{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T09:55:59Z","timestamp":1784022959071,"version":"3.55.0"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2022,12,24]],"date-time":"2022-12-24T00:00:00Z","timestamp":1671840000000},"content-version":"vor","delay-in-days":2975,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Cardiovascular and endocrine-metabolic diseases associated with increased oxidative stress such as obesity lead to erectile dysfunction (ED). Activators of soluble guanylyl cyclase (sGC) such as BAY 60-2770 reactivate the heme-oxidized sGC in vascular diseases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This study aimed to evaluate the effects of 2-week oral intake with BAY 60-2270 on a murine model of obesity-associated ED.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>C57BL\/6 male mice were fed for 12 weeks with standard chow or high-fat diet. Lean and obese mice were treated with BAY 60-2770 (1 mg\/kg\/day, 2 weeks).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcome Measures<\/jats:title>\n                    <jats:p>Measurements of intracavernosal pressure (ICP), along with acetylcholine (10\u22129 to 10\u22125 M) and electrical field stimulation (EFS; 4\u201310 Hz)-induced corpus cavernosum relaxations in vitro, were obtained. Levels of cyclic guanosine monophosphate (cGMP), reactive oxygen species (ROS), and sGC protein expressions in cavernosal tissues were measured.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Cavernous nerve stimulation caused frequency-dependent ICP increases, which were significantly lower in obese compared with lean mice (P &amp;lt; 0.05). Two-week therapy with BAY 60-2770 fully reversed the decreased ICP in obese group. Acetylcholine-induced cavernosal relaxations were 45% lower (P &amp;lt; 0.001) in obese mice, which were fully restored by BAY 60-2770 treatment. Likewise, the EFS-induced relaxations in obese mice were restored by BAY 60-2770. Basal cGMP content in erectile tissue was 68% lower (P &amp;lt; 0.05) in obese mice, an effect normalized by BAY 60-2770. Levels of ROS were 52% higher (P &amp;lt; 0.05) whereas protein expression of \u03b11 sGC subunit was reduced in cavernosal tissue of obese mice, both of which were normalized by BAY 60-2770. In lean group, BAY 60-2770 did not significantly affect any functional, biochemical, or molecular parameter analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Two-week therapy with BAY 60-2770 restores the erectile function in obese mice that is associated with reduced ROS levels, up-regulation of \u03b11 sGC subunit, and increased cGMP levels in the erectile tissue.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jsm.12682","type":"journal-article","created":{"date-parts":[[2014,9,5]],"date-time":"2014-09-05T05:02:56Z","timestamp":1409893376000},"page":"2661-2670","source":"Crossref","is-referenced-by-count":23,"title":["Prolonged Therapy with the Soluble Guanylyl Cyclase Activator BAY 60-2770 Restores the Erectile Function in Obese Mice"],"prefix":"10.1093","volume":"11","author":[{"given":"F\u00e1bio H.","family":"Silva","sequence":"first","affiliation":[{"name":"Department of Pharmacology \u00a0 \u00a0 , Campinas ,","place":["Brazil"]},{"name":"Faculty of Medical Sciences \u00a0 \u00a0 , Campinas ,","place":["Brazil"]},{"name":"University of Campinas \u00a0 \u00a0 , Campinas ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz O.","family":"Leiria","sequence":"additional","affiliation":[{"name":"Department of Pharmacology \u00a0 \u00a0 , Campinas ,","place":["Brazil"]},{"name":"Faculty of Medical Sciences \u00a0 \u00a0 , Campinas ,","place":["Brazil"]},{"name":"University of Campinas \u00a0 \u00a0 , Campinas ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo C.","family":"Alexandre","sequence":"additional","affiliation":[{"name":"Department of Pharmacology \u00a0 \u00a0 , Campinas ,","place":["Brazil"]},{"name":"Faculty of Medical Sciences \u00a0 \u00a0 , Campinas ,","place":["Brazil"]},{"name":"University of Campinas \u00a0 \u00a0 , Campinas ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Paula C.","family":"Davel","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Cellular Biology, Physiology and Biophysics \u00a0 \u00a0 , Campinas ,","place":["Brazil"]},{"name":"Institute of Biology \u00a0 \u00a0 , Campinas ,","place":["Brazil"]},{"name":"University of Campinas \u00a0 \u00a0 , Campinas ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fab\u00edola Z.","family":"M\u00f3nica","sequence":"additional","affiliation":[{"name":"Department of Pharmacology \u00a0 \u00a0 , Campinas ,","place":["Brazil"]},{"name":"Faculty of Medical Sciences \u00a0 \u00a0 , Campinas ,","place":["Brazil"]},{"name":"University of Campinas \u00a0 \u00a0 , Campinas ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilberto","family":"De Nucci","sequence":"additional","affiliation":[{"name":"Department of Pharmacology \u00a0 \u00a0 , Campinas ,","place":["Brazil"]},{"name":"Faculty of Medical Sciences \u00a0 \u00a0 , Campinas ,","place":["Brazil"]},{"name":"University of Campinas \u00a0 \u00a0 , Campinas ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edson","family":"Antunes","sequence":"additional","affiliation":[{"name":"Department of Pharmacology \u00a0 \u00a0 , Campinas ,","place":["Brazil"]},{"name":"Faculty of Medical Sciences \u00a0 \u00a0 , Campinas ,","place":["Brazil"]},{"name":"University of Campinas \u00a0 \u00a0 , Campinas ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,11,1]]},"reference":[{"key":"2026041420271146800_bib1","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1001\/jama.1993.03510010089036","article-title":"NIH Consensus Conference. Impotence. NIH Consensus Development Panel on Impotence","volume":"270","year":"1993","journal-title":"JAMA"},{"key":"2026041420271146800_bib2","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1159\/000019929","article-title":"Is obesity an underlying factor in erectile dysfunction?","volume":"36","author":"Chung","year":"1999","journal-title":"Eur Urol"},{"key":"2026041420271146800_bib3","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/S0090-4295(00)00614-2","article-title":"Modifiable risk factors and erectile dysfunction: Can lifestyle changes modify risk?","volume":"56","author":"Derby","year":"2000","journal-title":"Urology"},{"key":"2026041420271146800_bib4","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1111\/j.1743-6109.2010.02181.x","article-title":"A survey of obesity and erectile dysfunction of men conscripted into the military in Taiwan","volume":"8","author":"Chao","year":"2011","journal-title":"J Sex Med"},{"key":"2026041420271146800_bib5","doi-asserted-by":"crossref","first-page":"2978","DOI":"10.1001\/jama.291.24.2978","article-title":"Effect of lifestyle changes on erectile dysfunction in obese men: A randomized controlled trial","volume":"291","author":"Esposito","year":"2004","journal-title":"JAMA"},{"key":"2026041420271146800_bib6","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/j.1743-6109.2009.01541.x","article-title":"Treatment of erectile dysfunction in the obese type 2 diabetic ZDF rat with adipose tissue-derived stem cells","volume":"7","author":"Garcia","year":"2010","journal-title":"J Sex Med"},{"key":"2026041420271146800_bib7","doi-asserted-by":"crossref","first-page":"H2204","DOI":"10.1152\/ajpheart.00027.2008","article-title":"Erectile dysfunction in the type II diabetic db\/db mouse: Impaired venoocclusion with altered cavernosal vasoreactivity and matrix","volume":"294","author":"Luttrell","year":"2008","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2026041420271146800_bib8","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1111\/j.1743-6109.2007.00752.x","article-title":"Adenosine actions are preserved in corpus cavernosum from obese and type II diabetic db\/db mouse","volume":"5","author":"Carneiro","year":"2008","journal-title":"J Sex Med"},{"key":"2026041420271146800_bib9","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1111\/j.1464-410X.2010.09704.x","article-title":"High-fat diet associated with obesity induces impairment of mouse corpus cavernosum responses","volume":"107","author":"Toque","year":"2011","journal-title":"BJU Int"},{"key":"2026041420271146800_bib10","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1124\/pr.111.004515","article-title":"Mechanisms of penile erection and basis for pharmacological treatment of erectile dysfunction","volume":"63","author":"Andersson","year":"2011","journal-title":"Pharmacol