{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T02:40:02Z","timestamp":1750041602347,"version":"3.41.0"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T00:00:00Z","timestamp":1741651200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Small Animal Practice"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare the effect of acepromazine on surgical duration and complication rate when compared to medetomidine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>A randomised, prospective clinical study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animal or Sample Population<\/jats:title><jats:p>Thirty\u2010two female entire dog.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010two female entire dogs undergoing elective laparoscopic ovariectomy (lap\u2010ove). Dogs were randomly assigned to pre\u2010medication Group M (medetomidine, <jats:italic>n<\/jats:italic>\u2009=\u200920), or Group A (acepromazine, <jats:italic>n<\/jats:italic>\u2009=\u200912). Anaesthesia protocol was standardised and monitored by one anaesthetist. The surgeons were blinded for the group allocation. Time was recorded at predetermined intra\u2010operative points. Surgical difficulty was subjectively assessed intra\u2010operatively, as well as objectively scored following review of the surgical recordings. Procedural complications were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean\u2009\u00b1\u2009SD surgical time from skin incision to removal of both ovaries was 11.8\u2009\u00b1\u20091.8\u2009minutes and did not differ significantly between the two groups (M: 11.7\u2009\u00b1\u20091.6, A: 11.9\u2009\u00b1\u20092.3). Across the entire study population surgical difficulty was assessed as \u2018easy\u2019 in 14 dogs (44%), \u2018medium\u2019 difficulty in 14 dogs (44%) and \u2018marked\u2019 difficulty in four dogs (12%), while complication rate was 12.5% in both groups. There were no significant differences in difficulty or complication rate between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Choice of pre\u2010medication did not significantly affect any of the outcomes measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical Significance<\/jats:title><jats:p>Acepromazine may be used for sedation as part of a balanced premedication protocol as an alternative to medetomidine in dogs undergoing laparoscopic ovariectomy without significantly increasing the procedure time, surgical difficulty or complication rate.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jsap.13835","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T12:09:42Z","timestamp":1741694982000},"page":"389-395","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Influence of acepromazine vs. medetomidine on surgical time and complication rate during canine laparoscopic ovariectomy"],"prefix":"10.1111","volume":"66","author":[{"given":"R.","family":"Rennick","sequence":"first","affiliation":[{"name":"Nutgrove Veterinary Hospital  Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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