{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T18:16:00Z","timestamp":1783016160823,"version":"3.54.6"},"reference-count":26,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:00:00Z","timestamp":1772064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:00:00Z","timestamp":1772064000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100031829","name":"Ceva Sant\u00e9 Animale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100031829","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Small Animal Practice"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aimed to assess the effectiveness of a protocol involving the application of topical products (DOUXO\u00ae S3 SEB Shampoo and Mousse; Ceva Sant\u00e9 Animale) containing ophytrium for managing feline keratinisation disorders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Nineteen client\u2010owned cats with a history of keratinisation disorders exhibited greasy or dry seborrhoea. Cats were treated with either a shampoo or mousse on day 0 (D0) and subsequently with the mousse every 48 to 72\u2009hours for 3\u2009weeks. Clinical signs were evaluated on D0, D7 and D21 using a modified Skin Seborrheic Index, which measured the percentage of body area affected, scaling, coat greasiness and secondary dermatological signs. Both veterinarians and owners provided subjective evaluations of overall skin condition and product efficacy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 17 cats that completed the study, SSI scores improved significantly by D7 and D21, with reductions of \u226550% in 82.4% of cats. By D21, the affected body surface had decreased by 92.9%, scaling by 70.5% and greasiness by 68.3%. Veterinarians rated the improvement as satisfactory, good or excellent in 100% of cases. The protocol was deemed effective and practical by 100% and 88.2% of owners, respectively, with 94.1% declaring an improved condition of their cats' skin and coat.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Significance<\/jats:title>\n                    <jats:p>The ophytrium\u2010containing mousse and shampoo protocol was well tolerated and effective in significantly reducing seborrhoea in cats with keratinisation disorders. High satisfaction levels were reported by both veterinarians and owners, highlighting the protocol's efficacy and practicality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jsap.70104","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T22:26:03Z","timestamp":1773008763000},"page":"619-626","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of safety and efficacy of an ophytrium and seboliance\u2010containing mousse with or without shampoo in cats with keratinisation disorders"],"prefix":"10.1111","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2310-9813","authenticated-orcid":false,"given":"C.","family":"Noli","sequence":"first","affiliation":[{"name":"Servizi Dermatologici Veterinari  Peveragno Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4950-4906","authenticated-orcid":false,"given":"H.","family":"Dropsy","sequence":"additional","affiliation":[{"name":"Department of Dermatology National Veterinary School of Alfort  Maisons\u2010Alfort France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7535-9067","authenticated-orcid":false,"given":"A.","family":"Cozar","sequence":"additional","affiliation":[{"name":"Ceva Sant\u00e9 Animale  Libourne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"De Jaeger","sequence":"additional","affiliation":[{"name":"Ceva Sant\u00e9 Animale  Libourne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Kesteman","sequence":"additional","affiliation":[{"name":"Ceva Sant\u00e9 Animale  Libourne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Beck","sequence":"additional","affiliation":[{"name":"Ceva Sant\u00e9 Animale  Libourne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Cristante","sequence":"additional","affiliation":[{"name":"Clinique V\u00e9t\u00e9rinaire du Vernet  Vernet France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Debraine","sequence":"additional","affiliation":[{"name":"Clinique V\u00e9t\u00e9rinaire Vetocare  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Leymarios","sequence":"additional","affiliation":[{"name":"Clinique V\u00e9t\u00e9rinaire Feli' Sant\u00e9  Saint Nazaire France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Puozzo\u2010Barichard","sequence":"additional","affiliation":[{"name":"Chatdoc