{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T05:58:32Z","timestamp":1774331912021,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T00:00:00Z","timestamp":1753833600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T00:00:00Z","timestamp":1753833600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Small Animal Practice"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    Canine degenerative myelopathy (DM) has been associated with mutations in the superoxide dismutase 1 gene (\n                    <jats:italic>SOD1<\/jats:italic>\n                    ). Although the\n                    <jats:italic>SOD1:c.118G&gt;A<\/jats:italic>\n                    mutation has been identified in Boston terriers and French bulldogs, no histological\u2010confirmed degenerative myelopathy has been reported in either breed. An 8\u2010year\u2010old male neutered Boston terrier\u2013French bulldog mixed breed dog was presented with T3 to L3 myelopathy. Magnetic resonance imaging (MRI) of the spinal cord and cerebrospinal fluid analysis were unremarkable. DNA testing revealed homozygosity for the\n                    <jats:italic>SOD1:c.118G&gt;A<\/jats:italic>\n                    mutation. Despite supportive treatment, the dog continued to progress over 37\u2009months.\n                    <jats:italic>Post mortem<\/jats:italic>\n                    full spine MRI study found severe spinal cord and epaxial muscle atrophy. The diagnosis of DM was confirmed by histopathology and positive immunohistochemical staining with anti\u2010SOD1 antibodies. This case report documents the clinical and imaging progression of DM in a Boston terrier\u2013French bulldog mixed breed.\n                  <\/jats:p>","DOI":"10.1111\/jsap.70010","type":"journal-article","created":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T08:20:07Z","timestamp":1753863607000},"page":"86-91","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Diagnosis of degenerative myelopathy in a Boston terrier\u2013French bulldog mixed breed"],"prefix":"10.1111","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2736-6451","authenticated-orcid":false,"given":"A. M. K.","family":"Chan","sequence":"first","affiliation":[{"name":"Ontario Veterinary College University of Guelph  Guelph Ontario Canada"},{"name":"The VSCAN  Ottawa Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. R.","family":"Coates","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine University of Missouri  Columbia Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. C.","family":"Johnson","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine University of Missouri  Columbia Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. N.","family":"Snyman","sequence":"additional","affiliation":[{"name":"Animal Health Laboratory \u2013 Kemptville University of Guelph  Kemptville Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. W.","family":"Silversides","sequence":"additional","affiliation":[{"name":"Department of Veterinary Biomedicine, Faculty of Veterinary Medicine University of Montreal  Saint\u2010Hyacinthe Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,30]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.1973.162.12.1045"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0812297106"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.16829"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2007.tb01955.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2010.05.001"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1010651"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2019.00350"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1600084113"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.4142\/jvs.2005.6.4.341"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1354\/vp.46-2-241"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.1985.186.11.1213"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani11061702"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.21-0370"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2012.04.003"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2011.0760.x"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.12317"}],"container-title":["Journal of Small Animal Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jsap.70010","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jsap.70010","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jsap.70010","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T05:32:15Z","timestamp":1769146335000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jsap.70010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,30]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1111\/jsap.70010"],"URL":"https:\/\/doi.org\/10.1111\/jsap.70010","archive":["Portico"],"relation":{},"ISSN":["0022-4510","1748-5827"],"issn-type":[{"value":"0022-4510","type":"print"},{"value":"1748-5827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,30]]},"assertion":[{"value":"2023-12-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}