{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T07:46:47Z","timestamp":1767858407844,"version":"3.49.0"},"reference-count":63,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2013,9,1]],"date-time":"2013-09-01T00:00:00Z","timestamp":1377993600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL71138"],"award-info":[{"award-number":["HL71138"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK83685"],"award-info":[{"award-number":["DK83685"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009821","name":"The Society for Women's Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009821","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007113","name":"Sexual Medicine Society of North America Scholar's in Sexuality Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007113","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,9,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Increased angiotensin II (AngII) levels cause hypertension, which is a major risk factor for erectile dysfunction (ED). Studies have demonstrated that increased AngII levels in penile tissue are associated with ED. A recent study showed that metformin treatment restored nitric oxide synthase (NOS) protein expression in penile tissue in obese rats; however, whether metformin treatment can be beneficial and restore erectile function in a model of ED has not yet been established.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Aim<\/jats:title>\n                  <jats:p>The goal of this study was to test the hypothesis that AngII induces ED by means of increased corpus cavernosum contraction, and that metformin treatment will reverse ED in AngII-treated rats.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Male Sprague-Dawley rats were implanted with mini-osmotic pumps containing saline or AngII (70ng\/minute, 28 days). Animals were then treated with metformin or vehicle during the last week of AngII infusion.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main Outcome Measures<\/jats:title>\n                  <jats:p>Intracavernosal pressure; corpus cavernosum contraction and relaxation; nNOS protein expression; extracellular signal-regulated kinase (ERK1\/2), AMP-activated protein kinase (AMPK), and eNOS protein expression and phosphorylation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>AngII-induced ED was accompanied with an increase in corpus cavernosum contractility, decreased nitrergic relaxation, and increased ERK1\/2 phosphorylation. Metformin treatment improved erectile function in the AngII-treated rats by reversing the increased contraction and decreased relaxation. Metformin treatment also resulted in an increase in eNOS phosphorylation at ser1177.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Metformin treatment increased eNOS phosphorylation and improved erectile function in AngII hypertensive rats by reestablishing normal cavernosal smooth muscle tone.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1111\/jsm.12245","type":"journal-article","created":{"date-parts":[[2013,7,24]],"date-time":"2013-07-24T22:31:58Z","timestamp":1374705118000},"page":"2154-2164","source":"Crossref","is-referenced-by-count":30,"title":["Metformin Treatment Improves Erectile Function in an Angiotensin II Model of Erectile Dysfunction"],"prefix":"10.1093","volume":"10","author":[{"given":"Hicham","family":"Labazi","sequence":"first","affiliation":[{"name":"Georgia Health Sciences University \u00a0 , Augusta, GA , USA"},{"name":"Physiology Department \u00a0 , Augusta, GA , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brandi M.","family":"Wynne","sequence":"additional","affiliation":[{"name":"Georgia Health Sciences University \u00a0 , Augusta, GA , USA"},{"name":"Physiology Department \u00a0 , Augusta, GA , USA"},{"name":"Emory University \u00a0 , Atlanta, GA , USA"},{"name":"School of Medicine, Nephrology \u00a0 , Atlanta, GA , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rita","family":"Tostes","sequence":"additional","affiliation":[{"name":"University of Sa\u00f5 Paulo \u00a0 \u00a0 , Sao Paulo , Brazil"},{"name":"Medical School of Ribeir\u00e3o Preto \u00a0 \u00a0 , Sao Paulo , Brazil"},{"name":"Department of Pharmacology \u00a0 \u00a0 , Sao Paulo , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. Clinton","family":"Webb","sequence":"additional","affiliation":[{"name":"Georgia Health Sciences University \u00a0 , Augusta, GA , USA"},{"name":"Physiology Department \u00a0 , Augusta, GA , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2013,9,1]]},"reference":[{"key":"2024032602343411700_bb0010","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/S0022-5347(17)34871-1","article-title":"Impotence and its medical and psychosocial correlates: Results of the Massachusetts Male Aging Study","volume":"151","author":"Feldman","year":"1994","journal-title":"J Urol"},{"key":"2024032602343411700_bb0015","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1185\/030079904125003467","article-title":"The multinational Men's Attitudes to Life Events and Sexuality (MALES) study: I. 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