{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T22:50:47Z","timestamp":1787871047973,"version":"build-2784847793"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T00:00:00Z","timestamp":1739404800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Small Animal Practice"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      The primary objective of this study was to evaluate viscoelastic profiles in heartworm antigen\u2010positive\n                      <jats:italic>versus<\/jats:italic>\n                      antigen\u2010negative dogs using a point\u2010of\u2010care viscoelastic device. A secondary objective was to compare intraoperative bleeding and surgical duration between these same groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      Dogs presented for elective surgical gonadectomy were screened for the presence of heartworm antigen using a commercial antigen detection test. Viscoelastic testing was performed in equal numbers of asymptomatic heartworm antigen\u2010positive and \u2010negative dogs. Viscoelastic data recorded included Clot Time, Clot Formation Time, \u03b1\u2010angle, Maximum Clot Formation, Amplitude at 10\u2009minutes (A10), Amplitude at 20\u2009minutes (A20), Lysis Index at 30 minutes (LI30) and Lysis Index at 45 minutes (LI45). Other data included intraoperative blood loss\n                      <jats:italic>via<\/jats:italic>\n                      the gravimetric technique and surgical time (incision to closure).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 60 dogs (30 heartworm antigen\u2010negative and 30 heartworm antigen\u2010positive) were enrolled in the study. There were no significant differences between Clot Time, Clot Formation Time, \u03b1\u2010angle, LI30 and LI45 between heartworm antigen\u2010positive and \u2010negative dogs; however, Maximum Clot Formation, A10 and A20 were higher in heartworm antigen\u2010positive dogs. All viscoelastic results were within previously published normal reference ranges. No significant differences in surgical gonadectomy duration or intraoperative blood loss were observed between groups for male or female dogs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Significance<\/jats:title>\n                    <jats:p>Apparently healthy heartworm antigen\u2010positive dogs were relatively hypercoagulable as defined by viscoelastic testing compared to heartworm antigen\u2010negative dogs. There was no apparent additional risk of bleeding in dogs with subclinical heartworm infection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jsap.13834","type":"journal-article","created":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T05:03:52Z","timestamp":1739423032000},"page":"314-320","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Comparison of viscoelastic coagulation parameters, blood loss and surgical time between asymptomatic heartworm antigen\u2010positive and negative dogs presented for elective gonadectomy"],"prefix":"10.1111","volume":"66","author":[{"given":"B. K.","family":"Newmans","sequence":"first","affiliation":[{"name":"Ryan Veterinary Hospital, University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8945-0371","authenticated-orcid":false,"given":"J. 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