{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T11:01:08Z","timestamp":1790074868059,"version":"4.0.1"},"reference-count":44,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T00:00:00Z","timestamp":1740009600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Small Animal Practice"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aims of this study were to evaluate the response rate, time to progression (TTP) and survival times of dogs with high\u2010risk adrenal gland tumours (ATs) treated with toceranib phosphate, in both macroscopic and microscopic setting, and to report the adverse event (AE) profiles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Medical records of dogs diagnosed with a high\u2010risk adrenocortical carcinoma (ACC) or phaeochromocytoma (PCC), treated with toceranib, were retrospectively reviewed. High\u2010risk ATs were defined as inoperable and\/or metastatic ATs or cortical tumours with high Utrecht score. Endpoints were response rate, TTP and overall progression\u2010free survival time (PFST). Adverse events were reported according to VCOG\u2010CTCAE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixteen dogs were included: 10 diagnosed with PCC and six with ACC. All dogs with ACC received adjuvant toceranib due to a high Utrecht score or metastatic disease, while all dogs with PCC were treated with toceranib in the macroscopic setting. A clinical benefit was detected in 80% of dogs with PCC: four achieved stable disease for a median TTP of 176.5\u2009days, and two achieved partial response for 182 and\u2009&gt;100\u2009days, respectively. Median PFST for dogs with PCC was 112\u2009days. Among dogs with ACC, 3 (50%) progressed and were euthanized after 237, 364 and 273\u2009days; the remaining 3 (50%) dogs were alive and disease free 382, 508 and 583\u2009days after starting toceranib. Overall, toceranib was well\u2010tolerated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical Significance<\/jats:title><jats:p>Toceranib may offer clinical benefit and improve outcome in dogs with high\u2010risk ATs in both the macroscopic and microscopic disease setting.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jsap.13840","type":"journal-article","created":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T08:11:06Z","timestamp":1740039066000},"page":"412-419","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Toceranib phosphate for the treatment of dogs with high\u2010risk adrenal gland tumours: 16 cases (2019\u20102023)"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3062-4303","authenticated-orcid":false,"given":"C.","family":"Chalfon","sequence":"first","affiliation":[{"name":"Centro Veterinario Torinese  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7843-615X","authenticated-orcid":false,"given":"L.","family":"Marconato","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medical Sciences University of Bologna  Ozzano dell'Emilia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Galac","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Faculty of Veterinary Medicine Utrecht University  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3636-0415","authenticated-orcid":false,"given":"A. M.","family":"Tardo","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medical Sciences University of Bologna  Ozzano dell'Emilia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Zandvliet","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Faculty of Veterinary Medicine Utrecht University  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3121-2199","authenticated-orcid":false,"given":"F.","family":"Fracassi","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medical Sciences University of Bologna  Ozzano dell'Emilia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5577-0657","authenticated-orcid":false,"given":"F.","family":"Del Baldo","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medical Sciences University of Bologna  Ozzano dell'Emilia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Ghisoni","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medical Sciences University of Bologna  Ozzano dell'Emilia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Pisoni","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medical Sciences University of Bologna  Ozzano dell'Emilia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1932-211X","authenticated-orcid":false,"given":"R.","family":"Finotello","sequence":"additional","affiliation":[{"name":"Polo Oncologico Veterinario, AniCura Italy Holding S.r.l.  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/00480169.2021.1905569"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.5326\/15473317-37-1-93"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.12303"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.242.12.1715"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1997.tb00464.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.15335"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/vcp.12161"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2023.1156801"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12587"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.667798"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.244.10.1181"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2021.635057"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.5326\/JAAHA\u2010MS\u20106751"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.23.12.0689"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12799"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12291"},{"key":"e_1_2_8_18_1","first-page":"279","article-title":"C\u2010kit, flt\u20103, PDFGR\u2010\u03b2, and VEGFR2 expression in canine adrenal tumours and correlation with outcome following adrenalectomy","volume":"85","author":"Harding K.","year":"2021","journal-title":"Canadian Journal of Veterinary Research"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.15706"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2008.0182.x"},{"key":"e_1_2_8_21_1","first-page":"1059","article-title":"Retrospective evaluation of toceranib (Palladia) treatment for canine metastatic appendicular osteosarcoma","volume":"58","author":"Kim C.","year":"2017","journal-title":"Canadian Veterinary Journal"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-1419"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2011.00027"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2003.223.654"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1354\/vp.41-5-490"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.5326\/JAAHA-MS-5669"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12491"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5829.2011.00275.x"},{"key":"e_1_2_8_29_1","first-page":"2755","article-title":"Phase I dose\u2010escalating study of SU11654, a small molecule receptor tyrosine kinase inhibitor, in dogs with spontaneous malignancies","volume":"9","author":"London C.A.","year":"2003","journal-title":"Clinical Cancer Research"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-59496-7.00026-8"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.239.2.216"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/vsu.13221"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12917\u2010018\u20101597\u20107"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12032"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12571"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/vro2.27"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12917-016-0895-1"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.16371"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/vsu.12552"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4557-4456-5.00013-4"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12474"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.232.1.77"},{"key":"e_1_2_8_43_1","first-page":"99","article-title":"A comparision of outcomes between laparoscopic and open adrenalectomies in dogs","volume":"1","author":"Taylor C.J.","year":"2021","journal-title":"Veterinary Surgery"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.23.06.0324"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.283"}],"container-title":["Journal of Small Animal Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jsap.13840","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T02:07:13Z","timestamp":1750039633000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jsap.13840"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,20]]},"references-count":44,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1111\/jsap.13840"],"URL":"https:\/\/doi.org\/10.1111\/jsap.13840","archive":["Portico"],"relation":{},"ISSN":["0022-4510","1748-5827"],"issn-type":[{"value":"0022-4510","type":"print"},{"value":"1748-5827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,20]]},"assertion":[{"value":"2024-03-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}