{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T12:19:29Z","timestamp":1790252369552,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,4,18]],"date-time":"2025-04-18T00:00:00Z","timestamp":1744934400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,4,18]],"date-time":"2025-04-18T00:00:00Z","timestamp":1744934400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Small Animal Practice"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Feline infectious peritonitis can be treated with antiviral agents, such as remdesivir and GS\u2010441524. Standard treatment duration is 12\u2009weeks, but no criteria have been established for individualising the timing of treatment cessation based on specific case characteristics. This study aimed to investigate whether treatment cessation for feline infectious peritonitis could be determined using acute\u2010phase proteins and albumin\/globulin ratio and to evaluate whether treatment duration, following high\u2010dose induction, could be safely shortened.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Forty\u2010six cats with feline infectious peritonitis, excluding those with only ocular or neurological signs, were treated with a high initial dose (&gt;20\u2009mg\/kg\/day) of either injectable remdesivir or oral GS\u2010441524. Surviving cats continued on a maintenance dose tailored to their clinical signs after initial improvements. Clinical signs, acute\u2010phase protein levels, and albumin\/globulin ratios were regularly monitored to assess when to end treatment. Cases where treatment was concluded in less than 12\u2009weeks received supplementary mefloquine therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among the 46 included cats, 42 (91.3%) achieved long\u2010term survival, with 28 (66.7%) meeting the criteria for treatment cessation [median treatment duration, 57\u2009days (range, 45 to 74\u2009days)]. No recurrence was observed in any of the 42 cats, either during the treatment or within the 3\u2010month follow\u2010up period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Significance<\/jats:title>\n                    <jats:p>In some cats with feline infectious peritonitis a high\u2010dose induction protocol, using acute\u2010phase proteins and the albumin\/globulin ratio for treatment cessation, enabled a shorter treatment period than the conventional 12\u2009weeks, without observed recurrence. The criteria used in this study appear adequate for determining appropriate times for feline infectious peritonitis treatment cessation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jsap.13869","type":"journal-article","created":{"date-parts":[[2025,4,18]],"date-time":"2025-04-18T23:12:46Z","timestamp":1745017966000},"page":"617-626","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["High\u2010dose induction therapy and treatment termination criteria for feline infectious peritonitis with remdesivir,\n                    <scp>GS<\/scp>\n                    \u2010441524 and adjunctive mefloquine: 46 cases (2023)"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-8781-6093","authenticated-orcid":false,"given":"T.","family":"Kamiyoshi","sequence":"first","affiliation":[{"name":"Kobe Animal Clinic  Hyogo 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