{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:46:43Z","timestamp":1788482803907,"version":"build-2803163510"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,10,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Almost half of breast cancer survivors experience chronic sexual problems. Despite the negative effects of dyspareunia on physical and overall quality of life, sexual dysfunction remains underreported and undertreated in clinical practice. This is likely due to the paucity of evidence-based interventions to improve sexual functioning.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>The study aims to prospectively evaluate the acceptability, feasibility, and efficacy of a novel intervention (Olive Oil, Vaginal Exercise, and MoisturizeR [OVERcome]) to improve sexual problems following breast cancer treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcome Measures<\/jats:title>\n                    <jats:p>Dyspareunia, sexual functioning, quality of life, distress, and pelvic floor muscles (PFMs) functioning were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twenty-five women with dyspareunia were instructed to perform pelvic floor muscle (PFM) relaxation exercises twice\/day to prevent\/manage PFM overactivity, apply a polycarbophil-based vaginal moisturizer three times\/week to alleviate vaginal dryness, use olive oil as a lubricant during intercourse, and complete a weekly compliance diary. PFM relaxation training was administered by a physiotherapist at weeks 0 and 4, with follow-up at weeks 12 and 26. At each visit, women completed validated self-report questionnaires and the physiotherapist recorded objective measures of PFM functioning.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>OVERcome resulted in significant improvements in dyspareunia, sexual function, and quality of life over time (all P &amp;lt; 0.001). PFM relaxation training was reported to be effective (P \u2264 0.001). Maximum benefits were observed at week 12. Most women rated PFM relaxation exercises (92%), vaginal moisturizer (88%), and olive oil (73%) as helpful, indicating that the intervention was acceptable. Unexpectedly, six cases (11%) of vaginal stenosis were noted during initial screening.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This novel intervention is acceptable to patients with demonstrated efficacy in improving dyspareunia and sexual function following breast cancer. Delivery of the OVERcome intervention appears feasible in a clinical setting, providing a potential treatment for this important clinical issue. The unexpected number of observed cases of stenosis further highlights the underreporting of sexual problems in this population, deserving further exploration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jsm.12156","type":"journal-article","created":{"date-parts":[[2013,5,2]],"date-time":"2013-05-02T03:11:39Z","timestamp":1367464299000},"page":"2549-2558","source":"Crossref","is-referenced-by-count":64,"title":["The Acceptability, Feasibility, and Efficacy (Phase I\/II Study) of the OVERcome (Olive Oil, Vaginal Exercise, and MoisturizeR) Intervention to Improve Dyspareunia and Alleviate Sexual Problems in Women with Breast Cancer"],"prefix":"10.1093","volume":"10","author":[{"given":"Ilona","family":"Juraskova","sequence":"first","affiliation":[{"name":"Centre for Medical Psychology & Evidence-based Decision-making (CeMPED), The University of Sydney , Sydney, NSW , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherin","family":"Jarvis","sequence":"additional","affiliation":[{"name":"Department of Endo-Gynaecology, The Barbara Gross Research Unit, Royal Hospital for Women , Sydney, NSW , Australia"},{"name":"School of Women's and Children's Health, University of New South Wales , Sydney, NSW , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"Mok","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Prince of Wales Hospital , Sydney, NSW , Australia"},{"name":"Prince of Wales Clinical School, University of New South Wales , Sydney, NSW , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Peate","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Prince of Wales Hospital , Sydney, NSW , Australia"},{"name":"Prince of Wales Clinical School, University of New South Wales , Sydney, NSW , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bettina","family":"Meiser","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Prince of Wales Hospital , Sydney, NSW , Australia"},{"name":"Prince of Wales Clinical School, University of New South Wales , Sydney, NSW , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin C.","family":"Cheah","sequence":"additional","affiliation":[{"name":"Neuroscience Research Australia , Sydney, NSW , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shab","family":"Mireskandari","sequence":"additional","affiliation":[{"name":"Centre for Medical Psychology & Evidence-based Decision-making (CeMPED), The University of Sydney , Sydney, NSW , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Friedlander","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Prince of Wales Hospital , Sydney, NSW , Australia"},{"name":"Prince of Wales Clinical School, University of New South Wales , Sydney, NSW , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,10,1]]},"reference":[{"key":"2024032602331246500_bib1","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1177\/107327480200900603","article-title":"Chemotherapy-induced amenorrhea and fertility in women undergoing adjuvant treatment for breast cancer","volume":"9","author":"Minton","year":"2002","journal-title":"Cancer Control"},{"key":"2024032602331246500_bib2","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1200\/JCO.1996.14.5.1718","article-title":"Ovarian function in premenopausal women treated with adjuvant chemotherapy