{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T21:46:10Z","timestamp":1789076770620,"version":"build-2803163510"},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund (FWF)","doi-asserted-by":"crossref","award":["P22838-B13"],"award-info":[{"award-number":["P22838-B13"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003042","name":"Else Kr\u00f6ner-Fresenius-Stiftung","doi-asserted-by":"crossref","award":["P64\/08\/A76\/08"],"award-info":[{"award-number":["P64\/08\/A76\/08"]}],"id":[{"id":"10.13039\/501100003042","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Men and postmenopausal women exhibit a higher risk for atherosclerosis than premenopausal women. These differences were often attributed to sex steroids, but the role of estrogen and testosterone in atherosclerosis are more complex than anticipated. Cross-sex hormone therapy of transsexuals is an interesting model, which has been used to study hormonal effects on serum lipid profile, insulin resistance, and body composition. However, studies on macrophage cholesterol efflux, the first step in reverse cholesterol transport, are not available.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Aim<\/jats:title>\n                  <jats:p>The aim of this study was to evaluate the effect of cross-sex hormone therapy in transsexuals on the capacity of serum to accept cholesterol from macrophages.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Cholesterol acceptor capacity (CAC) of serum from transsexuals before and after at least 6 months of hormone treatment was measured using macrophage tissue culture models.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main Outcome Measures<\/jats:title>\n                  <jats:p>CAC of serum using the human acute monocytic leukemia cell line (THP-1 cells).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Unexpectedly, the CAC of serum from male to female (MtF) transsexuals was not increased, but decreased after hormone therapy. Serum from female to male (FtM) transsexuals showed no changes in CAC.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Despite drastic changes in hormone status, no increase in CAC was detected in MtF patients, and no alteration in CAC was seen in FtM patients. These data further challenge the traditional view that estrogen and testosterone exert beneficial and detrimental effects, respectively, on lipoprotein metabolism and ultimately atherosclerosis.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1111\/jsm.12878","type":"journal-article","created":{"date-parts":[[2015,4,9]],"date-time":"2015-04-09T01:56:05Z","timestamp":1428544565000},"page":"1436-1439","source":"Crossref","is-referenced-by-count":6,"title":["Profound Changes in Sex Hormone Levels during Cross-Sex Hormone Therapy of Transsexuals do not Alter Serum Cholesterol Acceptor Capacity"],"prefix":"10.1093","volume":"12","author":[{"given":"Anna","family":"Wultsch","sequence":"first","affiliation":[{"name":"Department of Medical Chemistry , Vienna, \u00a0 Austria"},{"name":"Medical University of Vienna , Vienna, \u00a0 Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrike","family":"Kaufmann","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology , Vienna, \u00a0 Austria"},{"name":"Medical University of Vienna , Vienna, \u00a0 Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Ott","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology , Vienna, \u00a0 Austria"},{"name":"Medical University of Vienna , Vienna, \u00a0 Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatjana","family":"Stojakovic","sequence":"additional","affiliation":[{"name":"Clinical Institute of Medical and Chemical Laboratory Diagnostics , Graz, \u00a0 Austria"},{"name":"Medical University of Graz , Graz, \u00a0 Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hubert","family":"Scharnagl","sequence":"additional","affiliation":[{"name":"Clinical Institute of Medical and Chemical Laboratory Diagnostics , Graz, \u00a0 Austria"},{"name":"Medical University of Graz , Graz, \u00a0 Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herbert","family":"Stangl","sequence":"additional","affiliation":[{"name":"Department of Medical Chemistry , Vienna, \u00a0 Austria"},{"name":"Medical University of Vienna , Vienna, \u00a0 Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Witta Monika","family":"Strobl","sequence":"additional","affiliation":[{"name":"Department of Medical