Rev"},{"key":"2026041420271146800_bib11","doi-asserted-by":"crossref","first-page":"3117","DOI":"10.3390\/ijms12053117","article-title":"Inflammation, oxidative stress, and obesity","volume":"12","author":"Fern\u00e1ndez-S\u00e1nchez","year":"2011","journal-title":"Int J Mol Sci"},{"key":"2026041420271146800_bib12","doi-asserted-by":"crossref","first-page":"2552","DOI":"10.1172\/JCI28371","article-title":"Targeting the heme-oxidized nitric oxide receptor for selective vasodilatation of diseased blood vessels","volume":"116","author":"Stasch","year":"2006","journal-title":"J Clin Invest"},{"key":"2026041420271146800_bib13","doi-asserted-by":"crossref","first-page":"12312","DOI":"10.1073\/pnas.0703944104","article-title":"Desensitization of soluble guanylyl cyclase, the NO receptor, by S-nitrosylation","volume":"104","author":"Sayed","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026041420271146800_bib14","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/sj.ijir.3901523","article-title":"Reactive oxygen species and erectile dysfunction: Possible role of NADPH oxidase","volume":"19","author":"Jeremy","year":"2007","journal-title":"Int J Impot Res"},{"key":"2026041420271146800_bib15","doi-asserted-by":"crossref","first-page":"3023","DOI":"10.1111\/j.1743-6109.2010.01880.x","article-title":"Hypercholesterolemia-induced erectile dysfunction: Endothelial nitric oxide synthase (eNOS) uncoupling in the mouse penis by NAD(P)H oxidase","volume":"7","author":"Musicki","year":"2010","journal-title":"J Sex Med"},{"key":"2026041420271146800_bib16","doi-asserted-by":"crossref","first-page":"3299","DOI":"10.2174\/092986711796504646","article-title":"Nitric oxide and cyclic GMP signaling pathway as a focus for drug development","volume":"18","author":"Kots","year":"2011","journal-title":"Curr Med Chem"},{"key":"2026041420271146800_bib17","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.pharmthera.2005.10.011","article-title":"Pharmacology of erectile dysfunction in man","volume":"111","author":"Cirino","year":"2006","journal-title":"Pharmacol Ther"},{"key":"2026041420271146800_bib18","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1038\/35065611","article-title":"NO-independent regulatory site on soluble guanylate cyclase","volume":"410","author":"Stasch","year":"2001","journal-title":"Nature"},{"key":"2026041420271146800_bib19","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/978-3-540-68964-5_13","article-title":"NO-independent, haem-dependent soluble guanylate ciclase stimulators","volume":"191","author":"Stasch","year":"2009","journal-title":"Handb Exp Pharmacol"},{"key":"2026041420271146800_bib20","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.2174\/138161210791164162","article-title":"Exploring the potential of NO-independent stimulators and activators of soluble guanylate cyclase for the medical treatment of erectile dysfunction","volume":"16","author":"Gur","year":"2010","journal-title":"Curr Pharm Des"},{"key":"2026041420271146800_bib21","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/S0090-4295(02)02121-0","article-title":"BAY 41\u20132272: A stimulator of soluble guanylyl cyclase induces nitric oxide-dependent penile erection in vivo","volume":"61","author":"Bischoff","year":"2003","journal-title":"Urology"},{"key":"2026041420271146800_bib22","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.ejphar.2003.08.012","article-title":"Relaxing effects induced by the soluble guanylyl cyclase stimulator BAY 41\u20132272 in human and rabbit corpus cavernosum","volume":"477","author":"Baracat","year":"2003","journal-title":"Eur J Pharmacol"},{"key":"2026041420271146800_bib23","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1161\/CIRCRESAHA.109.198234","article-title":"Nitric oxide-independent vasodilator rescues heme-oxidized soluble guanylate ciclase from proteasomal degradation","volume":"105","author":"Meurer","year":"2009","journal-title":"Circ Res"},{"key":"2026041420271146800_bib24","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1124\/jpet.110.169755","article-title":"Heme oxygenase-1 deficiency leads to alteration of soluble guanylate cyclase redox regulation","volume":"335","author":"Jones","year":"2010","journal-title":"J Pharmacol Exp Ther"},{"key":"2026041420271146800_bib25","first-page":"71","article-title":"Nitric oxide-independent activation of soluble guanylate