for breast cancer","volume":"14","author":"Bines","year":"1996","journal-title":"J Clin Oncol"},{"key":"2024032602331246500_bib3","doi-asserted-by":"crossref","first-page":"2365","DOI":"10.1200\/JCO.1999.17.8.2365","article-title":"Risk of menopause during the first year after breast cancer diagnosis","volume":"17","author":"Goodwin","year":"1999","journal-title":"J Clin Oncol"},{"key":"2024032602331246500_bib4","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1093\/annonc\/mdn353","article-title":"Practical clinical guidelines for assessing and managing menopausal symptoms after breast cancer","volume":"19","author":"Hickey","year":"2008","journal-title":"Ann Oncol"},{"key":"2024032602331246500_bib5","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1177\/107327480100800508","article-title":"Sexual functioning in breast cancer survivors","volume":"8","author":"Thors","year":"2001","journal-title":"Cancer Control"},{"key":"2024032602331246500_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1023\/A:1008298615272","article-title":"Sexual dysfunction in treated breast cancer patients","volume":"8","author":"Barni","year":"1997","journal-title":"Ann Oncol"},{"key":"2024032602331246500_bib7","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1200\/JCO.1998.16.2.501","article-title":"Life after breast cancer: Understanding women's health-related quality of life and sexual functioning","volume":"16","author":"Ganz","year":"1998","journal-title":"J Clin Oncol"},{"key":"2024032602331246500_bib8","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1200\/JCO.1998.16.4.1380","article-title":"Quality of life and preferences for treatment following systemic adjuvant therapy for early-stage breast cancer","volume":"16","author":"Lindley","year":"1998","journal-title":"J Clin Oncol"},{"key":"2024032602331246500_bib9","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1097\/00005053-199905000-00001","article-title":"Does vaginismus exist? A critical review of the literature","volume":"187","author":"Reissing","year":"1999","journal-title":"J Nerv Ment Dis"},{"key":"2024032602331246500_bib10","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.ejon.2005.10.007","article-title":"Information needs and experiences: An audit of UK cancer patients","volume":"10","author":"Cox","year":"2006","journal-title":"Eur J Oncol Nurs"},{"key":"2024032602331246500_bib11","doi-asserted-by":"crossref","first-page":"224","DOI":"10.5694\/j.1326-5377.2007.tb00877.x","article-title":"Communicating about patient sexuality and intimacy after cancer: Mismatched expectations and unmet needs","volume":"186","author":"Hordern","year":"2007","journal-title":"Med J Aust"},{"key":"2024032602331246500_bib12","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/S0140-6736(04)15493-7","article-title":"HABITS (hormonal replacement therapy after breast cancer-is it safe?), a randomised comparison: Trial stopped","volume":"363","author":"Holmberg","year":"2004","journal-title":"Lancet"},{"key":"2024032602331246500_bib13","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1093\/jnci\/dji071","article-title":"Menopausal hormone therapy after breast cancer: The Stockholm randomized trial","volume":"97","author":"Schoultz","year":"2005","journal-title":"J Natl Cancer Inst"},{"key":"2024032602331246500_bib14","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1093\/annonc\/mdj127","article-title":"Caution: Vaginal estradiol appears to be contraindicated in postmenopausal women on adjuvant aromatase inhibitors","volume":"17","author":"Kendall","year":"2006","journal-title":"Ann Oncol"},{"key":"2024032602331246500_bib15","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1093\/jnci\/92.13.1054","article-title":"Managing menopausal symptoms in breast cancer survivors: Results of a randomized controlled trial","volume":"92","author":"Ganz","year":"2000","journal-title":"J Natl Cancer Inst"},{"key":"2024032602331246500_bib16","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1111\/j.1743-6109.2010.01988.x","article-title":"Simple strategies for vaginal health promotion in cancer survivors","volume":"8","author":"Carter","year":"2011","journal-title":"J Sex Med"},{"key":"2024032602331246500_bib17","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1111\/j.1743-6109.2010.02067.x","article-title":"Association of lubricant use with women's sexual pleasure, sexual satisfaction, and genital symptoms: A prospective daily diary study","volume":"8","author":"Herbenick","year":"2011","journal-title":"J Sex Med"},{"key":"2024032602331246500_bib18","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1111\/j.1743-6109.2011.02543.x","article-title":"To lube or not to lube: Experiences and perceptions of lubricant use in women with and without dyspareunia","volume":"9","author":"Sutton","year":"2012","journal-title":"J Sex Med"},{"key":"2024032602331246500_bib19","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1097\/OLQ.0b013e3181644669","article-title":"Mucosal irritation potential of personal lubricants relates to product osmolality as detected by the slug mucosal irritation assay","volume":"35","author":"Adriaens","year":"2008","journal-title":"Sex Transm Dis"},{"key":"2024032602331246500_bib20","volume-title":"Women's sexual function and dysfunction: Study, diagnosis and treatment","author":"Goldstein","year":"2006"},{"key":"2024032602331246500_bib21","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1016\/S0015-0282(16)41350-6","article-title":"The effect of vaginal lubricants on sperm motility in vitro","volume":"26","author":"Goldenberg","year":"1975","journal-title":"Fertil Steril"},{"key":"2024032602331246500_bib22","doi-asserted-by":"crossref","first-page":"3351","DOI":"10.1093\/humrep\/13.12.3351","article-title":"The effects of coital lubricants on sperm motility