{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T06:09:18Z","timestamp":1765260558876,"version":"3.46.0"},"reference-count":44,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T00:00:00Z","timestamp":1750982400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Small Animal Practice"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Ferret systemic coronavirus\u2010associated disease is usually fatal in ferrets, and no specific treatments have been available to date. This disease shares similarities with feline infectious peritonitis, which has been successfully treated with antivirals in recent years. This report describes the effects of GS\u2010441524 in ferrets with naturally acquired ferret systemic coronavirus\u2010associated disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      Seven ferrets with ferret systemic coronavirus\u2010associated disease confirmed by immunohistochemistry on biopsy samples were treated with subcutaneous GS\u2010441524. Clinical signs and blood analysis including protein electrophoresis were periodically evaluated. Comorbidities and adverse effects during treatment were also recorded.\n                      <jats:italic>Post\u2010mortem<\/jats:italic>\n                      examination with histopathological evaluation was conducted on the deceased ferrets.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Clinical signs included respiratory, gastrointestinal, ocular and neurological disturbances, weight loss, lethargy and organomegaly. Initial hypergammaglobulinaemia and low albumin\u2010to\u2010globulin ratio were present in all ferrets. The dose range was 2 to 15\u2009mg\/kg\/sc SID, two or three times per week. Total treatment duration ranged from 24 to 103\u2009weeks. The clinical condition of all ferrets rapidly improved with increasing body weight after treatment initiation. Haematocrit, albumin and thrombocyte count normalised during the course of antiviral therapy, and plasmatic gamma globulin concentrations returned to normal in six of the seven ferrets. Survival time from the initiation of therapy ranged from 36 to 175\u2009weeks. Three ferrets died; no pyogranulomatous inflammatory lesions compatible with ferret systemic coronavirus\u2010associated disease were noted, and immunohistochemistry for coronavirus antigens was negative in all three.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Significance<\/jats:title>\n                    <jats:p>This study suggests injectable GS\u2010441524 could be an effective treatment to improve the clinical status, haematological parameters and survival times of ferrets affected with ferret systemic coronavirus\u2010associated disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jsap.13906","type":"journal-article","created":{"date-parts":[[2025,6,28]],"date-time":"2025-06-28T02:20:16Z","timestamp":1751077216000},"page":"877-885","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Treatment with subcutaneous\n                    <scp>GS<\/scp>\n                    \u2010441524 in ferrets affected by ferret systemic coronavirus\u2010associated disease: seven cases (2021\u20102024)"],"prefix":"10.1111","volume":"66","author":[{"given":"E.","family":"Camba Caride","sequence":"first","affiliation":[{"name":"Cl\u00ednica Veterinaria Quetzal  Vigo Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Ardiaca Garc\u00eda","sequence":"additional","affiliation":[{"name":"Medivet 24H Los Sauces  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Bonveh\u00ed Nadeu","sequence":"additional","affiliation":[{"name":"Medivet 24H Los Sauces  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Basurco P\u00e9rez","sequence":"additional","affiliation":[{"name":"Centro M\u00e9dico Veterinario Maidagan  Getxo Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Capdevila Andr\u00e9s","sequence":"additional","affiliation":[{"name":"Ex\u00f2tics Veterin\u00e0ria  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Montesinos Barcel\u00f3","sequence":"additional","affiliation":[{"name":"Medivet 24H Los Sauces  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Juan\u2010Sall\u00e9s","sequence":"additional","affiliation":[{"name":"Noah\u2019s Path  Elche Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/v12111216"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.16954"},{"key":"e_1_2_6_4_1","first-page":"508","article-title":"Systemic coronaviral disease in 5 ferrets","volume":"65","author":"Autieri C.","year":"2015","journal-title":"Comparative Medicine"},{"volume-title":"Tratamiento antiviral con GS\u2010441524 en un hur\u00f3n dom\u00e9stico (Mustela putorius furo) con coronavirus sist\u00e9mico","year":"2021","author":"Camba E.","key":"e_1_2_6_5_1"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jepm.2016.10.010"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.16803"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-26760-4"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/vcp.13067"},{"key":"e_1_2_6_10_1","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/B978-0-323-48435-0.00004-6","volume-title":"Ferrets, rabbits, and rodents. 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