{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T06:31:50Z","timestamp":1786429910241,"version":"build-2736575974"},"reference-count":20,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Small Animal Practice"],"abstract":"<jats:p>We describe two cats with diabetes mellitus and Cushing's syndrome. Diabetes mellitus was initially managed with insulin glargine (Lantus; Sanofi\u2010Aventis, Paris, France), nutritional therapy and continuous glucose monitoring. Hypercortisolism was suspected based on severe hypertension (Case 1), and insulin resistance in combination with typical clinical features of Cushing's syndrome (Case 2). Endocrine testing revealed non\u2010suppressible cortisol concentrations on low\u2010dose\u2010dexamethasone suppression test, elevated endogenous adenocorticotrophic hormone (ACTH) concentration and pituitary enlargement on computed tomography. Cabergoline (Holiday\u00ae, Holliday\u2010Scott S.A., Buenos Aires, Argentina) was initiated at a dose of 10\u2009\u03bcg\/kg po every 48\u2009hours targeting both the pituitary tumour and hypercortisolism. In Case 2, the cabergoline dosage was gradually increased to a final dose of 10\u2009\u03bcg\/kg po every 12\u2009hours. Both cats achieved diabetic remission within 1 and 6\u2009months of treatment, respectively. Serial monitoring demonstrated a decrease in endogenous ACTH concentrations and a reduction in pituitary volume of 29% of baseline (Case 1) and of 52% of baseline (Case 2) after 8\u2009months of treatment. These findings suggest that cabergoline may be a potential medical treatment option in cats with pituitary\u2010dependent hypercortisolism.<\/jats:p>","DOI":"10.1111\/jsap.70185","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T06:23:30Z","timestamp":1786429410000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pituitary tumour shrinkage and diabetic remission in two cats with Cushing syndrome treated with cabergoline"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1912-2409","authenticated-orcid":false,"given":"S.","family":"Teyssandier","sequence":"first","affiliation":[{"name":"Veterinary Endocrinology Center, Centro de endocrinologia de alta complejidad  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Galac","sequence":"additional","affiliation":[{"name":"Faculteit Diergeneeskunde  Utrecht Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,10]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1111\/j.1748-5827.2011.01150.x","article-title":"Severe systemic hypertension in a cat with pituitary\u2010dependent hyperadrenocorticism","volume":"53","author":"Brown A.L.","year":"2012","journal-title":"The Journal of Small Animal Practice"},{"key":"e_1_2_5_3_1","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.rvsc.2007.08.009","article-title":"Cushing's disease in dogs: cabergoline treatment","volume":"85","author":"Castillo V.A.","year":"2008","journal-title":"Research in Veterinary Science"},{"key":"e_1_2_5_4_1","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.3390\/ani13121935","article-title":"Computed tomographic assessment of pituitary gland dimensions in domestic short\u2010haired cats","volume":"13","author":"Costanza 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