{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T00:49:36Z","timestamp":1771980576855,"version":"3.50.1"},"reference-count":54,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>The prevalence of erectile dysfunction (ED) and its correlates in men with acromegaly has never been investigated.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Aim<\/jats:title>\n                  <jats:p>The aim of this study was to evaluate sexual function in men with acromegaly.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Multicenter-based, retrospective analysis of a nonselected series of 57 acromegalic subjects (mean age: 52.7\u2009\u00b1\u200914.2 years) was performed. Acromegalic subjects reporting ED (n\u2009=\u200924) were compared with matched ED patients without acromegaly or pituitary disease (controls), selected from a cohort of more than 4,000 subjects enrolled in the Florence Sexual Medicine and Andrology Unit.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main Outcome Measures<\/jats:title>\n                  <jats:p>Patients were interviewed using Structured Interview on Erectile Dysfunction (SIEDY) structured interview, a 13-item tool for the assessment of ED-related morbidities. Several clinical and biochemical parameters were taken. Penile color Doppler ultrasound (PCDU) was performed in a subgroup of 37 acromegalic subjects.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>ED was reported by 42.1% of acromegalic subjects. After adjusting for age and testosterone, acromegalic subjects with ED had a higher prevalence of hypertension and more often reported an impairment of sleep-related erections and a longer smoking habit. Accordingly, acromegaly-associated ED was characterized by a higher organic component and worse PCDU parameters. No relationship between ED and testosterone levels or other acromegaly-related parameters was found. However, acromegalic subjects with severe ED reported a longer disease duration. In a case-control analysis, comparing acromegalic subjects with ED-matched controls free from acromegaly (1:5 ratio), acromegalic men had a worse ED problem and a higher organic component of ED, as derived from SIEDY score. In line with these data, acromegalic patients with ED had a higher prevalence of major adverse cardiovascular events history at enrollment and lower PCDU parameters.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Subjects with complicated acromegaly are at an increased risk of developing ED, especially those with cardiovascular morbidities. Our data suggest including a sexual function evaluation in routine acromegaly follow-up.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1111\/jsm.12859","type":"journal-article","created":{"date-parts":[[2015,3,4]],"date-time":"2015-03-04T09:04:47Z","timestamp":1425459887000},"page":"1184-1193","source":"Crossref","is-referenced-by-count":28,"title":["Erectile Dysfunction Is Common among Men with Acromegaly and Is Associated with Morbidities Related to the Disease"],"prefix":"10.1093","volume":"12","author":[{"given":"Francesco","family":"Lotti","sequence":"first","affiliation":[{"name":"Sexual Medicine and Andrology Unit , Florence, \u00a0 Italy"},{"name":"Department of Experimental and Clinical Biomedical Sciences \u201cMario Serio\u201d , Florence, \u00a0 Italy"},{"name":"University of Florence , Florence, \u00a0 Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenzo","family":"Rochira","sequence":"additional","affiliation":[{"name":"Unit of Endocrinology , Modena, \u00a0 Italy"},{"name":"Department of Biomedical, Metabolic and Neural Sciences , Modena, \u00a0 Italy"},{"name":"University of Modena and Reggio Emilia , Modena, \u00a0 Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosario","family":"Pivonello","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina Clinica e Chirurgia , Naples, \u00a0 Italy"},{"name":"Sezione di Endocrinologia , Naples, \u00a0 Italy"},{"name":"Universit\u00e0 Federico II di Napoli , Naples, \u00a0 Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniele","family":"Santi","sequence":"additional","affiliation":[{"name":"Unit of Endocrinology , Modena, \u00a0 Italy"},{"name":"Department of Biomedical, Metabolic and Neural Sciences , Modena, \u00a0 Italy"},{"name":"University of Modena and Reggio Emilia , Modena, \u00a0 Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariano","family":"Galdiero","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina Clinica e Chirurgia , Naples, \u00a0 Italy"},{"name":"Sezione di Endocrinologia , Naples, \u00a0 Italy"},{"name":"Universit\u00e0 Federico II di Napoli , Naples, \u00a0 Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa","family":"Maseroli","sequence":"additional","affiliation":[{"name":"Sexual Medicine and Andrology Unit , Florence, \u00a0 Italy"},{"name":"Department of Experimental and Clinical Biomedical Sciences \u201cMario Serio\u201d , Florence, \u00a0 Italy"},{"name":"University of Florence , Florence, \u00a0 Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Balestrieri","sequence":"additional","affiliation":[{"name":"Unit of Endocrinology and Diabetology , Cesena, \u00a0 Italy"},{"name":"Department of Internal Medicine , Cesena, \u00a0 Italy"},{"name":"Ospedale M. 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