{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T20:02:42Z","timestamp":1791576162139,"version":"4.3.4"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100009449","name":"Petplan Charitable Trust","doi-asserted-by":"publisher","award":["S20\u2010931\u2010970"],"award-info":[{"award-number":["S20\u2010931\u2010970"]}],"id":[{"id":"10.13039\/100009449","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Small Animal Practice"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To assess chronic kidney disease in dogs after azotaemic acute kidney injury utilising serum creatinine, symmetric dimethylarginine and estimated glomerular filtration rate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Client\u2010owned dogs hospitalised for azotaemic acute kidney injury (T0) were evaluated at discharge (T1), 3\u2009months (T2) and 12 (T3) months with serum creatinine and symmetric dimethylarginine measured. In non\u2010azotaemic dogs (serum creatinine &lt;145\u2009\u03bcmol\/L) at T1 and T2, glomerular filtration rate was estimated by iohexol clearance. Acute kidney injury grade and chronic kidney disease stage were determined according to International Renal Interest Society guidelines. Non\u2010azotaemic dogs were considered to have kidney dysfunction if glomerular filtration rate was reduced \u226520% below the mean of the body weight category.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fifteen dogs with azotaemic acute kidney injury were recruited. At T0 peak, acute kidney injury grade was III (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20094), IV (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20098) and V (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20093). At T1, 10\/15 dogs remained azotaemic. At T2, 3\/15 dogs remained azotaemic; this persisted in 2\/3 dogs at T3. One dog was euthanised prior to T3 due to progression of azotaemia (stage 4). Based on glomerular filtration rate assessment, 4\/12 and 5\/12 non\u2010azotaemic dogs had evidence of kidney dysfunction at T2 and T3, respectively. Ten out of 15 dogs were classified as International Renal Interest Society chronic kidney disease stage 1 and 4\/15 dogs were stage 2 and 1\/15 dog that did not survive to T3 was stage 4.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Significance<\/jats:title>\n                    <jats:p>Persistent azotaemia occurs infrequently in dogs surviving beyond 3\u2009months after acute kidney injury. Estimated glomerular filtration rate may identify continued kidney dysfunction in non\u2010azotaemic dogs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jsap.70046","type":"journal-article","created":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T07:49:28Z","timestamp":1767080968000},"page":"254-263","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Preliminary study investigating the role of estimated glomerular filtration rate, proteinuria and hypertension to inform on chronic kidney disease after acute kidney injury"],"prefix":"10.1111","volume":"67","author":[{"given":"L. P.","family":"Cole","sequence":"first","affiliation":[{"name":"Department of Clinical Science and Services Royal Veterinary College  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6005-1975","authenticated-orcid":false,"given":"L.","family":"Pelligand","sequence":"additional","affiliation":[{"name":"Department of Clinical Science and Services Royal Veterinary College  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Jepson","sequence":"additional","affiliation":[{"name":"Department of Clinical Science and Services Royal Veterinary College  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5770-7950","authenticated-orcid":false,"given":"K.","family":"Humm","sequence":"additional","affiliation":[{"name":"Department of Clinical Science and Services Royal Veterinary College  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.15331"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.16435"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2007.0035.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11259-017-9694-9"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13028-019-0452-6"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2017.2"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsap.12150"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.15839"},{"key":"e_1_2_6_10_1","unstructured":"Cowgill L.(2016)IRIS Guideline Recommendations for Grading of AKI in dogs and cats. 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