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The age-matched ED and non-ED population were identified by using International Index of Erectile Function-5 (IIEF-5). All subjects with acute and\/or chronic diseases (including diagnosed hypertension and diabetes) and long-term pharmacotherapy were excluded. Nocturnal penile tumescence and rigidity (NPTR), systemic vascular parameters and biochemical indicators related to metabolism were assessed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main Outcome Measures<\/jats:title>\n                  <jats:p>Comparison analysis and logistic regression analysis were conducted among WME-NS, ED and non-ED population.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In total, 78 WME-NS cases (mean 28.99 \u00b1 5.92 years), 179 ED cases (mean 30.69 \u00b1 5.21 years) and 43 non-ED cases (mean 28.65 \u00b1 4.30 years) were screened for analysis. Compared with non-ED group, WME-NS group had higher prevalence of early ED risk factors including endothelial dysfunction, insulin resistance, high level of glycosylated serum protein and abnormal NPTR. Multivariable-adjusted logistic regression analysis showed endothelia dysfunction (odds ratio: 8.83 vs. 17.11, both P &amp;lt; 0.001) was the independent risk factor for both WME-NS and ED.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Weaker masturbatory erection may be a sign of early cardiovascular risk associated with ED in young men without sexual intercourse. More studies are warranted to elucidate the clinical benefits by targeting these formulated strategies.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1111\/jsm.12460","type":"journal-article","created":{"date-parts":[[2014,3,4]],"date-time":"2014-03-04T02:56:38Z","timestamp":1393901798000},"page":"1519-1526","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Weaker Masturbatory Erection May Be a Sign of Early Cardiovascular Risk Associated with Erectile Dysfunction in Young Men Without Sexual Intercourse"],"prefix":"10.1093","volume":"11","author":[{"given":"Yan-Ping","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Urology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University \u00a0 , Shanghai , China"},{"name":"Shanghai Institute of Andrology \u00a0 , Shanghai , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Urology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University \u00a0 , Shanghai , China"},{"name":"Shanghai Institute of Andrology \u00a0 , Shanghai , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng-Juan","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Ultrasound \u00a0 , Guangzhou , China"},{"name":"The First Hospital Affiliated Sun Yat-Sen University \u00a0 , Guangzhou , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng-Fu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Urology \u00a0 , Guangzhou , China"},{"name":"The First Hospital Affiliated Sun Yat-Sen University \u00a0 , Guangzhou , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Ouyang","sequence":"additional","affiliation":[{"name":"Department of Urology \u00a0 , Guangzhou , China"},{"name":"The First Hospital Affiliated Sun Yat-Sen University \u00a0 , Guangzhou , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Hua","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Urology \u00a0 , Guangzhou , China"},{"name":"The First Hospital Affiliated Sun Yat-Sen University \u00a0 , Guangzhou , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Ran","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Urology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University \u00a0 , Shanghai , China"},{"name":"Shanghai Institute of Andrology \u00a0 , Shanghai , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,6,1]]},"reference":[{"key":"2024032602360475300_bib1","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1185\/030079904125003467","article-title":"The multinational men's attitudes to life events and sexuality (males) study: I. 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