cyclase by BAY 60-2770 in experimental liver fibrosis","volume":"58","author":"Knorr","year":"2008","journal-title":"Arzneimittelforschung"},{"key":"2026041420271146800_bib26","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1111\/j.1476-5381.2009.00263.x","article-title":"Distinct molecular requirements for activation or stabilization of soluble guanylyl cyclase upon haem oxidation-induced degradation","volume":"157","author":"Hoffmann","year":"2009","journal-title":"Br J Pharmacol"},{"key":"2026041420271146800_bib27","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1152\/ajpheart.51.2008","article-title":"Soluble guanylyl cyclase activation by HMR-1766 (ataciguat) in cells exposed to oxidative stress","volume":"295","author":"Zhou","year":"2008","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2026041420271146800_bib28","doi-asserted-by":"crossref","first-page":"3601","DOI":"10.1021\/bi301657w","article-title":"Insights into BAY 60-2770 Activation and S-Nitrosylation-dependent desensitization of soluble guanylyl cyclase via crystal structures of homologous Nostoc H-NOX domain complexes","volume":"52","author":"Kumar","year":"2013","journal-title":"Biochemistry"},{"key":"2026041420271146800_bib29","doi-asserted-by":"crossref","first-page":"H1670","DOI":"10.1152\/ajpheart.00062.2013","article-title":"The sGC activator BAY 60-2770 has potent erectile activity in the rat","volume":"304","author":"Lasker","year":"2013","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2026041420271146800_bib30","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1124\/jpet.113.211029","article-title":"Soluble guanylyl cyclase (sGC) degradation and impairment of nitric oxide-mediated responses in urethra from obese mice: Reversal by the sGC activator BAY 60-2770","volume":"349","author":"Alexandre","year":"2014","journal-title":"J Pharmacol Exp Ther"},{"key":"2026041420271146800_bib31","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.juro.2013.09.020","article-title":"The soluble guanylyl cyclase activator BAY 60-2770 ameliorates overactive bladder in obese mice","volume":"191","author":"Leiria","year":"2014","journal-title":"J Urol"},{"key":"2026041420271146800_bib32","doi-asserted-by":"crossref","first-page":"3041","DOI":"10.1111\/j.1743-6109.2012.02960.x","article-title":"Apocynin improves erectile function in diabetic rats through regulation of NADPH oxidase expression","volume":"9","author":"Li","year":"2012","journal-title":"J Sex Med"},{"key":"2026041420271146800_bib33","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1111\/jsm.12063","article-title":"Superoxide anion production by NADPH oxidase plays a major role in erectile dysfunction in middle-aged rats: Prevention by antioxidant therapy","volume":"10","author":"Silva","year":"2013","journal-title":"J Sex Med"},{"key":"2026041420271146800_bib34","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/j.urology.2009.05.098","article-title":"Upregulation of gp91phox subunit of NAD(P)H oxidase contributes to erectile dysfunction caused by long-term nitric oxide inhibition in rats: Reversion by regular physical training","volume":"75","author":"Claudino","year":"2010","journal-title":"Urology"},{"key":"2026041420271146800_bib35","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/sj.bjp.0706305","article-title":"Sildenafil citrate and sildenafil nitrate (NCX 911) are potent inhibitors of superoxide formation and gp91phox expression in porcine pulmonary artery endothelial cells","volume":"146","author":"Muzaffar","year":"2005","journal-title":"Br J Pharmacol"},{"key":"2026041420271146800_bib36","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1111\/j.1464-410X.2005.05643.x","article-title":"Sildenafil inhibits the formation of superoxide and the expression of gp47 NAD[P]H oxidase induced by the thromboxane A2 mimetic, U46619, in corpus cavernosal smooth muscle cells","volume":"96","author":"Koupparis","year":"2005","journal-title":"BJU Int"},{"key":"2026041420271146800_bib37","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.ejcts.2010.05.025","article-title":"Pre-conditioning with the soluble guanylate cyclase activator Cinaciguat reduces ischaemia-reperfusion injury after cardiopulmonary bypass","volume":"39","author":"Radovits","year":"2011","journal-title":"Eur J