{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T10:44:01Z","timestamp":1785840241289,"version":"3.56.0"},"reference-count":32,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Small Animal Practice"],"abstract":"\n Objectives<\/jats:title>\n Pulmonary carcinoma in dogs is commonly managed with surgical resection; however, the role of adjuvant chemotherapy for grade II and III carcinomas remains unclear. This retrospective multicentre study investigated the outcomes in dogs treated with vinorelbine\u2010based adjuvant treatment (as monotherapy or combined chemotherapy) following surgical resection, compared to surgical resection alone.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods<\/jats:title>\n Fifty\u2010six dogs with histologically confirmed grade II and III pulmonary carcinoma were evaluated in this study. Thirty\u2010six dogs received vinorelbine\u2010based adjuvant treatment post\u2010surgery based on owner decision following consultation with a veterinary oncologist. Twenty dogs underwent surgical resection alone. The progression\u2010free survival and overall survival were assessed using Cox proportional hazards analysis.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The median progression\u2010free survival was longer in dogs treated with vinorelbine\u2010based adjuvant treatment (232\u2009days, 95% CI 137 to 385\u2009days) compared to dogs treated with surgical resection only (124\u2009days, 95% CI 36 to 220\u2009days) (HR 0.39, 95% CI 0.21 to 0.70,\n P<\/jats:italic>\n \u2009=\u2009.003). The median overall survival was longer in dogs treated with vinorelbine\u2010based adjuvant treatment (316\u2009days, 95% CI 180 to 457\u2009days) compared to dogs treated with surgical resection only (124\u2009days, 95% CI 43 to 256\u2009days) (HR 0.31, 95% CI 0.17 to 0.58,\n P<\/jats:italic>\n \u2009<\u2009.001). The use of vinorelbine\u2010based adjuvant treatment and tumour grade were independent predictors of progression\u2010free survival and survival (\n P<\/jats:italic>\n \u2009<\u2009.001).\n <\/jats:p>\n <\/jats:sec>\n \n Clinical Significance<\/jats:title>\n These findings suggest that vinorelbine\u2010based adjuvant treatment is associated with longer progression\u2010free survival and overall survival in dogs with grade II and III pulmonary carcinoma following surgical resection in this cohort. However, the variability in treatment protocols used in this study limits our ability to draw definitive conclusions regarding treatment efficacy.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jsap.70183","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T09:47:42Z","timestamp":1785836862000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Survival outcomes in dogs treated with vinorelbine\u2010based adjuvant treatment following surgical resection of grade\n II<\/scp>\n and\n III<\/scp>\n pulmonary carcinoma"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0607-8795","authenticated-orcid":false,"given":"N.","family":"Wong","sequence":"first","affiliation":[{"name":"Animal Referral Hospital Canberra Pialligo Australian Capital Territory Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4505-8447","authenticated-orcid":false,"given":"L.","family":"Brockley","sequence":"additional","affiliation":[{"name":"Advanced Vetcare Kensington Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Rajan","sequence":"additional","affiliation":[{"name":"Faculty of Science, Melbourne Veterinary School The University of Melbourne Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4661-8311","authenticated-orcid":false,"given":"J.","family":"Yu","sequence":"additional","affiliation":[{"name":"Animal Referral Hospital Canberra Pialligo Australian Capital Territory Australia"},{"name":"Department of Veterinary Clinical Sciences Jockey Club College of Veterinary Medicine and Life Sciences, City University of Hong Kong Kowloon Tong Hong Kong, 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