Chemistry , Vienna, \u00a0 Austria"},{"name":"Medical University of Vienna , Vienna, \u00a0 Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,6,1]]},"reference":[{"key":"2023012309055399000_bb0010","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1126\/science.1112062","article-title":"Molecular and cellular basis of cardiovascular gender differences","volume":"308","author":"Mendelsohn","year":"2005","journal-title":"Science"},{"key":"2023012309055399000_bb0015","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1210\/er.2003-0005","article-title":"Androgens and cardiovascular disease","volume":"24","author":"Liu","year":"2003","journal-title":"Endocr Rev"},{"key":"2023012309055399000_bb0020","article-title":"Testosterone supplementation and cardiovascular risk","author":"Corona","year":"2014","journal-title":"Trends Cardiovasc Med"},{"key":"2023012309055399000_bb0025","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1056\/NEJMoa1001689","article-title":"Cholesterol efflux capacity, high-density lipoprotein function, and atherosclerosis","volume":"364","author":"Khera","year":"2011","journal-title":"N Engl J Med"},{"key":"2023012309055399000_bb0030","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1194\/jlr.M700510-JLR200","article-title":"Cellular SR-BI and ABCA1-mediated cholesterol efflux are gender-specific in healthy subjects","volume":"49","author":"Catalano","year":"2008","journal-title":"J Lipid Res"},{"key":"2023012309055399000_bb0035","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1530\/EJE-10-1038","article-title":"A long-term follow-up study of mortality in transsexuals receiving treatment with cross-sex hormones","volume":"164","author":"Asscheman","year":"2011","journal-title":"Eur J Endocrinol"},{"key":"2023012309055399000_bb0040","doi-asserted-by":"crossref","first-page":"2361","DOI":"10.1111\/j.1743-6109.2011.02311.x","article-title":"Cross-sex hormone therapy alters the serum lipid profile: A retrospective cohort study in 169 transsexuals","volume":"8","author":"Ott","year":"2011","journal-title":"J Sex Med"},{"key":"2023012309055399000_bb0045","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.jsbmb.2009.04.008","article-title":"Human macrophage cholesterol efflux potential is enhanced by HDL-associated 17beta-estradiol fatty acyl esters","volume":"116","author":"Badeau","year":"2009","journal-title":"J Steroid Biochem Mol Biol"},{"key":"2023012309055399000_bb0050","doi-asserted-by":"crossref","first-page":"701","DOI":"10.3109\/09513590.2010.507826","article-title":"Increased leukocyte ABCA1 gene expression in post-menopausal women on hormone replacement therapy","volume":"27","author":"Darabi","year":"2011","journal-title":"Gynecol Endocrinol"},{"key":"2023012309055399000_bb0055","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1210\/jc.2010-2061","article-title":"Sex differences in lipid and lipoprotein metabolism: It's not just about sex hormones","volume":"96","author":"Wang","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"2023012309055399000_bb0060","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-2265.2009.03632.x","article-title":"Effect of sex steroid use on cardiovascular risk in transsexual individuals: A systematic review and meta-analyses","volume":"72","author":"Elamin","year":"2010","journal-title":"Clin Endocrinol (Oxf)"}],"container-title":["The Journal of Sexual Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1743609515310468?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1743609515310468?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jsm\/article-pdf\/12\/6\/1436\/48586267\/jsm_12_6_1436.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jsm\/article-pdf\/12\/6\/1436\/48586267\/jsm_12_6_1436.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,9]],"date-time":"2023-02-09T14:42:39Z","timestamp":1675953759000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jsm\/article\/12\/6\/1436\/6980124"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,1]]},"references-count":11,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2015,6,1]]},"published-print":{"date-parts":[[2015,6,1]]}},"URL":"https:\/\/doi.org\/10.1111\/jsm.12878","relation":{},"ISSN":["1743-6109","1743-6095"],"issn-type":[{"value":"1743-6109","type":"electronic"},{"value":"1743-6095","type":"print"}],"subject":[],"published-other":{"date-parts":[[2015,6]]},"published":{"date-parts":[[2015,6,1]]}}}