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Fifty-seven FtMs were treated with T (1,000 mg) for 12 weeks, after which anthropometric and metabolic parameters and mitochondrial function were evaluated.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main Outcome Measures<\/jats:title>\n                  <jats:p>Anthropometric and metabolic parameters were evaluated. Mitochondrial function was studied by assessing mitochondrial oxygen (O2) consumption, membrane potential, reactive oxygen species (ROS) production, glutathione levels (GSH), and the reduced glutathione\/oxidized glutathione (GSH)\/(GSSG) ratio in polymorphonuclear cells.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>T treatment led to mitochondrial impairment in FtMs as a result of a decrease in mitochondria O2 consumption, the membrane potential, GSH levels, and the (GSH)\/(GSSG) ratio and an increase in ROS production. Mitochondrial O2 consumption and membrane potential negatively correlated with T levels, which was further confirmed that the T treatment had induced mitochondrial dysfunction. T also produced a significant increase in total testosterone, free androgenic index, and atherogenic index of plasma, and a decrease in sex hormone-binding globulin and high-density lipoprotein cholesterol.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Treatment of FtMs with T can induce impairment of mitochondrial function and a state of oxidative stress. This effect should be taken into account in order to modulate possible comorbidities in these patients.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1111\/jsm.12376","type":"journal-article","created":{"date-parts":[[2013,11,20]],"date-time":"2013-11-20T11:54:03Z","timestamp":1384948443000},"page":"454-461","source":"Crossref","is-referenced-by-count":24,"title":["Mitochondrial Impairment and Oxidative Stress in Leukocytes after Testosterone Administration to Female-To-Male Transsexuals"],"prefix":"10.1093","volume":"11","author":[{"given":"V\u00edctor M.","family":"Victor","sequence":"first","affiliation":[{"name":"Endocrinology Service \u00a0 \u00a0 , Valencia , Spain"},{"name":"Foundation for the Promotion of Healthcare and Biomedical Research in the Valencian Community (FISABIO) \u00a0 \u00a0 , Valencia , Spain"},{"name":"University Hospital Doctor Peset \u00a0 \u00a0 , Valencia , Spain"},{"name":"Endocrinology Service \u00a0 , Valencia , Spain"},{"name":"University Hospital Doctor Peset \u00a0 , Valencia , Spain"},{"name":"Institute of Health Research INCLIVA , Valencia , Spain"},{"name":"Department of Pharmacology and CIBER CB06\/04\/0071 Research Group, CIBER Hepatic and Digestive Diseases \u00a0 , Valencia , Spain"},{"name":"University of Valencia \u00a0 , Valencia , Spain"},{"name":"Department of Physiology, Faculty of Medicine \u00a0 , Valencia , Spain"},{"name":"University of Valencia \u00a0 , Valencia , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milagros","family":"Rocha","sequence":"additional","affiliation":[{"name":"Endocrinology Service \u00a0 \u00a0 , Valencia , Spain"},{"name":"Foundation for the Promotion of Healthcare and Biomedical Research in the Valencian Community (FISABIO) \u00a0 \u00a0 , Valencia , Spain"},{"name":"University Hospital Doctor Peset \u00a0 \u00a0 , Valencia , Spain"},{"name":"Endocrinology Service \u00a0 , Valencia , Spain"},{"name":"University Hospital Doctor Peset \u00a0 , Valencia , Spain"},{"name":"Institute of Health Research INCLIVA , Valencia , Spain"},{"name":"Department of Pharmacology and CIBER CB06\/04\/0071 Research Group, CIBER Hepatic and Digestive Diseases \u00a0 , Valencia , Spain"},{"name":"University of Valencia \u00a0 , Valencia , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celia","family":"Ba\u00f1uls","sequence":"additional","affiliation":[{"name":"Endocrinology Service \u00a0 \u00a0 , Valencia , Spain"},{"name":"Foundation for the Promotion of Healthcare and Biomedical Research in the Valencian Community (FISABIO) \u00a0 \u00a0 , Valencia , Spain"},{"name":"University Hospital Doctor Peset \u00a0 \u00a0 , Valencia , Spain"},{"name":"Endocrinology Service \u00a0 , Valencia , Spain"},{"name":"University Hospital Doctor Peset \u00a0 , Valencia , Spain"},{"name":"Institute of Health Research INCLIVA , Valencia , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"Rovira-Llopis","sequence":"additional","affiliation":[{"name":"Endocrinology Service \u00a0 \u00a0 , Valencia , Spain"},{"name":"Foundation for the Promotion of Healthcare and Biomedical Research in the Valencian Community (FISABIO) \u00a0 \u00a0 , Valencia , Spain"},{"name":"University Hospital Doctor Peset \u00a0 \u00a0 , Valencia , Spain"},{"name":"Endocrinology Service \u00a0 , Valencia , Spain"},{"name":"University Hospital Doctor Peset \u00a0 , Valencia , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelino","family":"G\u00f3mez","sequence":"additional","affiliation":[{"name":"Endocrinology Service \u00a0 , Valencia , Spain"},{"name":"University Hospital Doctor Peset \u00a0 , Valencia , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Hern\u00e1ndez-Mijares","sequence":"additional","affiliation":[{"name":"Endocrinology Service \u00a0 \u00a0 , Valencia , Spain"},{"name":"Foundation for the Promotion of Healthcare and Biomedical Research in the Valencian Community (FISABIO) \u00a0 \u00a0 , Valencia , Spain"},{"name":"University Hospital Doctor Peset \u00a0 \u00a0 , Valencia , Spain"},{"name":"Endocrinology Service \u00a0 , Valencia , Spain"},{"name":"University Hospital Doctor Peset \u00a0 , Valencia , Spain"},{"name":"Institute of Health Research INCLIVA , Valencia , Spain"},{"name":"Department of Medicine, Faculty of Medicine \u00a0 , Valencia , Spain"},{"name":"University of Valencia \u00a0 , Valencia , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,2,1]]},"reference":[{"key":"2024032602355078800_bib1","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1111\/j.1743-6109.2011.02564.x","article-title":"Is hormonal therapy associated with better quality of life in transsexuals? 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