abnormalities completely resolved after splenectomy. Moreover, two dogs had concomitant glomerular disease and one dog had liver amyloidosis. Three dogs were still alive and asymptomatic 1, 6 and 9\u2009months after surgery. One dog died 16\u2009months after the initial presentation due to complications related to progressive renal failure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical Significance<\/jats:title><jats:p>Based on this report, nodular splenic lesions with heterogeneous cell components may directly be associated with a pro\u2010inflammatory state and should be considered as part of the differential diagnosis of fever and hyperglobulinaemia in dogs. Furthermore, early recognition and treatment of these lesions could reduce the risk of systemic complications potentially associated with amyloid deposit and organ failure.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jsap.13826","type":"journal-article","created":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T00:03:10Z","timestamp":1736985790000},"page":"280-290","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Acute and chronic systemic inflammation associated with canine nodular splenic lesions composed of heterogeneous cell components: four cases (2020\u20102024)"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-1815-3836","authenticated-orcid":false,"given":"K.","family":"Mourou","sequence":"first","affiliation":[{"name":"Service de M\u00e9decine Interne, D\u00e9partement des Animaux de Compagnie de Loisir et de Sport Universit\u00e9 de Lyon, VetAgro Sup, Campus V\u00e9t\u00e9rinaire de Lyon  Marcy\u2010l'\u00c9toile France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Abou Monsef","sequence":"additional","affiliation":[{"name":"Laboratoire d'Histopathologie V\u00e9t\u00e9rinaire, Universit\u00e9 de Toulouse, \u00c9cole Nationale V\u00e9t\u00e9rinaire de Toulouse  Toulouse Cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Belluco","sequence":"additional","affiliation":[{"name":"Laboratoire d'Histopathologie V\u00e9t\u00e9rinaire, VetAgro Sup, Campus V\u00e9t\u00e9rinaire  Marcy l'\u00e9toile France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Penent","sequence":"additional","affiliation":[{"name":"Laboratoire d'Histopathologie V\u00e9t\u00e9rinaire, Universit\u00e9 de Toulouse, \u00c9cole Nationale V\u00e9t\u00e9rinaire de Toulouse  Toulouse Cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Delverdier","sequence":"additional","affiliation":[{"name":"Laboratoire d'Histopathologie V\u00e9t\u00e9rinaire, Universit\u00e9 de Toulouse, \u00c9cole Nationale V\u00e9t\u00e9rinaire de Toulouse  Toulouse Cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Hugonnard","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Interne, D\u00e9partement des Animaux de Compagnie de Loisir et de Sport Universit\u00e9 de Lyon, VetAgro Sup, Campus V\u00e9t\u00e9rinaire de Lyon  Marcy\u2010l'\u00c9toile France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Granat","sequence":"additional","affiliation":[{"name":"Laboratoire Central de Biologie M\u00e9dicale, ENVT  Toulouse France"},{"name":"METAML, CRCT, Inserm, ENVT  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Lavoue","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Toulouse  Toulouse France"},{"name":"INTHERES, Universit\u00e9 de Toulouse, INRA, ENVT, UPS  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Mantelli","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Toulouse  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.240.9.1088"},{"key":"e_1_2_7_3_1","first-page":"1","article-title":"Estudo casu\u00edstico retrospectivo de neoforma\u00e7\u00f5es prim\u00e1rias espl\u00eanicas [Retrospective case study of primary splenic neoformations]","volume":"10","author":"Backschat P.S.","year":"2012","journal-title":"Revista Cient\u00edfica de Medicina Veterin\u00e1ria"},{"key":"e_1_2_7_4_1","first-page":"161","article-title":"Comparison of serum amyloid A and C\u2010reactive protein as diagnostic markers of systemic inflammation in dogs","volume":"55","author":"Christensen M.B.","year":"2014","journal-title":"The Canadian Veterinary Journal"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani14050802"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1989.tb00326.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mimet.2007.01.010"},{"key":"e_1_2_7_8_1","first-page":"250","article-title":"Splenic masses in dogs. 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