{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T22:54:35Z","timestamp":1789512875740,"version":"build-2803163510"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T00:00:00Z","timestamp":1383264000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Auxilium Pharmaceuticals"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,11,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Peyronie's disease (PD) is a localized penile collagen disorder of the tunica albuginea associated with significant physical deformity and psychological impairment. Current understanding of pretreatment characteristics in patients with chronic PD is limited by small samples, varied quality of assessments, and the lack of a PD-specific, validated measure of the psychosexual impact of PD.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Reporting baseline demographic and disease characteristics of the large multinational cohort of subjects with chronic PD who participated in the collagenase clostridium histolyticum (CCH, an investigational intralesional injection and minimally invasive intervention) phase 3 clinical study program. Findings from well-defined assessments, including the Peyronie's Disease Questionnaire (PDQ), the first validated PD-specific patient-reported measure of psychosexual impact, are reported.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Subjects included men \u226518 years old with PD symptoms \u226512 months and penile deformity between 30\u00b0 and 90\u00b0. Analysis data included demographics, disease history, and psychosexual impact.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main Outcome Measures<\/jats:title>\n                  <jats:p>Penile deformity, disease symptoms, the International Index of Erectile Function, and the PDQ were assessed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Eight hundred thirty-two subjects were enrolled from 64 sites across the United States and Australia. The mean age was 57.7 years; mean PD duration was 4.1 years. The majority of subjects had penile deformity \u226460\u00b0 (77.3%); mean penile deformity was 50.5\u00b0. Subjects reported having intercourse a mean of 10.2 times in the previous 3 months, 70.8% reported difficulty in performing vaginal intercourse, and 80.4% reported less frequent vaginal intercourse. Approximately 71.5% of subjects with severe (&amp;gt;60\u00b0) and 58.1% of subjects with mild\/moderate (\u226460\u00b0) penile deformity were \u201cvery bothered\u201d or \u201cextremely bothered\u201d upon last look at their erect penis (P = 0.0041), as measured by the PDQ.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>These data add to the body of knowledge regarding the clinical impact of chronic phase PD, including the PD-specific patient-reported psychosexual symptoms, using a large multinational chronic PD cohort in the CCH phase 3 clinical program. Gelbard M, Hellstrom WJG, McMahon CG, Levine LA, Smith T, Tursi J, Kaufman G, and Goldstein I. Baseline characteristics from an ongoing phase 3 study of collagenase clostridium histolyticum in patients with Peyronie's disease. J Sex Med 2013;10:2822\u20132831.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1111\/jsm.12312","type":"journal-article","created":{"date-parts":[[2013,10,11]],"date-time":"2013-10-11T22:10:07Z","timestamp":1381529407000},"page":"2822-2831","source":"Crossref","is-referenced-by-count":45,"title":["Baseline Characteristics from an Ongoing Phase 3 Study of Collagenase Clostridium Histolyticum in Patients with Peyronie's Disease"],"prefix":"10.1093","volume":"10","author":[{"given":"Martin","family":"Gelbard","sequence":"first","affiliation":[{"name":"Urology Associates Medical Group , Burbank, CA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wayne J.G.","family":"Hellstrom","sequence":"additional","affiliation":[{"name":"Tulane University Health Sciences Center , New Orleans, LA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris G.","family":"McMahon","sequence":"additional","affiliation":[{"name":"Australia Center for Sexual Health , St Leonards, NSW , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence A.","family":"Levine","sequence":"additional","affiliation":[{"name":"Rush University , Chicago, IL , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ted","family":"Smith","sequence":"additional","affiliation":[{"name":"Auxilium Pharmaceuticals , Chesterbrook, PA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Tursi","sequence":"additional","affiliation":[{"name":"Auxilium