{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T11:22:35Z","timestamp":1788434555525,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T00:00:00Z","timestamp":1784505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T00:00:00Z","timestamp":1784505600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Small Animal Practice"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To compare the effects of topical prilocaine and lidocaine, relative to topical 0.9% sodium chloride, on laryngeal reactivity in anaesthetised cats prior to endotracheal intubation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      In this prospective, randomised, controlled, double\u2010blind study, 24 healthy adult\u00a0cats were enrolled and allocated to topical prilocaine, topical lidocaine or topical 0.9% sodium chloride (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20098\/group) following anaesthesia with a standardised medetomidine\u2010propofol protocol. The calculated volume of each local anaesthetic corresponding to 2\u2009mg\/kg, prepared from 2% stock solutions, was diluted with 0.9% sodium chloride to a standardised final volume of 0.5\u2009mL and atomised onto the arytenoid and vocal fold regions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Relative to sodium chloride, prilocaine was associated with lower laryngeal reactivity at earlier time points (15 to 45\u2009seconds), whereas lidocaine showed a later onset (from 60\u2009seconds onward). Between 60 and 90\u2009seconds, both prilocaine and lidocaine resulted in lower reactivity scores than sodium chloride, and no difference was observed between prilocaine and lidocaine at any assessed time point. No clinically evident adverse events were recorded during clinical monitoring of SpO\n                      <jats:sub>2<\/jats:sub>\n                      , heart rate, respiratory pattern, mucous membrane colour and clinical signs such as local irritation, hypersalivation, vomiting, marked gagging, apnoea, desaturation, bradycardia or arrhythmia.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Significance<\/jats:title>\n                    <jats:p>Topical prilocaine and lidocaine reduced laryngeal reactivity compared with topical 0.9% sodium chloride under the conditions of this study. The observed reductions occurred within the assessed 15 to 60\u2009seconds interval; however, intubation conditions were not evaluated as comparative outcomes, and the clinical implications should therefore be interpreted in relation to laryngeal reactivity rather than direct measures of intubation performance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jsap.70179","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:36:00Z","timestamp":1784594160000},"page":"836-842","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Time\u2010dependent laryngeal desensitisation following topical lidocaine and prilocaine application in\u00a0cats: a randomised controlled study"],"prefix":"10.1111","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9798-8638","authenticated-orcid":false,"given":"A.","family":"G\u00f6lgeli Bedir","sequence":"first","affiliation":[{"name":"Department of Surgery, Faculty of Veterinary Medicine Ataturk University  Erzurum T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5890-8271","authenticated-orcid":false,"given":"L. E.","family":"Yanmaz","sequence":"additional","affiliation":[{"name":"Department of Surgery, Faculty of Veterinary Medicine Burdur Mehmet Akif Ersoy University  Burdur T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6104-8393","authenticated-orcid":false,"given":"Y.","family":"Ak\u00e7ora","sequence":"additional","affiliation":[{"name":"Department of Surgery, Faculty of Veterinary Medicine Ataturk University  Erzurum T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9402-5679","authenticated-orcid":false,"given":"\u00c7.","family":"\u00d6zkal\u0131p\u00e7\u0131","sequence":"additional","affiliation":[{"name":"Department of Surgery, Faculty of Veterinary Medicine Ataturk University  Erzurum T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4184-8879","authenticated-orcid":false,"given":"\u00d6. T.","family":"Orhun","sequence":"additional","affiliation":[{"name":"Department of Surgery, Faculty of Veterinary Medicine Necmettin Erbakan University  Konya T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3580-7782","authenticated-orcid":false,"given":"Y.","family":"Kocaman","sequence":"additional","affiliation":[{"name":"Department of Surgery, Faculty of Veterinary Medicine Yozgat Bozok University  Yozgat T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2620-897X","authenticated-orcid":false,"given":"S.","family":"Okur","sequence":"additional","affiliation":[{"name":"Department of Surgery, Faculty of Veterinary Medicine Ataturk University  Erzurum T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,20]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.2344\/0003\u20103006\u201059.2.90"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaa.2016.10.004"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aem229"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaa.2022.06.004"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X20917309"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.1988.192.09.1286"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781119830306.ch29"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0140\u20107783.2003.00536.x"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.113.051714"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X20967886"},{"key":"e_1_2_11_12_1","first-page":"742","volume-title":"Miller's anesthesia","author":"Lirk P.","year":"2025"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2000.216.1592"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.SGA.0000296253.78457.f4"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/0310057X8301100110"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X18781391"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/0310057X8501300205"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.79.6.614"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjae.2019.10.002"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsap.13825"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfms.2005.10.002"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/87.1.27"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aem327"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.15772"}],"container-title":["Journal of Small Animal Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jsap.70179","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jsap.70179","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jsap.70179","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T11:10:31Z","timestamp":1788433831000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jsap.70179"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,20]]},"references-count":23,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1111\/jsap.70179"],"URL":"https:\/\/doi.org\/10.1111\/jsap.70179","archive":["Portico"],"relation":{},"ISSN":["0022-4510","1748-5827"],"issn-type":[{"value":"0022-4510","type":"print"},{"value":"1748-5827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,20]]},"assertion":[{"value":"2026-02-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}