{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T18:57:34Z","timestamp":1782932254261,"version":"3.54.5"},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Male-to-female transgender persons (trans-women) receive livelong cross-sex hormonal treatment in order to induce and maintain secondary female characteristics. One of the concerns of long-term estrogen treatment is the induction of carcinomas of estrogen-sensitive tissues such as the breast. BRCA1 mutations have been shown to account for a large proportion of inherited predispositions to breast cancer.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Aim<\/jats:title>\n                  <jats:p>The aim of this case report is to discuss the hormonal and surgical options in the treatment of trans-women with a genetic predisposition for breast cancer.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Method<\/jats:title>\n                  <jats:p>We describe a case of a trans-woman who was found to be a carrier of a BRCA1 mutation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The patient underwent a breast augmentation. She refused a prophylactic mastectomy followed by a primary breast reconstruction. She also underwent a vaginoplasty and a bilateral castration. Androgen blocking treatment was stopped after surgery; estradiol treatment however was continued.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>This case points to the importance of routine investigation of family history in trans-women. Trans-women with BRCA mutations should be carefully monitored and if cancers develop, this should be reported. Follow-up should be according to the guidelines for breast cancer screening in biological women, and the guidelines for prostate cancer and colon cancer screening in men.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1111\/jsm.12628","type":"journal-article","created":{"date-parts":[[2014,7,10]],"date-time":"2014-07-10T06:33:29Z","timestamp":1404974009000},"page":"2496-2499","source":"Crossref","is-referenced-by-count":36,"title":["Hormonal and Surgical Treatment in Trans-Women with BRCA1 Mutations: A Controversial Topic"],"prefix":"10.1093","volume":"11","author":[{"given":"Britt","family":"Colebunders","sequence":"first","affiliation":[{"name":"Department of Plastic Surgery \u00a0 , Ghent , Belgium"},{"name":"Ghent University Hospital \u00a0 , Ghent , Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy","family":"T'Sjoen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology \u00a0 , Ghent , Belgium"},{"name":"Ghent University Hospital \u00a0 , Ghent , Belgium"},{"name":"Center for Sexology and Gender Problems \u00a0 , Ghent , Belgium"},{"name":"Ghent University Hospital \u00a0 , Ghent , Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Weyers","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology \u00a0 , Ghent , Belgium"},{"name":"Ghent University Hospital \u00a0 , Ghent , Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stan","family":"Monstrey","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery \u00a0 , Ghent , Belgium"},{"name":"Ghent University Hospital \u00a0 , Ghent , Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,10,1]]},"reference":[{"key":"2024032602363215500_bib1","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1111\/jsm.12487","article-title":"Clinical review: Breast development in trans women receiving cross-sex hormones","volume":"11","author":"Wierckx","year":"2014","journal-title":"J Sex Med"},{"key":"2024032602363215500_bib2","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1093\/jnci\/94.18.1365","article-title":"Cancer risk estimates for BRCA1 mutation carriers identified in a risk evaluation program","volume":"94","author":"Brose","year":"2002","journal-title":"J Natl Cancer Inst"},{"key":"2024032602363215500_bib3","first-page":"954","volume":"43","author":"Chen","year":"2013","journal-title":"Poorer survival of male breast cancer compared with female breast cancer patients may be due to biological differences"},{"key":"2024032602363215500_bib4","doi-asserted-by":"crossref","first-page":"e53353","DOI":"10.1371\/journal.pone.0053353","article-title":"Differential expression of growth factor receptors and membrane-bound tumor markers for imaging in male and female breast cancer","volume":"8","author":"Vermeulen","year":"2013","journal-title":"PLoS ONE"},{"key":"2024032602363215500_bib5","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1002\/cncr.20312","article-title":"Breast carcinoma in men: A population-based study","volume":"101","author":"Giordano","year":"2004","journal-title":"Cancer"},{"key":"2024032602363215500_bib6","doi-asserted-by":"crossref","first-page":"3129","DOI":"10.1111\/jsm.12319","article-title":"Breast cancer development in transsexual subjects receiving cross-sex hormone treatment","volume":"10","author":"Gooren","year":"2013","journal-title":"J Sex Med"},{"key":"2024032602363215500_bib7","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.ejrad.2009.03.018","article-title":"Mammography and breast sonography in transsexual women","volume":"74","author":"Weyers","year":"2010","journal-title":"Eur J Radiol"},{"key":"2024032602363215500_bib8","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1056\/NEJM200107193450301","article-title":"Breast cancer after prophylactic bilateral mastectomy in women with a BRCA1 or BRCA2 mutation","volume":"345","author":"Meijers-Heijboer","year":"2001","journal-title":"N Engl J Med"},{"key":"2024032602363215500_bib9","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1002\/cbin.10198","article-title":"Characteristics of human adipose mesenchymal stem cells isolated from healthy and cancer affected people and their interactions with human breast cancer cell line MCF-7 in vitro","volume":"38","author":"Trivanovi\u0107","year":"2014","journal-title":"Cell Biol Int"},{"key":"2024032602363215500_bib10","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.urology.2008.06.016","article-title":"Clinical and transvaginal sonographic evaluation of the prostate in transsexual women","volume":"74","author":"Weyers","year":"2009","journal-title":"Urology"},{"key":"2024032602363215500_bib11","doi-asserted-by":"crossref","DOI":"10.1136\/bcr.02.2009.1589","article-title":"Autonomous prolactin secretion in two male-to-female transgender patients using conventional oestrogen dosages","volume-title":"BMJ Case Rep","author":"Bunck","year":"2009"}],"container-title":["The Journal of Sexual Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1743609515305683?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1743609515305683?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jsm\/article-pdf\/11\/10\/2496\/48359695\/jsm_11_10_2496.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jsm\/article-pdf\/11\/10\/2496\/48359695\/jsm_11_10_2496.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T03:12:11Z","timestamp":1711422731000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jsm\/article\/11\/10\/2496\/6958315"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10,1]]},"references-count":11,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2014,10,1]]},"published-print":{"date-parts":[[2014,10,1]]}},"URL":"https:\/\/doi.org\/10.1111\/jsm.12628","relation":{},"ISSN":["1743-6109","1743-6095"],"issn-type":[{"value":"1743-6109","type":"electronic"},{"value":"1743-6095","type":"print"}],"subject":[],"published-other":{"date-parts":[[2014,10]]},"published":{"date-parts":[[2014,10,1]]}}}