Pharmaceuticals , Chesterbrook, PA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Kaufman","sequence":"additional","affiliation":[{"name":"Auxilium Pharmaceuticals , Chesterbrook, PA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irwin","family":"Goldstein","sequence":"additional","affiliation":[{"name":"San Diego Sexual Medicine , San Diego, CA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,11,1]]},"reference":[{"key":"2024032602334639000_bib1","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/ijir.2008.30","article-title":"Peyronie's disease: A critical appraisal of current diagnosis and treatment","volume":"20","author":"Smith","year":"2008","journal-title":"Int J Impot Res"},{"key":"2024032602334639000_bib2","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/ncpuro0201","article-title":"Mechanisms of disease: New insights into the cellular and molecular pathology of Peyronie's disease","volume":"2","author":"Gonzalez-Cadavid","year":"2005","journal-title":"Nat Clin Pract Urol"},{"key":"2024032602334639000_bib3","doi-asserted-by":"crossref","first-page":"397","DOI":"10.2164\/jandrol.108.006221","article-title":"Medical management of Peyronie's disease","volume":"30","author":"Hellstrom","year":"2009","journal-title":"J Androl"},{"key":"2024032602334639000_bib4","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.ucl.2007.08.017","article-title":"Peyronie's disease","volume":"34","author":"Taylor","year":"2007","journal-title":"Urol Clin North Am"},{"issue":"suppl 5","key":"2024032602334639000_bib5","doi-asserted-by":"crossref","first-page":"S93","DOI":"10.1038\/sj.ijir.3901082","article-title":"Expanding the paradigm for plaque development in Peyronie's disease","volume":"15","author":"Mulhall","year":"2003","journal-title":"Int J Impot Res"},{"key":"2024032602334639000_bib6","doi-asserted-by":"crossref","first-page":"2359","DOI":"10.1111\/j.1743-6109.2010.01850.x","article-title":"The management of Peyronie's disease: Evidence-based 2010 guidelines","volume":"7","author":"Ralph","year":"2010","journal-title":"J Sex Med"},{"key":"2024032602334639000_bib7","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/S0022-5347(17)37988-0","article-title":"The incidence of Peyronie's disease in Rochester, Minnesota, 1950 through 1984","volume":"146","author":"Lindsay","year":"1991","journal-title":"J Urol"},{"key":"2024032602334639000_bib8","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1046\/j.1464-4096.2001.02436.x","article-title":"The prevalence of Peyronie's disease: Results of a large survey","volume":"88","author":"Schwarzer","year":"2001","journal-title":"BJU Int"},{"key":"2024032602334639000_bib9","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1159\/000049830","article-title":"Peyronie's disease: Prevalence and association with cigarette smoking. A multicenter population-based study in men aged 50\u201369 years","volume":"40","author":"La Pera","year":"2001","journal-title":"Eur Urol"},{"key":"2024032602334639000_bib10","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/sj.ijir.3900727","article-title":"Prevalence of Peyronie's disease in men over 50-y-old from Southern Brazil","volume":"13","author":"Rhoden","year":"2001","journal-title":"Int J Impot Res"},{"key":"2024032602334639000_bib11","doi-asserted-by":"crossref","first-page":"2350","DOI":"10.1097\/01.ju.0000127744.18878.f1","article-title":"Subjective and objective analysis of the prevalence of Peyronie's disease in a population of men presenting for prostate cancer screening","volume":"171","author":"Mulhall","year":"2004","journal-title":"J Urol"},{"key":"2024032602334639000_bib12","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.eururo.2005.10.026","article-title":"Prevalence of Peyronie's disease among patients with erectile dysfunction","volume":"49","author":"El-Sakka","year":"2006","journal-title":"Eur Urol"},{"key":"2024032602334639000_bib13","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1097\/01.ju.0000170231.51306.32","article-title":"Peyronie's disease in diabetic patients being screened for erectile dysfunction","volume":"174","author":"El-Sakka","year":"2005","journal-title":"J Urol"},{"key":"2024032602334639000_bib14","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/sj.ijir.3901518","article-title":"The prevalence of Peyronie's disease in diabetic patients with erectile dysfunction","volume":"19","author":"Arafa","year":"2007","journal-title":"Int J Impot Res"},{"key":"2024032602334639000_bib15","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1016\/S0022-5347(01)64222-8","article-title":"Penile