{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T08:44:40Z","timestamp":1792140280952,"version":"4.4.0"},"reference-count":38,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:00:00Z","timestamp":1792108800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:00:00Z","timestamp":1792108800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Small Animal Practice"],"abstract":"\n Objectives<\/jats:title>\n The aim of this study was to evaluate urinary liver\u2010type fatty acid\u2010binding protein levels in both obstructive and non\u2010obstructive feline lower urinary tract disease. In addition, urinary liver\u2010type fatty acid\u2010binding protein levels were investigated in cats experiencing short\u2010term (<36 hours) and long\u2010term (\u226536 hours) urethral obstruction.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods<\/jats:title>\n \n The study included 32 cats, classified into two main groups: cats with feline lower urinary tract disease (\n n<\/jats:italic>\n =\u200924) and healthy controls (\n n<\/jats:italic>\n =\u20098). The feline lower urinary tract disease group was subdivided into obstructive (\n n<\/jats:italic>\n =\u200916) and non\u2010obstructive (\n n<\/jats:italic>\n =\u20098) forms. The obstructive group was further divided based on urethral obstruction duration into short\u2010term (\n n<\/jats:italic>\n =\u20098) and long\u2010term (\n n<\/jats:italic>\n =\u20098) sub\u2010subgroups. Serum creatinine, blood urea nitrogen and potassium were measured in blood samples. Urinary liver\u2010type fatty acid\u2010binding protein and urinary creatinine concentrations were measured in urine supernatant samples. Urinary liver\u2010type fatty acid\u2010binding protein concentrations were indexed to urinary creatinine and expressed as the urinary liver\u2010type fatty acid\u2010binding protein\/creatinine ratio.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The mean urinary liver\u2010type fatty acid\u2010binding protein\/creatinine values of cats with obstructive feline lower urinary tract disease were statistically higher than those in cats with non\u2010obstructive feline lower urinary tract disease and healthy controls. The difference between the mean urinary liver\u2010type fatty acid\u2010binding protein\/creatinine values of cats with long\u2010term and short\u2010term obstruction was not statistically significant. In addition, moderately positive correlations were calculated between urinary liver\u2010type fatty acid\u2010binding protein\/creatinine and serum creatinine (\n r<\/jats:italic>\n = .646;\n P<\/jats:italic>\n < .001; 95% CI\u2009=\u20090.264 to 0.863) and between urinary liver\u2010type fatty acid\u2010binding protein\/creatinine and blood urea nitrogen (\n r<\/jats:italic>\n = .549;\n P<\/jats:italic>\n < .01; 95% CI\u2009=\u20090.081 to 0.791) in the study population.\n <\/jats:p>\n <\/jats:sec>\n \n Clinical Significance<\/jats:title>\n This study is the first to report urinary liver\u2010type fatty acid\u2010binding protein\/creatinine in cats with feline lower urinary tract disease. The findings suggest that urinary liver\u2010type fatty acid\u2010binding protein\/creatinine may serve as a potential biomarker for identifying post\u2010renal acute kidney injury in cats with obstructive feline lower urinary tract disease, particularly in long\u2010term obstructive cases.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jsap.70212","type":"journal-article","created":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T07:57:10Z","timestamp":1792137430000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Urinary liver\u2010type fatty acid\u2010binding protein in cats with lower urinary tract disease"],"prefix":"10.1111","author":[{"given":"N.","family":"Culha","sequence":"first","affiliation":[{"name":"Faculty of Veterinary Medicine, Department of Internal Medicine Ayd\u0131n Adnan Menderes University Ayd\u0131n Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Acar","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Department of Internal Medicine Afyon Kocatepe University Afyonkarahisar Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8399-7082","authenticated-orcid":false,"given":"B.","family":"Ulutas","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Department of Internal Medicine Ayd\u0131n Adnan Menderes University Ayd\u0131n Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0706-1856","authenticated-orcid":false,"given":"C.","family":"Dinler Ay","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Department of Internal Medicine Ayd\u0131n Adnan Menderes University Ayd\u0131n Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,16]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"2255","article-title":"Pathophysiology of urethral obstruction","volume":"26","author":"Bartges J.W.","year":"1996","journal-title":"Veterinary Clinics of North America: Small Animal Practice"},{"key":"e_1_2_9_3_1","article-title":"Biochemical, electrolytic, and cardiovascular evaluations in cats with urethral obstruction","volume":"14","author":"Canei D.H.","year":"2021","journal-title":"Veterinary World"},{"key":"e_1_2_9_4_1","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.tvjl.2024.106262","article-title":"Urinary cystatin B as a marker of acute kidney injury in cats","volume":"308","author":"Chen H.","year":"2024","journal-title":"The Veterinary Journal"},{"key":"e_1_2_9_5_1","doi-asserted-by":"crossref","first-page":"12647","DOI":"10.1111\/jsap.12150","article-title":"Biomarkers in the 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