{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:35:24Z","timestamp":1791995724489,"version":"4.4.0"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T00:00:00Z","timestamp":1738108800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Small Animal Practice"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The objectives of this study were to describe the outcome and prognostic factors in dogs diagnosed with primary and secondary immune thrombocytopenia (ITP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Medical records of dogs diagnosed with primary and secondary ITP in a referral hospital in Ireland were retrospectively evaluated. Short\u2010 and long\u2010term survivals were analysed using Cox proportional\u2010hazards regression models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Medical records from 49 dogs were included. Primary and secondary ITP were diagnosed in 81.25% and 18.75% of dogs, respectively. The survival rate was 69% at 2\u2009weeks (95% confidence interval [CI]: 0.54 to 0.80), 63% at 3\u2009months (95% CI: 0.48 to 0.75) and 51% at 2\u2009years (95% CI: 0.37 to 0.65). The overall median survival time was 985\u2009days (primary ITP only: 1084\u2009days; secondary ITP only: 225\u2009days). Dogs surviving 30\u2009days post\u2010diagnosis had a median long\u2010term survival time of 10\u2009years. A lower haematocrit was negatively associated with survival [hazard ratio (HR) 0.96, 95% CI: 0.92 to 0.99]. Neutrophilia (HR: 0.44, 95% CI: 0.20 to 0.96) was associated with a 66% decreased risk of death. Band neutrophilia was associated with shorter hospitalisation (regression coefficient\u2009\u22123.56, 95% CI: \u22125.70 to \u20101.42). Presence of petechiae and ecchymoses (regression coefficient 2.41, 95% CI: 0.41 to 4.42), and the use of a second\u2010line immunosuppressive agent (SLI) (regression coefficient 2.11, 95% CI: 0.11 to 4.12) were significantly associated with longer hospitalisation but not with survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Significance<\/jats:title>\n                    <jats:p>A lower haematocrit was the only variable associated with a worse prognosis in dogs diagnosed with ITP. Dogs with confirmed secondary ITP had an overall shorter median survival time. Dogs surviving over 30\u2009days had an excellent prognosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jsap.13833","type":"journal-article","created":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T18:28:22Z","timestamp":1738175302000},"page":"305-313","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Prognostic factors and long\u2010term outcome in dogs diagnosed with primary and secondary immune thrombocytopenia in Ireland"],"prefix":"10.1111","volume":"66","author":[{"given":"E.","family":"L\u00f3pez\u2010Bail\u00e9n","sequence":"first","affiliation":[{"name":"Langford Vets Small Animal Hospital  Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8957-6108","authenticated-orcid":false,"given":"A.","family":"Duclos","sequence":"additional","affiliation":[{"name":"Small Animal Clinical Studies UCD School of Veterinary Medicine  Dublin 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