trauma: An etiologic factor in Peyronie's disease and erectile dysfunction","volume":"158","author":"Jarow","year":"1997","journal-title":"J Urol"},{"key":"2024032602334639000_bib16","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1111\/j.1743-6109.2008.01081.x","article-title":"Peyronie's disease intervention trials: Methodological challenges and issues","volume":"6","author":"Muller","year":"2009","journal-title":"J Sex Med"},{"key":"2024032602334639000_bib17","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/j.1743-6109.2006.00404.x","article-title":"Measurement of penile curvature in Peyronie's disease patients: Comparison of three methods","volume":"4","author":"Ohebshalom","year":"2007","journal-title":"J Sex Med"},{"key":"2024032602334639000_bib18","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1111\/j.1743-6109.2008.01158.x","article-title":"Correlation of degree of penile curvature between patient estimates and objective measures among men with Peyronie's disease","volume":"6","author":"Bacal","year":"2009","journal-title":"J Sex Med"},{"key":"2024032602334639000_bib19","doi-asserted-by":"crossref","first-page":"3446","DOI":"10.1111\/j.1743-6109.2011.02501.x","article-title":"Penile duplex ultrasonography in men with Peyronie's disease: Is it veno-occlusive dysfunction or poor cavernosal arterial inflow that contributes to erectile dysfunction?","volume":"8","author":"Chung","year":"2011","journal-title":"J Sex Med"},{"key":"2024032602334639000_bib20","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1111\/j.1743-6109.2008.00949.x","article-title":"Risk factors for emotional and relationship problems in Peyronie's disease","volume":"5","author":"Smith","year":"2008","journal-title":"J Sex Med"},{"key":"2024032602334639000_bib21","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1111\/j.1743-6109.2008.00883.x","article-title":"Impact of Peyronie's disease on sexual and psychosocial functioning: Qualitative findings in patients and controls","volume":"5","author":"Rosen","year":"2008","journal-title":"J Sex Med"},{"key":"2024032602334639000_bib22","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1111\/j.1743-6109.2008.00895.x","article-title":"The chronology of depression and distress in men with Peyronie's disease","volume":"5","author":"Nelson","year":"2008","journal-title":"J Sex Med"},{"key":"2024032602334639000_bib23","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1038\/sj.ijir.3901247","article-title":"Incidentally diagnosed Peyronie's disease in men presenting with erectile dysfunction","volume":"16","author":"Kadioglu","year":"2004","journal-title":"Int J Impot Res"},{"key":"2024032602334639000_bib24","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1111\/j.1743-6109.2010.02072.x","article-title":"Risk factors of Peyronie's disease. What does our clinical experience show?","volume":"8","author":"Casabe","year":"2011","journal-title":"J Sex Med"},{"key":"2024032602334639000_bib25","article-title":"Guidance for industry patient-reported outcome measures: Use in medical product development to support labeling claims","year":"2009"},{"key":"2024032602334639000_bib26","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.juro.2013.01.090","article-title":"Bother and distress associated with Peyronie's disease: Validation of the Peyronie's disease questionnaire","volume":"190","author":"Hellstrom","year":"2013","journal-title":"J Urol"},{"key":"2024032602334639000_bib27","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/S0090-4295(97)00238-0","article-title":"The International Index of Erectile Function (IIEF): A multidimensional scale for assessment of erectile dysfunction","volume":"49","author":"Rosen","year":"1997","journal-title":"Urology"},{"key":"2024032602334639000_bib28","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/S0090-4295(99)00099-0","article-title":"Diagnostic evaluation of the erectile function domain of the International Index of Erectile Function","volume":"54","author":"Cappelleri","year":"1999","journal-title":"Urology"},{"key":"2024032602334639000_bib29","volume-title":"Statistical power analysis for the behavioral sciences","author":"Cohen","year":"1988"},{"key":"2024032602334639000_bib30","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1016\/S0022-5347(06)00270-9","article-title":"An analysis of the natural history of Peyronie's disease","volume":"175","author":"Mulhall","year":"2006","journal-title":"J