{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:29:10Z","timestamp":1753878550632,"version":"3.41.2"},"reference-count":25,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,3,16]],"date-time":"2025-03-16T00:00:00Z","timestamp":1742083200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Small Animal Practice"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:p>Pathological bone fractures may occur secondarily to Cushing's syndrome in people. Although low bone mineral density due to cortisol excess has been described in dogs, there is no evidence that dogs with Cushing's disease can develop osteoporosis or secondary bone fractures. Here, we report a case of a dog with Cushing's disease and multiple pathological bone fractures. A 14\u2010year\u2010old female spayed mixed\u2010breed dog was attended due to progressive lethargy, weakness, difficulty moving, trembling and clinical signs of Cushing's syndrome (polyuria, polydipsia, alopecia and abdominal distension). After confirmation of the diagnosis of Cushing's disease and 2\u2009days after starting trilostane treatment (0.27 mg\/kg every 12 hours), the dog presented to our hospital with reluctance to rise. In the computed tomography scan, decreased bone density in cervical and thoracic vertebrae, ribs scapular bones and multiple rib fractures were detected. Despite 8 days of hospitalisation, reluctance to rise and walk persisted. Given the unfavourable progression of the diseases, the owner opted for euthanasia. Post mortem evaluation confirmed a cortical carcinoma of the left adrenal gland and thin, irregular spicules and trabeculae of compact bone and reduced thickness of the cortex of the ribs.<\/jats:p>","DOI":"10.1111\/jsap.13848","type":"journal-article","created":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T01:58:56Z","timestamp":1742176736000},"page":"514-520","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multiple pathological bone fractures in a dog with adrenal\u2010dependent Cushing's syndrome"],"prefix":"10.1111","volume":"66","author":[{"given":"C.","family":"Meli\u00e1n","sequence":"first","affiliation":[{"name":"Department of Animal Pathology, Faculty of Veterinary Medicine University of Las Palmas de Gran Canaria  Las Palmas Spain"},{"name":"Faculty of Veterinary Medicine, Veterinary Teaching Hospital University of Las Palmas de Gran Canaria  Las Palmas Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"P\u00e9rez\u2010L\u00f3pez","sequence":"additional","affiliation":[{"name":"Institute of Biomedical and Health Research (IUIBS) University of Las Palmas de Gran Canaria (ULPGC)  Las Palmas Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Encinoso","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Veterinary Teaching Hospital University of Las Palmas de Gran Canaria  Las Palmas Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Su\u00e1rez\u2010Cabrera","sequence":"additional","affiliation":[{"name":"Department of Morphology, Faculty of Veterinary Medicine University of Las Palmas de Gran Canaria  Las Palmas Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Quesada\u2010Canales","sequence":"additional","affiliation":[{"name":"Department of Morphology, Faculty of Veterinary Medicine University of Las Palmas de Gran Canaria  Las Palmas Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. R.","family":"Jaber","sequence":"additional","affiliation":[{"name":"Department of Morphology, Faculty of Veterinary Medicine University of Las Palmas de Gran Canaria  Las Palmas Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,3,16]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_6_2_1","DOI":"10.1111\/jvim.12192"},{"doi-asserted-by":"publisher","key":"e_1_2_6_3_1","DOI":"10.1007\/s11657-015-0244-1"},{"doi-asserted-by":"publisher","key":"e_1_2_6_4_1","DOI":"10.3389\/fendo.2019.00766"},{"doi-asserted-by":"publisher","key":"e_1_2_6_5_1","DOI":"10.1186\/s12891-023-06253-9"},{"doi-asserted-by":"publisher","key":"e_1_2_6_6_1","DOI":"10.1111\/jvim.12007"},{"doi-asserted-by":"publisher","key":"e_1_2_6_7_1","DOI":"10.1111\/jvim.16143"},{"doi-asserted-by":"publisher","key":"e_1_2_6_8_1","DOI":"10.1111\/j.1365-2885.2010.01174.x"},{"doi-asserted-by":"publisher","key":"e_1_2_6_9_1","DOI":"10.1210\/endrev\/bnab028"},{"doi-asserted-by":"publisher","key":"e_1_2_6_10_1","DOI":"10.2460\/javma.238.11.1441"},{"doi-asserted-by":"publisher","key":"e_1_2_6_11_1","DOI":"10.1007\/s12020-023-03318-6"},{"doi-asserted-by":"publisher","key":"e_1_2_6_12_1","DOI":"10.1002\/vetr.1630"},{"doi-asserted-by":"publisher","key":"e_1_2_6_13_1","DOI":"10.1159\/000314298"},{"doi-asserted-by":"publisher","key":"e_1_2_6_14_1","DOI":"10.1530\/eje.1.02067"},{"doi-asserted-by":"publisher","key":"e_1_2_6_15_1","DOI":"10.4142\/jvs.2015.16.4.531"},{"doi-asserted-by":"publisher","key":"e_1_2_6_16_1","DOI":"10.11005\/jbm.2014.21.4.277"},{"doi-asserted-by":"publisher","key":"e_1_2_6_17_1","DOI":"10.3389\/fvets.2020.00311"},{"key":"e_1_2_6_18_1","doi-asserted-by":"crossref","DOI":"10.1177\/20420188211030160","article-title":"A case of adrenal Cushing's syndrome and primary hyperparathyroidism due to an atypical parathyroid adenoma","volume":"31","author":"Newman C.","year":"2021","journal-title":"Therapeutic Advances in Endocrinology and Metabolism"},{"doi-asserted-by":"publisher","key":"e_1_2_6_19_1","DOI":"10.1177\/030098588802500402"},{"doi-asserted-by":"publisher","key":"e_1_2_6_20_1","DOI":"10.1111\/j.1748-5827.2005.tb00282.x"},{"key":"e_1_2_6_21_1","first-page":"4169","volume-title":"Textbook of veterinary internal medicine","author":"Skelly B.J.","year":"2017"},{"doi-asserted-by":"publisher","key":"e_1_2_6_22_1","DOI":"10.1007\/s40618-020-01269-7"},{"doi-asserted-by":"publisher","key":"e_1_2_6_23_1","DOI":"10.1111\/j.1748-5827.2005.tb00283.x"},{"doi-asserted-by":"publisher","key":"e_1_2_6_24_1","DOI":"10.1111\/cen.12189"},{"doi-asserted-by":"publisher","key":"e_1_2_6_25_1","DOI":"10.1007\/s00198-013-2520-5"},{"doi-asserted-by":"publisher","key":"e_1_2_6_26_1","DOI":"10.1016\/j.mpdhp.2012.03.006"}],"container-title":["Journal of Small Animal Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jsap.13848","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T11:07:49Z","timestamp":1751627269000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jsap.13848"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,16]]},"references-count":25,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1111\/jsap.13848"],"URL":"https:\/\/doi.org\/10.1111\/jsap.13848","archive":["Portico"],"relation":{},"ISSN":["0022-4510","1748-5827"],"issn-type":[{"type":"print","value":"0022-4510"},{"type":"electronic","value":"1748-5827"}],"subject":[],"published":{"date-parts":[[2025,3,16]]},"assertion":[{"value":"2024-04-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}