{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T01:54:29Z","timestamp":1791338069484,"version":"4.3.1"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2015,11,1]],"date-time":"2015-11-01T00:00:00Z","timestamp":1446336000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Korean Health Technology R&D Project","award":["HI14C0018"],"award-info":[{"award-number":["HI14C0018"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Ejaculation dysfunction is one of the most common male sexual disorders. Despite its prevalence and adverse impact on patients, little attention has been given to investigating ejaculation dysfunction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>We introduce a new method for evaluating ejaculation dysfunction in rats with a telemetric device.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A pressure transducer was surgically implanted in the seminal vesicles of 7-week-old male Sprague\u2013Dawley rats. One week later, the rats were subcutaneously administered tamsulosin 3 \u03bcg\/kg, and intra-seminal vesicle pressure (ISVP) was recorded in freely moving rats after an injection of apomorphine (80 \u03bcg\/kg). Same rats repeated experiment with tamsulosin 10 \u03bcg\/kg, silodosin 1 mg\/kg, and normal saline with 3-day intervals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome Measure<\/jats:title><jats:p>Sexual events were visually identified and recorded. Ejaculation was confirmed by visualization of a copulatory plug in the tip of the penis. We compared the maximal ISVP and area under the curve (AUC) of the ISVP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Adequate ISVP data were easily recorded and available in 66.6% rats (10\/15) over a 6-week telemetric recording period (12 recordings). The mean number of ejaculations during an inspection time of 30 minutes was 1.5 \u00b1 0.1. The maximal ISVP values in rats receiving 3 \u03bcg\/kg (30.0 \u00b1 5.2\u2009mm Hg) and 10 \u03bcg\/kg tamsulosin (15.1 \u00b1 1.6\u2009mm Hg) and 1 mg\/kg silodosin (12.9 \u00b1 2.2\u2009mm Hg) were significantly lower than that in control rats (61.4 \u00b1 13.4\u2009mm Hg, P &amp;lt; 0.05). The AUC values in rats receiving 3 \u03bcg\/kg (72.7 \u00b1 18.9\u2009mm Hg \u00d7 s) and 10 \u03bcg\/kg tamsulosin (23.5 \u00b1 6.1\u2009mm Hg) and 1 mg\/kg silodosin (23.9 \u00b1 8.0\u2009mm Hg) were also lower than that of control rats (162.6 \u00b1 34.3\u2009mm Hg, P &amp;lt; 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Telemetric ISVP assessment is reliable and feasible for investigating apomorphine-induced ejaculation in rats. Tamsulosin (3 \u03bcg\/kg and 10 \u03bcg\/kg) and silodosin 1 mg\/kg decreased the ISVP during ejaculation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jsm.13025","type":"journal-article","created":{"date-parts":[[2015,10,27]],"date-time":"2015-10-27T04:41:29Z","timestamp":1445920889000},"page":"2134-2140","source":"Crossref","is-referenced-by-count":2,"title":["New Methodology for Investigating Ejaculation Dysfunction: Measuring Intraluminal Seminal Vesicle Pressure in Rats with a Telemetric Device"],"prefix":"10.1093","volume":"12","author":[{"given":"Hyun Hwan","family":"Sung","sequence":"first","affiliation":[{"name":"The Department of Urology \u00a0 \u00a0 \u00a0 , Seoul , Korea"},{"name":"Samsung Medical Center \u00a0 \u00a0 \u00a0 , Seoul , Korea"},{"name":"Samsung Biomedical Research Institute \u00a0 \u00a0 \u00a0 , Seoul , Korea"},{"name":"Sungkyunkwan University School of Medicine \u00a0 \u00a0 \u00a0 , Seoul , Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Jun","family":"Kim","sequence":"additional","affiliation":[{"name":"The Department of Urology \u00a0 \u00a0 \u00a0 , Seoul , Korea"},{"name":"Samsung Medical Center \u00a0 \u00a0 \u00a0 , Seoul , Korea"},{"name":"Samsung Biomedical Research Institute \u00a0 \u00a0 \u00a0 , Seoul , Korea"},{"name":"Sungkyunkwan University School of Medicine \u00a0 \u00a0 \u00a0 , Seoul , Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deok Hyun","family":"Han","sequence":"additional","affiliation":[{"name":"The Department of Urology \u00a0 \u00a0 \u00a0 , Seoul , Korea"},{"name":"Samsung Medical Center \u00a0 \u00a0 \u00a0 , Seoul , Korea"},{"name":"Samsung Biomedical Research Institute \u00a0 \u00a0 \u00a0 , Seoul , Korea"},{"name":"Sungkyunkwan University School of Medicine \u00a0 \u00a0 \u00a0 , Seoul , Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su Jeong","family":"Kang","sequence":"additional","affiliation":[{"name":"The Department of Urology \u00a0 \u00a0 \u00a0 , Seoul , Korea"},{"name":"Samsung Medical Center \u00a0 \u00a0 \u00a0 , Seoul , Korea"},{"name":"Samsung Biomedical Research Institute \u00a0 \u00a0 \u00a0 , Seoul , Korea"},{"name":"Sungkyunkwan University School of Medicine \u00a0 \u00a0 \u00a0 , Seoul , Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mee Ree","family":"Chae","sequence":"additional","affiliation":[{"name":"The Department of Urology \u00a0 \u00a0 \u00a0 , Seoul , Korea"},{"name":"Samsung Medical Center \u00a0 \u00a0 \u00a0 , Seoul , Korea"},{"name":"Samsung Biomedical Research Institute \u00a0 \u00a0 \u00a0 , Seoul , Korea"},{"name":"Sungkyunkwan University School of Medicine \u00a0 \u00a0 \u00a0 , Seoul , Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chul Young","family":"Kim","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Institute of Pharmaceutical Science and Technology \u00a0 , Ansan , Korea"},{"name":"Hanyang University \u00a0 , Ansan , Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Kwan","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Urology, Medical School, and Institute for Medical Sciences \u00a0 , Jeonju , Korea"},{"name":"Chonbuk National University \u00a0 , Jeonju , Korea"},{"name":"Research Institute and Clinical Trial Center of Medical Device \u00a0 , Jeonju , Korea"},{"name":"Chonbuk National University Hospital \u00a0 , Jeonju , Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Won","family":"Lee","sequence":"additional","affiliation":[{"name":"The Department of Urology \u00a0 \u00a0 \u00a0 , Seoul , Korea"},{"name":"Samsung Medical Center \u00a0 \u00a0 \u00a0 , Seoul , Korea"},{"name":"Samsung Biomedical Research Institute \u00a0 \u00a0 \u00a0 , Seoul , Korea"},{"name":"Sungkyunkwan University School of 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