Urol"},{"key":"2024032602334639000_bib31","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/S0022-5347(05)64578-8","article-title":"A retrospective review of 307 men with Peyronie's disease","volume":"168","author":"Kadioglu","year":"2002","journal-title":"J Urol"},{"key":"2024032602334639000_bib32","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/sj.ijir.3900635","article-title":"Peyronie's disease in men under age 40: Characteristics and outcome","volume":"13","author":"Tefekli","year":"2001","journal-title":"Int J Impot Res"},{"key":"2024032602334639000_bib33","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1002\/j.1939-4640.2003.tb02634.x","article-title":"Peyronie disease in younger men: Characteristics and treatment results","volume":"24","author":"Levine","year":"2003","journal-title":"J Androl"},{"key":"2024032602334639000_bib34","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1111\/j.1743-6109.2006.00344.x","article-title":"Defining the clinical characteristics of Peyronie's disease in young men","volume":"4","author":"Deveci","year":"2007","journal-title":"J Sex Med"},{"key":"2024032602334639000_bib35","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1111\/j.1743-6109.2011.02502.x","article-title":"Peyronie's disease in teenagers","volume":"9","author":"Tal","year":"2012","journal-title":"J Sex Med"},{"key":"2024032602334639000_bib36","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1016\/S0022-5347(17)39746-X","article-title":"The natural history of Peyronie's disease","volume":"144","author":"Gelbard","year":"1990","journal-title":"J Urol"},{"key":"2024032602334639000_bib37","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/sj.ijir.3900857","article-title":"The International Index of Erectile Function (IIEF): A state-of-the-science review","volume":"14","author":"Rosen","year":"2002","journal-title":"Int J Impot Res"},{"key":"2024032602334639000_bib38","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1111\/j.1743-6109.2011.02299.x","article-title":"Erectile dysfunction after plaque incision and grafting: Short-term assessment of incidence and predictors","volume":"8","author":"Flores","year":"2011","journal-title":"J Sex Med"},{"key":"2024032602334639000_bib39","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1111\/j.1743-6109.2009.01584.x","article-title":"A cross-sectional study for the analysis of clinical, sexual and laboratory conditions associated to Peyronie's disease","volume":"7","author":"Rhoden","year":"2010","journal-title":"J Sex Med"},{"key":"2024032602334639000_bib40","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1111\/j.1743-6109.2005.20113.x","article-title":"A surgical algorithm for men with combined Peyronie's disease and erectile dysfunction: Functional and satisfaction outcomes","volume":"2","author":"Mulhall","year":"2005","journal-title":"J Sex Med"},{"key":"2024032602334639000_bib41","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1111\/j.1743-6109.2006.00278.x","article-title":"Determinants of patient satisfaction following penile prosthesis surgery","volume":"3","author":"Akin-Olugbade","year":"2006","journal-title":"J Sex Med"},{"issue":"suppl 5","key":"2024032602334639000_bib42","doi-asserted-by":"crossref","first-page":"S103","DOI":"10.1038\/sj.ijir.3901083","article-title":"Establishing a standardized evaluation of the man with Peyronie's disease","volume":"15","author":"Levine","year":"2003","journal-title":"Int J Impot Res"}],"container-title":["The Journal of Sexual Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1743609515301740?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1743609515301740?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jsm\/article-pdf\/10\/11\/2822\/48192843\/jsm_10_11_2822.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jsm\/article-pdf\/10\/11\/2822\/48192843\/jsm_10_11_2822.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T02:37:00Z","timestamp":1711420620000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jsm\/article\/10\/11\/2822\/6940148"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,1]]},"references-count":42,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2013,11,1]]},"published-print":{"date-parts":[[2013,11,1]]}},"URL":"https:\/\/doi.org\/10.1111\/jsm.12312","relation":{},"ISSN":["1743-6109","1743-6095"],"issn-type":[{"value":"1743-6109","type":"electronic"},{"value":"1743-6095","type":"print"}],"subject":[],"published-other":{"date-parts":[[2013,11]]},"published":{"date-parts":[[2013,11,1]]}}}