{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T01:10:21Z","timestamp":1788311421055,"version":"build-2803163510"},"reference-count":27,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T00:00:00Z","timestamp":1742169600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100018065","name":"EveryCat Health Foundation","doi-asserted-by":"publisher","award":["W21\u2010006"],"award-info":[{"award-number":["W21\u2010006"]}],"id":[{"id":"10.13039\/100018065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Small Animal Practice"],"published-print":{"date-parts":[[2025,7]]},"abstract":"\n Objectives<\/jats:title>\n This study aimed to: (1) characterise the pharmacokinetics of GS\u2010441524 following intravenous (iv) administration of 15\u2009mg\/kg remdesivir (RDV) in client\u2010owned cats with feline infectious peritonitis (FIP); (2) document plasma protein binding of GS\u2010441524 in cats; (3) determine whether trough GS\u2010441524 plasma concentrations predict \u2018simple remission\u2019 or survival to 18\u2009months; (4) measure GS\u2010441524 concentration in effusions relative to plasma; and (5) qualitatively assess excretion of GS\u2010441524 in urine.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods<\/jats:title>\n Six cats with FIP were administered 15\u2009mg\/kg iv RDV. Serial plasma GS\u2010441524 concentrations were measured using high\u2010performance liquid chromatography (HPLC). Twenty\u2010two cats with FIP had trough plasma concentrations monitored over a 12\u2010week treatment period. Simultaneous effusion and plasma GS\u2010441524 concentrations were compared, and urine was assessed for GS\u2010441524 excretion.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The mean peak plasma concentration of GS\u2010441524 (\n C<\/jats:italic>\n max<\/jats:sub>\n ) after a single 15\u2009mg\/kg iv dose of RDV was 2632\u2009ng\/mL (SD 862); time to reach\n C<\/jats:italic>\n max<\/jats:sub>\n (\n T<\/jats:italic>\n max<\/jats:sub>\n ) was 1\u2009hour (SD 0); and elimination half\u2010life (\n t<\/jats:italic>\n 1\/2<\/jats:sub>\n ) was 5.14\u2009hours (SD 0.81). GS\u2010441524 was present in effusions (\n n<\/jats:italic>\n \u2009=\u20093 cats) and eliminated in urine following treatment (\n n<\/jats:italic>\n \u2009=\u20096 cats). Assessment of the predictive relationship between median GS\n TC<\/jats:sub>\n and achieving \u2018simple remission\u2019 failed to demonstrate a significant correlation.\n <\/jats:p>\n <\/jats:sec>\n \n Clinical Significance<\/jats:title>\n This study supports the use of RDV and GS\u2010441524 for FIP treatment and suggests that population pharmacokinetic modelling is required to better explore the utility of therapeutic drug monitoring of GS\u2010441524.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jsap.13849","type":"journal-article","created":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T00:18:51Z","timestamp":1742257131000},"page":"495-506","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Pharmacokinetics of\n GS<\/scp>\n \u2010441524 following intravenous remdesivir in six cats and results of therapeutic drug monitoring during treatment of feline infectious peritonitis: 22 cases (2021\u20132024)"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8683-5014","authenticated-orcid":false,"given":"S. J.","family":"Coggins","sequence":"first","affiliation":[{"name":"Faculty of Science, Sydney School of Veterinary Science The University of Sydney Sydney New South Wales Australia"},{"name":"Centre for Veterinary Education The University of Sydney Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Govendir","sequence":"additional","affiliation":[{"name":"Faculty of Science, Sydney School of Veterinary Science The University of Sydney Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. M.","family":"Norris","sequence":"additional","affiliation":[{"name":"Faculty of Science, Sydney School of Veterinary Science The University of Sydney Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Malik","sequence":"additional","affiliation":[{"name":"Centre for Veterinary Education The University of Sydney Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. J.","family":"Hall","sequence":"additional","affiliation":[{"name":"Faculty of Science, Sydney School of Veterinary Science The University of Sydney Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. F.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Faculty of Science, Sydney School of Veterinary Science The University of Sydney Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Kimble","sequence":"additional","affiliation":[{"name":"Faculty of Science, Sydney School of Veterinary Science The University of Sydney Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,17]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-022-02292-6"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.16954"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkaa152"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/cts.13194"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.16803"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/01652176.2024.2305731"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/v14112429"},{"key":"e_1_2_10_9_1","unstructured":"EMAHUD. (2020)European Medicines Agency Human Medicines Division. Summary on compassionate use. Remdesivir Gilead. Product No. EMEA\/H\/K\/5622\/CU. 03 April 2020."},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.16804"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/cts.12840"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani11082257"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/01652176.2023.2246553"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0247546"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.0c01929"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X15606957"},{"key":"e_1_2_10_17_1","unstructured":"MUC. (2023)Minnesota Urolith Center College of Veterinary Medicine \u201cMysterious New Stone Type in Cats\u201d [Online].https:\/\/vetmed.umn.edu\/urolith\u2010center\/image\u2010of\u2010month\/mysterious\u2010new\u2010stone\u2010type\u2010cats#:~:text=Observing%20urinary%20signs%20in%20cats consumption%20to%20minimize%20stone%20formation. 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