{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T10:18:54Z","timestamp":1780913934111,"version":"3.54.1"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T00:00:00Z","timestamp":1773532800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T00:00:00Z","timestamp":1773532800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Small Animal Practice"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To compare the prevalence and severity of polyuria and polydipsia in dogs receiving once\u2010daily or divided\u2010daily oral prednisolone regimens.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>In a randomised, crossover trial, 12 client\u2010owned dogs with diseases requiring oral prednisolone were treated with a daily dose \u22651.5\u2009mg\/kg, administered once\u2010daily or divided\u2010daily. The initial dosing regimen was administered for 14\u2009days and then switched to the alternative regimen for an additional 14\u2009days. Daily water intake, urine specific gravity and urine osmolality were measured before treatment and on days 7, 14, 21 and 28.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The median daily dose of prednisolone administered to dogs was 1.7\u2009mg\/kg (range: 1.5 to 2.1\u2009mg\/kg). Nine and six dogs experienced polydipsia and diluted urine (likely polyuria), respectively, without difference between once\u2010daily and divided\u2010daily regimens. Dogs treated with a once\u2010daily regimen exhibited significantly lower water intake on day 14 compared to those treated with divided\u2010daily prednisolone. Median urine specific gravity and urine osmolality did not differ between once\u2010daily and divided\u2010daily prednisolone administration. An almost linear positive correlation was established between urine specific gravity and osmolality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Significance<\/jats:title>\n                    <jats:p>Once\u2010daily rather than divided\u2010daily dosing is a reasonable option in dogs treated with oral prednisolone to reduce excessive water intake in the clinical setting. Urine specific gravity and osmolality can be used interchangeably for the assessment of urine concentration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jsap.70101","type":"journal-article","created":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T05:11:05Z","timestamp":1773637865000},"page":"557-564","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of polydipsia and polyuria in dogs treated with once\u2010daily or divided twice\u2010daily oral prednisolone in 12 dogs"],"prefix":"10.1111","volume":"67","author":[{"given":"E.","family":"Kouklaki","sequence":"first","affiliation":[{"name":"Companion Animal Clinic, School of Veterinary Medicine, Faculty of Health Sciences Aristotle University of Thessaloniki  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Konstantinidis","sequence":"additional","affiliation":[{"name":"Companion Animal Clinic, School of Veterinary Medicine, Faculty of Health Sciences Aristotle University of Thessaloniki  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2862-7182","authenticated-orcid":false,"given":"E.","family":"Meletis","sequence":"additional","affiliation":[{"name":"Laboratory of Epidemiology, Biostatistics, Applied Artificial Intelligence, Faculty of Public and One Health University of Thessaly  Karditsa Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7051-1541","authenticated-orcid":false,"given":"P.","family":"Kostoulas","sequence":"additional","affiliation":[{"name":"Laboratory of Epidemiology, Biostatistics, Applied Artificial Intelligence, Faculty of Public and One Health University of Thessaly  Karditsa Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8308-3371","authenticated-orcid":false,"given":"M. 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