{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T19:37:10Z","timestamp":1780083430548,"version":"3.54.0"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2014,6,1]],"date-time":"2014-06-01T00:00:00Z","timestamp":1401580800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Al-Ameen College of Pharmacy","award":["R&D\/KR-03\/2009\u201310-NMPB"],"award-info":[{"award-number":["R&D\/KR-03\/2009\u201310-NMPB"]}]},{"name":"Natural Remedies Private Limited"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Herbs have been used as an aphrodisiac since ages. Cinnamomum cassia is an important ingredient of many Ayurvedic formulations to treat male sexual disorder including erectile dysfunction (ED).<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>The objective of the present study was to evaluate erectogenic and aphrodisiac activity of methanol extract of C. cassia bark in young male rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Methanol extract of C. cassia was screened in vitro for arginase inhibition potential and IC50 was determined. Effect of the extract was observed in vitro on phenylephrine pre-contracted isolated rat corpus cavernosum smooth muscle (CCSM) at 0.1, 1, 10, and 100 \u03bcg\/mL. Young male Wistar rats were dosed with extract at 100 mg\/kg body weight for 28 days and its effects on sexual behavior and penile smooth muscle : collagen level were observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome Measure<\/jats:title><jats:p>Effect of C. cassia was studied on arginase activity in vitro and sexual behavior of young male rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>C. cassia inhibited arginase activity in vitro with an IC50 of 61.72 \u00b1 2.20 \u03bcg\/mL. The extract relaxed phenylephrine pre-contracted isolated rat CCSM up to 43% and significantly increased (P &amp;lt; 0.05) sexual function of young male rats. Treatment with the extract also increased smooth muscle level and decreased collagen level in rat penile tissue.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The study proves usefulness of methanol extract of C. cassia bark for increasing sexual function.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jsm.12535","type":"journal-article","created":{"date-parts":[[2014,4,24]],"date-time":"2014-04-24T02:51:59Z","timestamp":1398307919000},"page":"1475-1483","source":"Crossref","is-referenced-by-count":35,"title":["Effect of<i>Cinnamomum cassia<\/i>Methanol Extract and Sildenafil on Arginase and Sexual Function of Young Male Wistar Rats"],"prefix":"10.1093","volume":"11","author":[{"given":"Sumanta K.","family":"Goswami","sequence":"first","affiliation":[{"name":"Department of Pharmacology \u00a0 , Bangalore , India"},{"name":"Al-Ameen College of Pharmacy \u00a0 , Bangalore , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed N.","family":"Inamdar","sequence":"additional","affiliation":[{"name":"Department of Pharmacology \u00a0 , Bangalore , India"},{"name":"Al-Ameen College of Pharmacy \u00a0 , Bangalore , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohitash","family":"Jamwal","sequence":"additional","affiliation":[{"name":"Bioassay Lab, Research and Development Centre \u00a0 , Bangalore , India"},{"name":"Natural Remedies Private Limited \u00a0 , Bangalore , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shekhar","family":"Dethe","sequence":"additional","affiliation":[{"name":"Bioassay Lab, Research and Development Centre \u00a0 , Bangalore , India"},{"name":"Natural Remedies Private Limited \u00a0 , Bangalore , India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,6,1]]},"reference":[{"key":"2024032602355923200_bib1","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S0031-6997(24)01503-5","article-title":"Pharmacology of penile erection","volume":"53","author":"Andersson","year":"2001","journal-title":"Pharmacol Rev"},{"key":"2024032602355923200_bib2","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1038\/sj.ijir.3900725","article-title":"Erectile dysfunction is a marker for cardiovascular complications and psychological functioning in men with hypertension","volume":"13","author":"Burchardt","year":"2001","journal-title":"Int J Impot Res"},{"key":"2024032602355923200_bib3","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1097\/01.psy.0000133969.80612.71","article-title":"Erectile dysfunction: Evaluation and new treatment options","volume":"66","author":"Carson","year":"2004","journal-title":"Psychosom Med"},{"key":"2024032602355923200_bib4","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1021\/ar040183k","article-title":"Arginase: Structure, mechanism, and physiological role arginase in male and female sexual arousal","volume":"38","author":"Christianson","year":"2005","journal-title":"Acc Chem Res"},{"key":"2024032602355923200_bib5","doi-asserted-by":"crossref","first-page":"R1572","DOI":"10.1152\/ajpregu.00041.2003","article-title":"Improved erectile function after Rho-kinase inhibition in a rat castrate model of erectile dysfunction","volume":"284","author":"Wingard","year":"2003","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"2024032602355923200_bib6","doi-asserted-by":"crossref","first-page":"S273","DOI":"10.4103\/0019-5545.105550","article-title":"Vajikarana: Treatment of sexual dysfunctions based on Indian concepts","volume":"55","author":"Dalal","year":"2013","journal-title":"Indian J Psychiatry"},{"key":"2024032602355923200_bib7","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1007\/s10508-008-9444-8","article-title":"A comparative study on aphrodisiac activity of some Ayurvedic herbs in male albino rats","volume":"38","author":"Thakur","year":"2009","journal-title":"Arch Sex Behav"},{"key":"2024032602355923200_bib8","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1472-6882-3-6","article-title":"Aphrodisiac activity of 50% ethanol extracts of Myristica fragrans Houtt. 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