{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T14:40:09Z","timestamp":1791384009853,"version":"4.3.3"},"reference-count":53,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,3,18]],"date-time":"2013-03-18T00:00:00Z","timestamp":1363564800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"EU-NN"},{"name":"UCB-Pharma SA"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Sleep Research"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The aim of this study was to describe the clinical and <jats:styled-content style=\"fixed-case\">PSG<\/jats:styled-content> characteristics of narcolepsy with cataplexy and their genetic predisposition by using the retrospective patient database of the European Narcolepsy Network (<jats:styled-content style=\"fixed-case\">EU<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">NN<\/jats:styled-content>). We have analysed retrospective data of 1099 patients with narcolepsy diagnosed according to International Classification of Sleep Disorders\u20102. Demographic and clinical characteristics, polysomnography and multiple sleep latency test data, hypocretin\u20101 levels, and genome\u2010wide genotypes were available. We found a significantly lower age at sleepiness onset (men versus women: 23.74\u00a0\u00b1\u00a012.43 versus 21.49\u00a0\u00b1\u00a011.83, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.003) and longer diagnostic delay in women (men versus women: 13.82\u00a0\u00b1\u00a013.79 versus 15.62\u00a0\u00b1\u00a014.94, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.044). The mean diagnostic delay was 14.63\u00a0\u00b1\u00a014.31\u00a0years, and longer delay was associated with higher body mass index. The best predictors of short diagnostic delay were young age at diagnosis, cataplexy as the first symptom and higher frequency of cataplexy attacks. The mean multiple sleep latency negatively correlated with Epworth Sleepiness Scale (<jats:styled-content style=\"fixed-case\">ESS<\/jats:styled-content>) and with the number of sleep\u2010onset rapid eye movement periods (<jats:styled-content style=\"fixed-case\">SOREMP<\/jats:styled-content>s), but none of the polysomnographic variables was associated with subjective or objective measures of sleepiness. Variant rs2859998 in <jats:styled-content style=\"fixed-case\">UBXN<\/jats:styled-content>2B gene showed a strong association (<jats:italic>P<\/jats:italic>\u00a0=\u00a01.28E\u201007) with the age at onset of excessive daytime sleepiness, and rs12425451 near the transcription factor <jats:styled-content style=\"fixed-case\">TEAD<\/jats:styled-content>4 (<jats:italic>P<\/jats:italic>\u00a0=\u00a01.97E\u201007) with the age at onset of cataplexy. Altogether, our results indicate that the diagnostic delay remains extremely long, age and gender substantially affect symptoms, and that a genetic predisposition affects the age at onset of symptoms.<\/jats:p>","DOI":"10.1111\/jsr.12044","type":"journal-article","created":{"date-parts":[[2013,3,18]],"date-time":"2013-03-18T00:59:31Z","timestamp":1363568371000},"page":"482-495","source":"Crossref","is-referenced-by-count":208,"title":["Clinical, polysomnographic and genome\u2010wide association analyses of narcolepsy with cataplexy: a European Narcolepsy Network study"],"prefix":"10.1111","volume":"22","author":[{"given":"Gianina","family":"Luca","sequence":"first","affiliation":[{"name":"Center for Integrative Genomics (CIG) University of Lausanne Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Haba\u2010Rubio","sequence":"additional","affiliation":[{"name":"Center for Investigation and Research in Sleep (CIRS) Centre 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