Clinique  Bayonne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Gatellet","sequence":"additional","affiliation":[{"name":"Ceva Sant\u00e9 Animale  Libourne France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,26]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"crossref","DOI":"10.1186\/s12906-016-1237-3","article-title":"Chemical analysis of Punica granatum fruit peel and its in\u00a0vitro and in\u00a0vivo biological properties","volume":"16","author":"Barathikannan K.","year":"2016","journal-title":"BMC Complementary and Alternative Medicine"},{"key":"e_1_2_10_3_1","doi-asserted-by":"crossref","DOI":"10.1186\/s12906-017-1555-0","article-title":"Anti\u2010inflammatory potential of ellagic acid, gallic acid and punicalagin A&B isolated from Punica granatum","volume":"17","author":"BenSaad L.A.","year":"2017","journal-title":"BMC Complementary and Alternative Medicine"},{"key":"e_1_2_10_4_1","first-page":"1","article-title":"Utilisation d'un spot\u2010on \u00e0 base d'huiles essentielles pour le contr\u00f4le des \u00e9tats k\u00e9ratos\u00e9borrh\u00e9iques du chat: \u00e9tude ouverte","volume":"27","author":"Bensignor E.","year":"2007","journal-title":"Informations Dermatologiques V\u00e9t\u00e9rinaires"},{"key":"e_1_2_10_5_1","first-page":"49","article-title":"A multicentric randomised controlled single blinded study to evaluate the value of a new protocol with a shampoo and a foam to treat canine allergic dermatitis","volume":"48","author":"Bensignor E.","year":"2013","journal-title":"Veterinary Dermatology"},{"key":"e_1_2_10_6_1","doi-asserted-by":"crossref","DOI":"10.3402\/fnr.v59.27620","article-title":"Antibacterial activity of fresh pomegranate juice against clinical strains of Staphylococcus epidermidis","volume":"59","author":"Betanzos\u2010Cabrera G.","year":"2015","journal-title":"Food & Nutrition Research"},{"key":"e_1_2_10_7_1","first-page":"28","article-title":"Biology, diagnosis and treatment of Malassezia dermatitis in dogs and cats: clinical consensus guidelines of the World Association for Veterinary Dermatology","volume":"31","author":"Bond R.","year":"2020","journal-title":"Veterinary Dermatology"},{"key":"e_1_2_10_8_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.plefa.2020.102140","article-title":"A prospective, randomized, double\u2010blind, placebo\u2010controlled evaluation of the effects of an essential fatty acids supplement (Agepi\u00ae \u03c93) on clinical signs and fatty acid concentrations in dogs with poor quality coats","volume":"159","author":"Combarros D.","year":"2020","journal-title":"Prostaglandins, Leukotrienes, and Essential Fatty Acids"},{"key":"e_1_2_10_9_1","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.mmcr.2013.01.005","article-title":"Generalized dermatitis associated with Malassezia overgrowth in cats: a report of six cases in France","volume":"2","author":"Crosaz O.","year":"2013","journal-title":"Medical Mycology Case Reports"},{"key":"e_1_2_10_10_1","doi-asserted-by":"crossref","DOI":"10.1177\/1098612X241264718","article-title":"Performance of applications of ophytrium\u2010containing mousse with or without shampoo in cats with pruritic and irritated skin: a multicentre prospective field trial","volume":"26","author":"Dropsy H.","year":"2024","journal-title":"Journal of Feline Medicine and Surgery"},{"key":"e_1_2_10_11_1","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/vde.12282","article-title":"Sebaceous adenitis and mural folliculitis in a cat responsive to topical fatty acid supplementation","volume":"27","author":"Glos K.","year":"2016","journal-title":"Veterinary Dermatology"},{"key":"e_1_2_10_12_1","doi-asserted-by":"crossref","DOI":"10.1002\/vetr.2778","article-title":"Morbidity of insured Swedish cats between 2011 and 2016: comparing disease risk in domestic crosses and purebreds","volume":"192","author":"Hadar B.N.","year":"2023","journal-title":"Veterinary Record"},{"key":"e_1_2_10_13_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.tvjl.2024.106084","article-title":"Malassezia dermatitis in dogs and cats","volume":"304","author":"Hobi S.","year":"2024","journal-title":"Veterinary Journal"},{"key":"e_1_2_10_14_1","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1177\/1098612X15616433","article-title":"Morbidity pattern by age, sex and breed in insured cats in Japan (2008\u20132013)","volume":"18","author":"Inoue M.","year":"2016","journal-title":"Journal of Feline Medicine and Surgery"},{"key":"e_1_2_10_15_1","first-page":"104","volume-title":"SCIVAC Dermatology Congress Proceedings","author":"Kolasa E.","year":"2019"},{"key":"e_1_2_10_16_1","doi-asserted-by":"crossref","DOI":"10.3390\/vetsci10020095","article-title":"Performance and tolerance of a protocol for idiopathic chronic greasy seborrhea in dogs using a shampoo and mousse containing plant extracts","volume":"10","author":"Kondratjeva J.","year":"2023","journal-title":"Veterinary Sciences"},{"key":"e_1_2_10_17_1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18010141","article-title":"Multiple activities of Punica granatum Linne against acne vulgaris","volume":"18","author":"Lee C.J.","year":"2017","journal-title":"International Journal of Molecular Sciences"},{"key":"e_1_2_10_18_1","doi-asserted-by":"crossref","DOI":"10.3390\/vetsci11060229","article-title":"Effects of a protocol combining a non\u2010irritating shampoo and an adelmidrol\u2010based adsorbent mousse on seborrhea secondary to canine atopic dermatitis","volume":"11","author":"Noli C.","year":"2024","journal-title":"Veterinary Sciences"},{"key":"e_1_2_10_19_1","first-page":"442","volume-title":"BSAVA Congress Proceedings","author":"Ollivier E.","year":"2019"},{"key":"e_1_2_10_20_1","first-page":"442","volume-title":"BSAVA Congress Proceedings","author":"Ollivier E.","year":"2019"},{"key":"e_1_2_10_21_1","doi-asserted-by":"crossref","first-page":"250","DOI":"10.2174\/1389201019666180515104800","article-title":"Antifungal activity and GC\u2013MS analysis of Punica granatum peel extracts against fluconazole\u2010resistant Candida spp","volume":"19","author":"Paul S.","year":"2018","journal-title":"Current Pharmaceutical Biotechnology"},{"key":"e_1_2_10_22_1","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1177\/1098612X221128760","article-title":"2022 AAFP\/ISFM cat friendly veterinary interaction guidelines","volume":"24","author":"Rodan I.","year":"2022","journal-title":"Journal of Feline Medicine and Surgery"},{"key":"e_1_2_10_23_1","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1053\/j.ctsap.2006.05.003","article-title":"Practical applications of topical therapy for allergic, infectious and seborrheic disorders","volume":"21","author":"Rosenkrantz W.","year":"2006","journal-title":"Clinical Techniques in Small Animal Practice"},{"key":"e_1_2_10_24_1","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1177\/1098612X12468922","article-title":"Feline dermatology at Cornell University: 1407 cases (1988\u20132003)","volume":"15","author":"Scott D.W.","year":"2013","journal-title":"Journal of Feline Medicine and Surgery"},{"key":"e_1_2_10_25_1","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/S0195-5616(95)50129-9","article-title":"Exudative, crusting, and scaling dermatoses","volume":"25","author":"Sousa C.A.","year":"1995","journal-title":"The Veterinary Clinics of North America. Small Animal Practice"},{"key":"e_1_2_10_26_1","first-page":"457","article-title":"Topical retinoic acid in the treatment of feline tail gland hyperplasia (stud tail)","volume":"52","author":"Ural K.","year":"2008","journal-title":"Bulletin of the Veterinary Institute in Pulawy"},{"key":"e_1_2_10_27_1","doi-asserted-by":"crossref","DOI":"10.1136\/vr.100643","article-title":"Comparison of two shampoos as sole treatment for canine bacterial overgrowth syndrome","volume":"170","author":"Viaud S.","year":"2012","journal-title":"Veterinary Record"}],"container-title":["Journal of Small Animal Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jsap.70104","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jsap.70104","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jsap.70104","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T17:18:32Z","timestamp":1783012712000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jsap.70104"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,26]]},"references-count":26,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1111\/jsap.70104"],"URL":"https:\/\/doi.org\/10.1111\/jsap.70104","archive":["Portico"],"relation":{},"ISSN":["0022-4510","1748-5827"],"issn-type":[{"value":"0022-4510","type":"print"},{"value":"1748-5827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,26]]},"assertion":[{"value":"2025-06-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}