{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T17:15:56Z","timestamp":1789665356174,"version":"4.0.1"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T00:00:00Z","timestamp":1409529600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100006351","name":"North Dakota State University","doi-asserted-by":"publisher","award":["P30 GM103332-01"],"award-info":[{"award-number":["P30 GM103332-01"]}],"id":[{"id":"10.13039\/100006351","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005349","name":"American Association of Colleges of Pharmacy","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005349","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Angiotensin (Ang)-(1-7) is a recently identified vasoprotective heptapeptide, and it appears to activate the reparative functions of bone marrow\u2013derived stem\/progenitor cells (BMPCs).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Aim<\/jats:title>\n                  <jats:p>This study evaluated the effect of Ang-(1-7) in the angiogenic function of cavernosum in type 1 diabetes (T1D) and delineated the role of BMPCs in this protective function.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>T1D was induced by streptozotocin in mice, and mice with 20\u201324 weeks of diabetes were used for the study. Ang-(1-7) was administered subcutaneously by using osmotic pumps. Cavernosa, and BMPCs from peripheral blood and bone marrow were evaluated in different assay systems.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main Outcome Measures<\/jats:title>\n                  <jats:p>Angiogenic function was determined by endothelial tube formation in matrigel assay. Circulating BMPCs were enumerated by flow cytometry and proliferation was determined by BrdU incorporation. Cell-free supernatant of BMPCs were collected and tested for paracrine angiogenic effect. Expression of angiogenic factors in BMPCs and cavernosa were determined by real-time polymerase chain reaction.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Ang-(1-7) (100 nM) stimulated angiogenesis in mouse cavernosum that was partially inhibited by Mas1 receptor antagonist, A779 (10 \u03bcM) (P &amp;lt; 0.05). In cavernosa of T1D, the angiogenic responses to Ang-(1-7) (P &amp;lt; 0.005) and VEGF (100 nM) (P &amp;lt; 0.03) were diminished. Ang-(1-7) treatment for 4 weeks reversed T1D-induced decrease in the VEGF-mediated angiogenesis. Ang-(1-7) treatment increased the circulating number of BMPCs and proliferation that were decreased in T1D (P &amp;lt; 0.02). Paracrine angiogenic function of BMPCs was reduced in diabetic BMPCs, which was reversed by Ang-(1-7). In diabetic BMPCs, SDF and angiopoietin-1 were upregulated by Ang-(1-7), and in cavernosum, VEGFR1, Tie-2, and SDF were upregulated and angiopoietin-2 was down-regulated.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Ang-(1-7) stimulates angiogenic function of cavernosum in diabetes via its stimulating effects on both cavernosal microvasculature and BMPCs.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1111\/jsm.12620","type":"journal-article","created":{"date-parts":[[2014,6,24]],"date-time":"2014-06-24T05:39:21Z","timestamp":1403588361000},"page":"2153-2163","source":"Crossref","is-referenced-by-count":20,"title":["Angiotensin-(1-7) Reverses Angiogenic Dysfunction in Corpus Cavernosum by Acting on the Microvasculature and Bone Marrow\u2013Derived Cells in Diabetes"],"prefix":"10.1093","volume":"11","author":[{"given":"Neha","family":"Singh","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences \u00a0 \u00a0 , Fargo, ND , Italy"},{"name":"College of Pharmacy, Nursing, and Allied Sciences \u00a0 \u00a0 , Fargo, ND , Italy"},{"name":"North Dakota State University \u00a0 \u00a0 , Fargo, ND , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Goutham","family":"Vasam","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences \u00a0 \u00a0 , Fargo, ND , Italy"},{"name":"College of Pharmacy, Nursing, and Allied Sciences \u00a0 \u00a0 , Fargo, ND , Italy"},{"name":"North Dakota State University \u00a0 \u00a0 , Fargo, ND , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul","family":"Pawar","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences \u00a0 \u00a0 , Fargo, ND , Italy"},{"name":"College of Pharmacy, Nursing, and Allied Sciences \u00a0 \u00a0 , Fargo, ND , Italy"},{"name":"North Dakota State University \u00a0 \u00a0 , Fargo, ND , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yagna P.R.","family":"Jarajapu","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences \u00a0 \u00a0 , Fargo, ND , Italy"},{"name":"College of Pharmacy, Nursing, and Allied Sciences \u00a0 \u00a0 , Fargo, ND , Italy"},{"name":"North Dakota State University \u00a0 \u00a0 , Fargo, ND , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,9,1]]},"reference":[{"key":"2024032602364473200_bib1","doi-asserted-by":"crossref","first-page":"135","DOI":"10.2337\/diacare.19.2.135","article-title":"Prevalence of self-reported erectile dysfunction in people with long-term IDDM","volume":"19","author":"Klein","year":"1996","journal-title":"Diabetes Care"},{"key":"2024032602364473200_bib2","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1093\/ije\/29.3.524","article-title":"Erectile dysfunction in type 1 and type 2 diabetics in Italy. 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