Cardiothorac Surg"},{"key":"2026041420271146800_bib38","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/978-3-540-68964-5_14","article-title":"NO and haem-independent soluble guanylyl cyclase activators","volume":"191","author":"Schmidt","year":"2009","journal-title":"Hand Exp Pharmacol"},{"key":"2026041420271146800_bib39","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1038\/sj.bjp.0704300","article-title":"Downregulation of vascular soluble guanylate cyclase induced by high salt intake in spontaneously hypertensive rats","volume":"134","author":"Kagota","year":"2001","journal-title":"Br J Pharmacol"},{"key":"2026041420271146800_bib40","doi-asserted-by":"crossref","first-page":"16671","DOI":"10.1073\/pnas.0405509101","article-title":"Reduced cGMP signaling associated with neointimal proliferation and vascular dysfunction in late-stage atherosclerosis","volume":"101","author":"Melichar","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026041420271146800_bib41","doi-asserted-by":"crossref","first-page":"L658","DOI":"10.1152\/ajplung.00189.2009","article-title":"The soluble guanylate cyclase activator HMR1766 reverses hypoxia-induced experimental pulmonary hypertension in mice","volume":"297","author":"Weissmann","year":"2009","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"2026041420271146800_bib42","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1152\/ajpheart.00953.2010","article-title":"Pulmonary and systemic vasodilator responses to the soluble guanylyl ciclase activator, BAY 60-2770, are not dependent on endogenous nitric oxide or reduced heme","volume":"300","author":"Pankey","year":"2011","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2026041420271146800_bib43","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.cardiores.2007.03.030","article-title":"Nitric oxide suppresses NADPH oxidase-dependent superoxide production by S-nitrosylation in human endothelial cells","volume":"75","author":"Selemidis","year":"2007","journal-title":"Cardiovasc Res"},{"key":"2026041420271146800_bib44","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1124\/jpet.107.124594","article-title":"Effects of 5-cyclopropyl-2-[1-(2-fluoro-benzyl)-1H-pyrazolo[3,4-b]pyridine-3-yl]pyrimidin-4-ylamine (BAY 41\u20132272) on smooth muscle tone, soluble guanylyl ciclase activity, and NADPH oxidase activity\/expression in corpus cavernosum from wild-type, neuronal, and endothelial nitric-oxide synthase null mice","volume":"322","author":"Teixeira","year":"2007","journal-title":"J Pharmacol Exp Ther"},{"key":"2026041420271146800_bib45","doi-asserted-by":"crossref","first-page":"C559","DOI":"10.1152\/ajpcell.00375.2012","article-title":"Protein kinase G increases antioxidant function in lung microvascular endothelial cells by inhibiting the c-Abl tyrosine kinase","volume":"306","author":"Stephens","year":"2014","journal-title":"Am J Physiol Cell Physiol"},{"key":"2026041420271146800_bib46","doi-asserted-by":"crossref","first-page":"L323","DOI":"10.1152\/ajplung.00442.2009","article-title":"cGMP increases antioxidant function and attenuates oxidant cell death in mouse lung microvascular endothelial cells by a protein kinase G-dependent mechanism","volume":"299","author":"Stephens","year":"2010","journal-title":"Am J Physiol Lung Cell Mol Physiol"}],"container-title":["The Journal of Sexual Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1743609515306032?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1743609515306032?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jsm\/article-pdf\/11\/11\/2661\/48360192\/jsm_11_11_2661.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jsm\/article-pdf\/11\/11\/2661\/48360192\/jsm_11_11_2661.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:53:10Z","timestamp":1776214390000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jsm\/article\/11\/11\/2661\/6958381"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,1]]},"references-count":46,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2014,11,1]]}},"URL":"https:\/\/doi.org\/10.1111\/jsm.12682","relation":{},"ISSN":["1743-6109","1743-6095"],"issn-type":[{"value":"1743-6109","type":"electronic"},{"value":"1743-6095","type":"print"}],"subject":[],"published-other":{"date-parts":[[2014,11]]},"published":{"date-parts":[[2014,11,1]]}}}