in vitro","volume":"13","author":"Andreson","year":"1998","journal-title":"Hum Reprod"},{"key":"2024032602331246500_bib23","first-page":"400","article-title":"Vaginal lubricants for the infertile couple: Effect on sperm activity","volume":"41","author":"Kutteh","year":"1996","journal-title":"Int J Fertil Menopausal Stud"},{"key":"2024032602331246500_bib24","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1200\/JCO.1997.15.3.969","article-title":"Phase III randomized double-blind study to evaluate the efficacy of a polycarbophil-based vaginal moisturizer in women with breast cancer","volume":"15","author":"Loprinzi","year":"1997","journal-title":"J Clin Oncol"},{"key":"2024032602331246500_bib25","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/0378-5122(95)00955-8","article-title":"Replens\u00ae versus dienoestrol cream in the symptomatic treatment of vaginal atrophy in postmenopausal women","volume":"23","author":"Bygdeman","year":"2006","journal-title":"Maturitas"},{"key":"2024032602331246500_bib26","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1136\/jcp.55.6.446","article-title":"The effect of Replens\u00ae on vaginal cytology in the treatment of postmenopausal atrophy: Cytomorphology versus computerised cytometry","volume":"55","author":"Van der Laak","year":"2002","journal-title":"J Clin Pathol"},{"key":"2024032602331246500_bib27","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1002\/bjs.6303","article-title":"Systemic review of randomized controlled trials of the effectiveness of biofeedback for pelvic floor dysfunction","volume":"95","author":"Koh","year":"2008","journal-title":"Br J Surg"},{"key":"2024032602331246500_bib28","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s10484-006-9010-x","article-title":"Pelvic floor muscle biofeedback in the treatment of urinary incontinence: A literature review","volume":"31","author":"Glazer","year":"2006","journal-title":"Appl Psychophysiol Biofeedback"},{"key":"2024032602331246500_bib29","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/j.1743-6109.2006.00393.x","article-title":"Pelvic floor involvement in male and female sexual dysfunction and the role of pelvic floor rehabilitation in treatment: A literature review","volume":"4","author":"Rosenbaum","year":"2007","journal-title":"J Sex Med"},{"key":"2024032602331246500_bib30","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0304-3959(83)90088-X","article-title":"Assessment of chronic pain. I. Aspects of the reliability and validity of the visual analogue scale","volume":"16","author":"Carlsson","year":"1983","journal-title":"Pain"},{"key":"2024032602331246500_bib31","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/BF00435972","article-title":"The Sexual Activity Questionnaire: A measure of women's sexual functioning","volume":"5","author":"Thirlaway","year":"1996","journal-title":"Qual Life Res"},{"key":"2024032602331246500_bib32","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1080\/07347330802115715","article-title":"Case-control comparison of quality of life in long-term ovarian germ cell tumor survivors: A gynecologic oncology group study","volume":"26","author":"Monahan","year":"2008","journal-title":"J Psychosoc Oncol"},{"key":"2024032602331246500_bib33","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1080\/009262300278597","article-title":"The Female Sexual Function Index (FSFI): A multidimensional self-report instrument for the assessment of female sexual function","volume":"26","author":"Rosen","year":"2000","journal-title":"J Sex Marital Ther"},{"key":"2024032602331246500_bib34","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1200\/JCO.1997.15.3.974","article-title":"Reliability and validity of the Functional Assessment of Cancer Therapy-Breast quality-of-life instrument","volume":"15","author":"Brady","year":"1997","journal-title":"J Clin Oncol"},{"key":"2024032602331246500_bib35","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1023\/A:1006263818115","article-title":"Assessment of quality of life in women undergoing hormonal therapy for breast cancer: Validation of an endocrine symptom subscale for the FACT-B","volume":"55","author":"Fallowfield","year":"1999","journal-title":"Breast Cancer Res Treat"},{"key":"2024032602331246500_bib36","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/j.1600-0447.1983.tb09716.x","article-title":"The hospital anxiety and depression scale","volume":"67","author":"Zigmond","year":"1983","journal-title":"Acta Psychiatr Scand"},{"issue":"9","key":"2024032602331246500_bib37","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD007291.pub2","article-title":"Vaginal dilator therapy for women receiving pelvic radiotherapy","author":"Miles","year":"2010","journal-title":"Cochrane Database Syst Rev"}],"container-title":["The Journal of Sexual Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1743609515301405?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1743609515301405?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jsm\/article-pdf\/10\/10\/2549\/48192658\/jsm_10_10_2549.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jsm\/article-pdf\/10\/10\/2549\/48192658\/jsm_10_10_2549.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T22:34:12Z","timestamp":1711406052000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jsm\/article\/10\/10\/2549\/6940102"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10,1]]},"references-count":37,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2013,10,1]]},"published-print":{"date-parts":[[2013,10,1]]}},"URL":"https:\/\/doi.org\/10.1111\/jsm.12156","relation":{},"ISSN":["1743-6109","1743-6095"],"issn-type":[{"value":"1743-6109","type":"electronic"},{"value":"1743-6095","type":"print"}],"subject":[],"published-other":{"date-parts":[[2013,10]]},"published":{"date-parts":[[2013,10,1]]}}}