{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,20]],"date-time":"2024-05-20T23:31:05Z","timestamp":1716247865443},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Three decades after the first nerve-sparing radical prostatectomy, postoperative erectile dysfunction (ED) remains a challenging and common problem. Despite considerable advances and improvements in surgical techniques, full recovery of erectile function remains elusive even for young, potent men. This suggests, ipso facto, that factors other than surgical technique must be important to recovery of erectile function.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Aim<\/jats:title>\n                  <jats:p>This study aims to review evidence that the prostate is an endocrine gland with contributions to local and systemic concentrations of 5\u03b1-dihydrotestosterone (5\u03b1-DHT), a potent androgen shown to be critical to penile physiology.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Literature review of human and animal studies related to endocrine role of prostate and postoperative recovery of erectile function.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main Outcome Measures<\/jats:title>\n                  <jats:p>Effect of 5\u03b1-DHT on erectile function and recovery after surgical injury.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We advance the following hypothesis: \u201cLoss of endocrine function of the prostate, specifically reduced local 5\u03b1-DHT concentration plays a major role in the failure of full recovery of erectile function following anatomic nerve-sparing radical prostatectomy.\u201d<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>We propose two separate, yet interrelated, mechanisms whereby the loss of 5\u03b1-DHT interferes with postoperative recovery of erectile function: (i) 5\u03b1-DHT contributes to cavernous nerve integrity and its ability to recover from surgical insult. (ii) 5\u03b1-DHT is important to the structural\/functional integrity of penile tissues and erectile physiology.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1111\/jsm.12574","type":"journal-article","created":{"date-parts":[[2014,5,16]],"date-time":"2014-05-16T10:20:52Z","timestamp":1400235652000},"page":"1898-1902","source":"Crossref","is-referenced-by-count":6,"title":["Medical Hypothesis: Loss of the Endocrine Function of the Prostate Is Important to the Pathophysiology of Postprostatectomy Erectile Dysfunction"],"prefix":"10.1093","volume":"11","author":[{"given":"Ravi","family":"Kacker","sequence":"first","affiliation":[{"name":"Department of Urology \u00a0 , Brookline , USA"},{"name":"Men's Health Boston \u00a0 , Brookline , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abraham","family":"Morgentaler","sequence":"additional","affiliation":[{"name":"Department of Urology \u00a0 , Brookline , USA"},{"name":"Men's Health Boston \u00a0 , Brookline , 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