{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T12:22:22Z","timestamp":1740140542643,"version":"3.37.3"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Fondo de Investigaciones de la Seguridad Social","award":["RD12\/0042\/0040"],"award-info":[{"award-number":["RD12\/0042\/0040"]}]},{"DOI":"10.13039\/501100008530","name":"Fondo Europeo de Desarrollo Regional","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Fondos de Investigaciones de la Seguridad Social","award":["PI12\/01818"],"award-info":[{"award-number":["PI12\/01818"]}]},{"name":"Bayer Pharmaceuticals"},{"name":"Fondo de Investigaciones de la Seguridad Social","award":["RD12\/0042\/0040"],"award-info":[{"award-number":["RD12\/0042\/0040"]}]},{"DOI":"10.13039\/501100008530","name":"Fondo Europeo de Desarrollo Regional","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Fondos de Investigaciones de la Seguridad Social","award":["PI12\/01818"],"award-info":[{"award-number":["PI12\/01818"]}]},{"name":"Bayer Pharmaceuticals"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,12,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Evidences have been suggested that phosphodiesterase type 5 (PDE5) inhibition promotes vasculoprotective benefits in patients with cardiovascular diseases.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Aim<\/jats:title>\n                  <jats:p>The aim of this study is to analyze the systemic effect of PDE5 inhibition in type 2 diabetes mellitus patients with erectile dysfunction (ED) determining changes in the expression levels of plasma proteins.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Seventeen patients with controlled type 2 diabetes mellitus and ED were included in the study. Patients received vardenafil hydrochloride 20mg on demand during 12weeks. At the beginning and 12weeks after vardenafil administration, plasma samples were collected and analyzed using proteomics.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main Outcome Measures<\/jats:title>\n                  <jats:p>International Index of Erectile Function-Erectile Function Domain (IIEF-EFD) and plasma protein expression before and after vardenafil administration. Nitrate\/nitrite release, PDE5, and soluble guanylate cyclase (sGC) expression and cyclic guanosine monophosphate (cGMP) content in cultured bovine aortic endothelial cells (BAECs).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The IIEF-EFD score was markedly improved after 12weeks of vardenafil administration. Plasma levels of alpha 1-antitrypsin isotypes 4 and 6 and \u03b2-tropomyosin were decreased, whereas apolipoprotein AI isoype 5 was increased 12weeks after vardenafil administration. Only \u03b2-tropomyosin plasma levels were inversely correlated with IIEF-EFD score. Tropomyosin has been added to cultured BAECs and after 24hours reduced the protein expression level of sGC-\u03b21 subunit and decreased the cGMP content. Tropomyosin did not modify PDE5 expression and nitric oxide release in BAECs as compared with control BAECs. Vardenafil (10\u03bcg\/mL) did not modify sGC-\u03b21 subunit expression in tropomyosin+vardenafil-incubated BAECs; however, vardenafil significantly reversed the reduction of cGMP content induced by tropomyosin.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Vardenafil administration improved erectile functionality in controlled type 2 diabetes mellitus patients with ED, which was associated with reduction of circulating plasma \u03b2-tropomyosin levels. Tropomyosin affected by itself the cGMP generating system suggesting a possible new mechanism involved in ED. Vardenafil reversed the reduction effect of cGMP content elicited by tropomyosin in BAECs.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1111\/jsm.12324","type":"journal-article","created":{"date-parts":[[2013,10,12]],"date-time":"2013-10-12T01:03:35Z","timestamp":1381539815000},"page":"3110-3120","source":"Crossref","is-referenced-by-count":4,"title":["Vardenafil Improves Penile Erection in Type 2 Diabetes Mellitus Patients with Erectile Dysfunction: Role of Tropomyosin"],"prefix":"10.1093","volume":"10","author":[{"given":"Jose J.","family":"Zamorano-Le\u00f3n","sequence":"first","affiliation":[{"name":"Cardiovascular Research Unit \u00a0 \u00a0 , Madrid , Spain"},{"name":"Cardiology Department of Hospital Cl\u00ednico San Carlos de Madrid \u00a0 \u00a0 , Madrid , Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria del Hospital Cl\u00ednico San Carlos (IdISSC) \u00a0 \u00a0 , Madrid , 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