{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T01:29:49Z","timestamp":1775093389303,"version":"3.50.1"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T00:00:00Z","timestamp":1409529600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Intravesical instillation with a hyaluronic acid (HA) solution is an effective treatment for interstitial cystitis\/bladder pain syndrome (IC\/BPS), but its impact on sexual functioning of patients is not known.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Aim<\/jats:title>\n                  <jats:p>The aim of this study was to evaluate the changes in sexual function of women with refractory IC\/BPS who underwent a second-line intravesical HA therapy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A total of 103 women diagnosed with refractory IC\/BPS were enrolled in this prospective, multicenter study. Sexual function was evaluated using the short form of the Pelvic Organ Prolapse\/Urinary Incontinence Sexual Function Questionnaire (PISQ-9). Bladder-related symptoms and bother were assessed by the Interstitial Cystitis Symptom Index (ICSI) and Interstitial Cystitis Problem Index (ICPI), and a pain visual analog scale (VAS), respectively. Data were analyzed with univariate methods or multivariate logistic regression analysis accordingly.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main Outcomes Measures<\/jats:title>\n                  <jats:p>Changes in PISQ-9, ICSI, ICPI, and pain VAS scores after treatment were assessed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Mean age and duration of symptoms was 43.6 \u00b1 11.8 and 5.1 \u00b1 5.0 years, respectively. ICSI, ICPI, and pain VAS scores were significantly (P &amp;lt; 0.001) improved after 1 month and 6 months of treatment. Of the 87 (84.5%) sexually active women evaluated, PISQ-9 total scores improved significantly (P &amp;lt; 0.001) from the baseline (mean 18.9 \u00b1 6.4), after 1 month (20.4 \u00b1 5.8), and 6-months (21.5 \u00b1 5.6) of treatment. Significantly improved PISQ-9 items included \u201cdyspareunia\u201d (P &amp;lt; 0.001) and \u201cnegative reactions\u201d (P = 0.015) during sexual intercourse, and \u201cintensity\u201d (P &amp;lt; 0.001) of sexual orgasms. After a logistic regression analysis, we found that a baseline PISQ-9 score was negatively correlated with the duration of IC\/BPS symptoms (P = 0.022). Meanwhile, the changes in PISQ-9 scores were positively correlated with the reduction in ICSI scores after treatment (P = 0.045).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Intravesical HA is an effective treatment for refractory IC\/BPS. A longer duration of IC\/BPS symptoms may be a predictor of poor sexual function. However, intravesical HA may improve sexual function along with the reduction of IC\/BPS symptoms.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1111\/jsm.12507","type":"journal-article","created":{"date-parts":[[2014,3,18]],"date-time":"2014-03-18T06:10:28Z","timestamp":1395123028000},"page":"2256-2263","source":"Crossref","is-referenced-by-count":21,"title":["Changes in Sexual Function of Women with Refractory Interstitial Cystitis\/Bladder Pain Syndrome after Intravesical Therapy with a Hyaluronic Acid Solution"],"prefix":"10.1093","volume":"11","author":[{"given":"Man-Jung","family":"Hung","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology \u00a0 , Taichung, Taiwan ,"},{"name":"Taichung Veterans General Hospital \u00a0 , Taichung, Taiwan ,"},{"name":"Department of Obstetrics and Gynecology \u00a0 , Taichung, Taiwan ,"},{"name":"Chung Shan Medical University School of Medicine \u00a0 , Taichung, Taiwan ,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsung-Hsien","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology \u00a0 , Taipei, Taiwan ,"},{"name":"Mackay Memorial Hospital \u00a0 , Taipei, Taiwan ,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Hao","family":"Lin","sequence":"additional","affiliation":[{"name":"Division of Urogynecology, Department of Obstetrics and Gynecology \u00a0 , Taoyuan, Taiwan ,"},{"name":"Chang Gung Memorial Hospital, Linkou Medical Center, Chang Gung University College of Medicine \u00a0 , Taoyuan, Taiwan ,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Chu","family":"Huang","sequence":"additional","affiliation":[{"name":"Division of Urogynecology, Department of Obstetrics and Gynecology \u00a0 , Taipei, Taiwan ,"},{"name":"Mackay Memorial Hospital \u00a0 , Taipei, Taiwan ,"},{"name":"Department of Nursing \u00a0 , Taipei, Taiwan ,"},{"name":"Mackay, Medicine, Nursing and Management College \u00a0 , Taipei, Taiwan ,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tzu-Yin","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology \u00a0 , Taipei, Taiwan ,"},{"name":"Taipei City Hospital, Branch for Women and Children \u00a0 , Taipei, Taiwan ,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun-Shuo","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology \u00a0 , Chiayi, Taiwan ,"},{"name":"Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation \u00a0 , Chiayi, Taiwan ,"},{"name":"School Of Medicine \u00a0 , Hualien, Taiwan ,"},{"name":"Tzu Chi University \u00a0 , Hualien, Taiwan ,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei-Chi","family":"Chuang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology \u00a0 , Kaohsiung, Taiwan ,"},{"name":"Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine \u00a0 , Kaohsiung, Taiwan ,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ching-Pei","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology \u00a0 , Taichung, Taiwan ,"},{"name":"Taichung Veterans General Hospital \u00a0 , Taichung, Taiwan ,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pao-Sheng","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Statistics \u00a0 , Taichung, Taiwan ,"},{"name":"Tunghai University \u00a0 , Taichung, Taiwan ,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gin-Den","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology \u00a0 , Taichung, Taiwan ,"},{"name":"Chung Shan Medical University School of Medicine \u00a0 , Taichung, Taiwan ,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2014,9,1]]},"reference":[{"key":"2024032602353762200_bib1","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/nau.10052","article-title":"Standardisation sub-committee of the International Continence Society. 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