{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T13:57:12Z","timestamp":1761400632775},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,8,29]],"date-time":"2013-08-29T00:00:00Z","timestamp":1377734400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Bologna University RFO funds"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Sleep Research"],"published-print":{"date-parts":[[2014,2]]},"abstract":"Summary<\/jats:title>Narcolepsy with cataplexy (NC<\/jats:styled-content>) is a lifelong disorder caused by loss of hypothalamic hypocretin\/orexin (HCRT<\/jats:styled-content>) neurones, often starting in childhood. NC<\/jats:styled-content> patients show altered control of heart rate (HR<\/jats:styled-content>) and a normotensive non\u2010dipper blood pressure (BP<\/jats:styled-content>) profile, but the natural history and prognostic significance of these alterations remain unclear. Similar alterations have been observed in HCRT<\/jats:styled-content>\u2010ataxin\u20103 transgenic (TG<\/jats:styled-content>) NC<\/jats:styled-content> mice lacking HCRT<\/jats:styled-content> neurones, but studies have been limited to young adult individuals <4\u00a0months of age. Here we evaluated long\u2010term effects of NC<\/jats:styled-content> on derangements in the wake\u2013sleep state and cardiovascular control by studying middle\u2010aged TG<\/jats:styled-content>. We chronically instrumented TG<\/jats:styled-content> and wild\u2010type mice aged 10\u201311\u00a0months with electrodes for sleep scoring and a telemetric transducer for BP<\/jats:styled-content> and HR<\/jats:styled-content> measurements. We then recorded mice in freely behaving conditions. TG<\/jats:styled-content> showed a NC<\/jats:styled-content> phenotype including fragmentation of wakefulness, reduced latency to rapid eye movement sleep (REMS<\/jats:styled-content>) and cataplexy\u2010like events. TG<\/jats:styled-content> also showed blunted BP<\/jats:styled-content> decline on entering non\u2010rapid eye movement sleep (NREMS<\/jats:styled-content>), enhanced BP<\/jats:styled-content> increase on passing to REMS<\/jats:styled-content>, increased HR<\/jats:styled-content>, and blunted changes in HR<\/jats:styled-content> upon arousal and awakening from NREMS<\/jats:styled-content>. Histological and ultrastructural analysis of cardiovascular and renal tissue did not reveal evidence of subclinical hypertensive organ damage. These data indicate that HCRT<\/jats:styled-content> neurone loss in TG<\/jats:styled-content> causes alterations in wake\u2013sleep behaviour and cardiovascular control that are not peculiar to the beginning of the disease but are maintained at least up to middle age. These alterations are similar to those in adult NC<\/jats:styled-content> patients, but do not produce early subclinical damage to the heart and kidneys.<\/jats:p>","DOI":"10.1111\/jsr.12081","type":"journal-article","created":{"date-parts":[[2013,8,29]],"date-time":"2013-08-29T12:42:40Z","timestamp":1377780160000},"page":"98-106","source":"Crossref","is-referenced-by-count":28,"title":["Sleep and cardiovascular phenotype in middle\u2010aged hypocretin\u2010deficient narcoleptic mice"],"prefix":"10.1111","volume":"23","author":[{"given":"Alessandro","family":"Silvani","sequence":"first","affiliation":[{"name":"PRISM Laboratory Department of Biomedical and Neuromotor Sciences Alma Mater Studiorum Universit\u00e0 di Bologna Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Bastianini","sequence":"additional","affiliation":[{"name":"PRISM Laboratory Department of Biomedical and Neuromotor Sciences Alma Mater Studiorum Universit\u00e0 di Bologna Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Berteotti","sequence":"additional","affiliation":[{"name":"PRISM Laboratory Department of Biomedical and Neuromotor Sciences Alma Mater Studiorum Universit\u00e0 di Bologna Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanna","family":"Cenacchi","sequence":"additional","affiliation":[{"name":"Pathology Unit Department of Biomedical and Neuromotor Sciences Alma Mater Studiorum Universit\u00e0 di Bologna Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ornella","family":"Leone","sequence":"additional","affiliation":[{"name":"Pathology Unit S. Orsola\u2010Malpighi Hospital Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viviana","family":"Lo Martire","sequence":"additional","affiliation":[{"name":"PRISM Laboratory Department of Biomedical and Neuromotor Sciences Alma Mater Studiorum Universit\u00e0 di Bologna Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Papa","sequence":"additional","affiliation":[{"name":"Pathology Unit Department of Biomedical and Neuromotor Sciences Alma Mater Studiorum Universit\u00e0 di Bologna Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanna","family":"Zoccoli","sequence":"additional","affiliation":[{"name":"PRISM Laboratory Department of Biomedical and Neuromotor Sciences Alma Mater Studiorum Universit\u00e0 di Bologna Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,8,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/34.2.213"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2869.2011.00945.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.107.087262"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2010.01.048"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/34.2.219"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0038977"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-012369454-6\/50074-1"},{"key":"e_1_2_8_9_1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.5665\/sleep.2286","article-title":"Autonomic alterations in narcolepsy\u2010contrasting results in mice and men","volume":"36","author":"Fronczek R.","year":"2013","journal-title":"Sleep"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2010.01.028"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.1738"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.108.113191"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00293-8"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.04.043"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3109\/07420528.2012.701127"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(03)03002-6"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00263.2012"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.hjh.0000254377.18983.eb"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0047032"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.5665\/sleep\/32.1.111"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.108.125542"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2011.04.003"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00668.2011"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsr.12007"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.2308"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(02)00953-9"}],"container-title":["Journal of Sleep Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjsr.12081","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjsr.12081","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jsr.12081","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T21:36:02Z","timestamp":1696282562000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jsr.12081"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8,29]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["10.1111\/jsr.12081"],"URL":"https:\/\/doi.org\/10.1111\/jsr.12081","archive":["Portico"],"relation":{},"ISSN":["0962-1105","1365-2869"],"issn-type":[{"value":"0962-1105","type":"print"},{"value":"1365-2869","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8,29]]}}}