{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T16:58:36Z","timestamp":1790096316412,"version":"4.0.1"},"reference-count":9,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"MEC Espa\u00f1a","award":["PSI2010-15115"],"award-info":[{"award-number":["PSI2010-15115"]}]},{"name":"MEC Espa\u00f1a","award":["PSI2011-24496"],"award-info":[{"award-number":["PSI2011-24496"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,6,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>The A2 allele of the CYP17\u2005MspA1 polymorphism has been linked to higher levels of serum testosterone, progesterone, and estradiol.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Aim<\/jats:title>\n                  <jats:p>To determine whether the CYP17\u2005MspA1 polymorphism is associated with transsexualism.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We analyzed 151 male-to-female (MtF), 142 female-to-male (FtM), 167 control male, and 168 control female individuals. Fragments that included the mutation were amplified by PCR and digested with MspA1. Our data were compared with the allele\/genotype frequencies provided by the 1000 Genomes Data Base, and contrasted with a MEDLINE search of the CYP17\u2005MspA1 polymorphism in the literature.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main Outcome Measures<\/jats:title>\n                  <jats:p>We investigated the association between transsexualism and the CYP17\u2005MspA1 polymorphism.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A2 frequency was higher in the FtM (0.45) than the female control (0.38) and male control (0.39) groups, or the MtF group (0.36). This FtM\u2009&amp;gt;\u2009MtF pattern reached statistical significance (P\u2009=\u20090.041), although allele frequencies were not gender specific in the general population (P\u2009=\u20090.887). This observation concurred with the 1000 Genomes Data Base and the MEDLINE search.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Our data confirm a sex-dependent allele distribution of the CYP17\u2005MspA1 polymorphism in the transsexual population, FtM\u2009&amp;gt;\u2009MtF, suggestive of a hypothetical A2 involvement in transsexualism since the allele frequencies in the general population seem to be clearly related to geographic origin and ethnic background, but not sex.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1111\/jsm.12895","type":"journal-article","created":{"date-parts":[[2015,4,29]],"date-time":"2015-04-29T07:21:36Z","timestamp":1430292096000},"page":"1329-1333","source":"Crossref","is-referenced-by-count":30,"title":["The <i>CYP17\u2005Msp<\/i>A1 Polymorphism and the Gender 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