{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T13:51:25Z","timestamp":1762523485343,"version":"build-2065373602"},"reference-count":29,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T00:00:00Z","timestamp":1750982400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Small Animal Practice"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Angiostrongylus vasorum (AV) is a metastrongylid parasite that has been associated with pulmonary hypertension (PH) in dogs. The objectives of the study were to describe the clinical presentation of dogs with AV and PH, document changes in tricuspid regurgitation maximum pressure gradient (TR Max PG) in subsequent months and years, record the survival to discharge and report the long\u2010term survival of these dogs and factors associated with mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Data from client\u2010owned dogs presenting to a teaching hospital between January 2007 and October 2023 with AV and PH were reviewed retrospectively. Signalment, presenting signs and echocardiographic reports were collected, and their survival to discharge noted. Date of death and loss of follow\u2010up were recorded. Univariable analysis was used to assess the association of different factors on long\u2010term survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty\u2010eight cases were identified with concurrent PH and AV, commonly presented in respiratory distress. Tricuspid regurgitation, as measured by TR Max PG on echocardiography, resolved in 9 of 28 (32.1%) cases. Survival to discharge was favourable at 92.9% (26\/28). The median duration of follow\u2010up was 196\u2009days. Survival time was documented, with 6 of 11 (54.5%) known dogs still alive at 2\u2009years post discharge. Treatment with sildenafil (Viagra; Pfizer) was associated with longer survival time and increased age was associated with a shorter survival time. The presence of right\u2010sided congestive heart failure was not associated with a shorter survival time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Significance<\/jats:title>\n                    <jats:p>Dogs with AV infestation and PH can live for prolonged periods (&gt;2\u2009years).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jsap.13893","type":"journal-article","created":{"date-parts":[[2025,6,28]],"date-time":"2025-06-28T02:19:47Z","timestamp":1751077187000},"page":"797-807","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The long\u2010term outcome and changes in tricuspid regurgitation pressure gradient in dogs diagnosed with pulmonary hypertension and\n                    <i>Angiostrongylus vasorum<\/i>\n                    infestation"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-6037-3933","authenticated-orcid":false,"given":"R.","family":"Turner","sequence":"first","affiliation":[{"name":"Department of Clinical Science and Services The Royal Veterinary College, University of London  Hatfield UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Connolly","sequence":"additional","affiliation":[{"name":"Department of Clinical Science and Services The Royal Veterinary College, University of London  Hatfield UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Brodbelt","sequence":"additional","affiliation":[{"name":"Department of Pathobiology and Population Sciences Royal Veterinary College  Hatfield UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Cortellini","sequence":"additional","affiliation":[{"name":"Department of Clinical Science and Services The Royal Veterinary College, University of London  Hatfield UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.prevetmed.2010.01.007","article-title":"Disease surveillance and referral bias in the veterinary medical database","volume":"94","author":"Bartlett P.C.","year":"2010","journal-title":"Preventive Veterinary Medicine"},{"key":"e_1_2_9_3_1","doi-asserted-by":"crossref","DOI":"10.1136\/vr.102186","article-title":"Spatial, demographic and clinical patterns of Angiostrongylus vasorum infection in the dog population of southern England","volume":"175","author":"Blehaut T.R.W.","year":"2014","journal-title":"Veterinary Record"},{"key":"e_1_2_9_4_1","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1136\/vr.135.19.447","article-title":"Canine angiostrongylosis: a review","volume":"135","author":"Bolt G.","year":"1994","journal-title":"Vet Rec"},{"key":"e_1_2_9_5_1","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1111\/jsap.12309","article-title":"Retrospective evaluation of moderate\u2010to\u2010severe pulmonary hypertension in dogs naturally infected with Angiostrongylus vasorum","volume":"56","author":"Borgeat K.","year":"2015","journal-title":"Journal of Small Animal Practice"},{"key":"e_1_2_9_6_1","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1111\/j.1748-5827.2004.tb00261.x","article-title":"Angiostrongylus vasorum infection in 23 dogs (1999\u20132002)","volume":"45","author":"Chapman P.S.","year":"2004","journal-title":"Journal of Small Animal Practice"},{"key":"e_1_2_9_7_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13071-016-1440-6","article-title":"Angiostrongylus vasorum in the eye: new case reports and a review of the literature","volume":"9","author":"Colella V.","year":"2016","journal-title":"Parasites & Vectors"},{"key":"e_1_2_9_8_1","first-page":"479","volume-title":"Veterinary epidemiologic research","author":"Dohoo I.R.","year":"2010"},{"key":"e_1_2_9_9_1","doi-asserted-by":"crossref","DOI":"10.1186\/s13567-014-0092-9","article-title":"Recent advances in the epidemiology, clinical and diagnostic features, and control of canine cardio\u2010pulmonary angiostrongylosis","volume":"45","author":"Elsheikha H.M.","year":"2014","journal-title":"Veterinary Research"},{"key":"e_1_2_9_10_1","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/j.1748-5827.2004.tb00226.x","article-title":"Reversible pulmonary hypertension presenting simultaneously with an atrial septal defect and angiostrongylosis in a dog","volume":"45","author":"Est\u00e8ves I.","year":"2004","journal-title":"Journal of Small Animal Practice"},{"key":"e_1_2_9_11_1","unstructured":"Glaus T.M.(2013)Pulmonary Hypertension andAngiostrongylus vasorum. 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