{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T05:07:26Z","timestamp":1780636046271,"version":"3.54.1"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,1,4]],"date-time":"2026-01-04T00:00:00Z","timestamp":1767484800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,4]],"date-time":"2026-01-04T00:00:00Z","timestamp":1767484800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Small Animal Practice"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The primary aim of this study was to evaluate the sedative effects of injectable acepromazine 2\u2009mg\/mL when administered to dogs via the oral transmucosal route. The secondary objective was to assess the cardiovascular and haemodynamic effects of oral transmucosal acepromazine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>A single centre, prospective, randomised, blinded, controlled clinical trial, including a total of 28 client\u2010owned adult healthy dogs (ASA I and II), undergoing elective surgical procedures. Patients were randomised into either a treatment group (A) receiving oral transmucosal acepromazine 0.05\u2009mg\/kg or a control group (C) receiving an equivalent oral transmucosal volume of water. Baseline values of sedation score, heart rate and non\u2010invasive blood pressure were obtained prior to dose administration and repeated 1\u2009hour later.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Sedation scores in group A were significantly higher after treatment compared to baseline and were significantly higher than group C at the same time point. Heart rate and non\u2010invasive blood pressure values significantly decreased following oral transmucosal acepromazine administration in group A and were significantly lower than group C at the same time point.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Significance<\/jats:title>\n                    <jats:p>Oral transmucosal acepromazine significantly increases sedation scores and decreases heart rate and non\u2010invasive blood pressure 1\u2009hour following administration. These findings support the administration of oral transmucosal acepromazine for pre\u2010hospital sedation in healthy dogs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jsap.70082","type":"journal-article","created":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T00:18:14Z","timestamp":1767572294000},"page":"455-459","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Oral transmucosal administration of acepromazine to healthy dogs leads to increased sedation scores in a hospital setting"],"prefix":"10.1111","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-8597-1146","authenticated-orcid":false,"given":"M.","family":"Rollet","sequence":"first","affiliation":[{"name":"Department of Anaesthesia Southern Counties Veterinary Specialists  Ringwood UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4302-3152","authenticated-orcid":false,"given":"D.","family":"Flaherty","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia Southern Counties Veterinary Specialists  Ringwood UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Bell","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia Southern Counties Veterinary Specialists  Ringwood UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Karas","sequence":"additional","affiliation":[{"name":"Life4s Consulting and Care L.L.C.  Franklin Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3702-2145","authenticated-orcid":false,"given":"A.","family":"Auckburally","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia Southern Counties Veterinary Specialists  Ringwood UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,4]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.23.02.0067"},{"key":"e_1_2_6_3_1","volume-title":"Chill protocol to manage aggressive & fearful dogs","author":"Costa R.S.","year":"2019"},{"key":"e_1_2_6_4_1","first-page":"75","article-title":"Determination of blood pressure by indirect methods in dogs given acetylpromazine maleate","volume":"71","author":"Coulter D.B.","year":"1981","journal-title":"Cornell Veterinarian"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781119830306.ch22"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2008.05.006"},{"key":"e_1_2_6_7_1","unstructured":"Drugbank. 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