{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T17:30:23Z","timestamp":1781544623790,"version":"3.54.5"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,3,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Postorgasmic illness syndrome (POIS) is a rarely described syndrome characterized by transient flu-like symptoms and cognition disorders. Recent studies suggest that immunogenic reactivity to autologous semen is the underlying mechanism in POIS. However, there are no data published on immunoglobulin E (IgE)-mediated allergy to autologous semen in men without POIS.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Aim<\/jats:title>\n                  <jats:p>The purpose of the current work was to characterize the first diagnosed POIS patient in China and to study the allergic response of autologous semen in the affected patient and in three healthy males.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Specific IgE was tested with seminal fluid and common perennial aeroallergens in vitro. Skin prick tests and intracutaneous tests with autologous diluted semen were performed in the patient and three healthy donors. The pattern of IgE reactivity to patient's semen was identified using immunoblotting and ELISA.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main Outcome Measure<\/jats:title>\n                  <jats:p>Clinical features of POIS, skin reactions with autologous diluted seminal fluid, and the IgE reactivity patterns of immunoblotting and ELISA in vitro.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A patient was diagnosed with POIS. The patient complained of lifelong premature ejaculation symptoms and allergic rhinitis. Routine laboratory and hormonal assessments were generally within normal range. The patient had a positive skin test with his own semen. Three healthy donors also showed positive skin tests. No semen-specific IgE to autologous semen was detected in the serum of the affected patient or healthy males.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>This is the first report of a man with POIS in China. He had positive skin reactions after injection of autologous seminal fluid but no detectable serum concentrations of specific IgE antibodies. IgE-mediated semen allergy in men may not be the potential mechanism of POIS.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1111\/jsm.12813","type":"journal-article","created":{"date-parts":[[2015,1,29]],"date-time":"2015-01-29T11:04:00Z","timestamp":1422529440000},"page":"840-845","source":"Crossref","is-referenced-by-count":38,"title":["Postorgasmic Illness Syndrome (POIS) in a Chinese Man: No Proof for IgE-Mediated Allergy to Semen"],"prefix":"10.1093","volume":"12","author":[{"given":"Nannan","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Allergy , Beijing, \u00a0 China"},{"name":"Peking Union Medical College Hospital , Beijing, \u00a0 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangpeng","family":"Xi","sequence":"additional","affiliation":[{"name":"Department of Allergy , Beijing, \u00a0 China"},{"name":"Peking Union Medical College Hospital , Beijing, \u00a0 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Urology Surgery , Beijing, \u00a0 China"},{"name":"Peking Union Medical College Hospital , Beijing, \u00a0 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Allergy , Beijing, \u00a0 China"},{"name":"Peking Union Medical College Hospital , Beijing, \u00a0 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,3,1]]},"reference":[{"key":"2023010709211119400_bb0010","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1080\/009262302760328280","article-title":"Postorgasmic illness syndrome: Two cases","volume":"28","author":"Waldinger","year":"2002","journal-title":"J Sex Marital Ther"},{"key":"2023010709211119400_bb0015","first-page":"220","article-title":"A clinical case of suspected postorgasmic illness syndrome","volume":"10","author":"Shigeta","year":"2013","journal-title":"J Sex Med"},{"key":"2023010709211119400_bb0020","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1111\/j.1743-6109.2010.01707.x","article-title":"Postorgasm illness syndrome-a spectrum of illnesses","volume":"7","author":"Ashby","year":"2010","journal-title":"J Sex Med"},{"key":"2023010709211119400_bb0025","doi-asserted-by":"crossref","first-page":"113","DOI":"10.12688\/f1000research.2-113.v1","article-title":"Post-orgasmic illness syndrome: A case report","volume":"2","author":"Attia","year":"2013","journal-title":"F1000 Research"},{"key":"2023010709211119400_bb0030","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1111\/j.1743-6109.2010.02166.x","article-title":"Postorgasmic illness syndrome (POIS) in 45 dutch Caucasian males: Clinical characteristics and evidence for an immunogenic pathogenesis (part 1)","volume":"8","author":"Waldinger","year":"2011","journal-title":"J Sex Med"},{"key":"2023010709211119400_bb0035","doi-asserted-by":"crossref","DOI":"10.1136\/bcr.10.2009.2359","article-title":"Benign coital headache relieved by partner's pregnancies with implications for future treatment","volume":"2010","author":"Dexter","year":"2010","journal-title":"BMJ Case Rep"},{"key":"2023010709211119400_bb0040","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1111\/j.1743-6109.2010.02167.x","article-title":"Hyposensitization therapy with autologous semen in two dutch Caucasian males: Beneficial effects in postorgasmic illness syndrome (POIS; 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