{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T04:22:29Z","timestamp":1778127749302,"version":"3.51.4"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,11,26]],"date-time":"2013-11-26T00:00:00Z","timestamp":1385424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Bologna University","award":["RFO 2008-11"],"award-info":[{"award-number":["RFO 2008-11"]}]},{"name":"Ministry of Instruction, University and Research, Italy","award":["PRIN 2008"],"award-info":[{"award-number":["PRIN 2008"]}]},{"name":"Ministry of Instruction, University and Research, Italy","award":["prot.2008FY7K9S"],"award-info":[{"award-number":["prot.2008FY7K9S"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Sleep Research"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Hypocretin\/orexin peptides are known for their role in the control of the wake\u2013sleep cycle and narcolepsy\u2013cataplexy pathophysiology. Recent studies suggested that hypocretin peptides also have a role in pregnancy. We tested this hypothesis by conducting a retrospective analysis on pregnancy complications in two different mouse models of hypocretin deficiency. We recorded 85 pregnancies of mice lacking either hypocretin peptides (knockout) or hypocretin\u2010releasing neurons (transgenic) and their wild\u2010type controls. Pregnancy was associated with unexplained dam death before delivery in 3\/15 pregnancies in knockout mice, and in 3\/23 pregnancies in transgenic mice. No casualties occurred in wild\u2010type pregnant dams (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.007 versus hypocretin\u2010deficient mice as a whole). Hypocretin deficiency did not impact either on litter size or the number of weaned pups per litter. These data provide preliminary evidence of a critical role of hypocretin deficiency in pregnancy.<\/jats:p>","DOI":"10.1111\/jsr.12107","type":"journal-article","created":{"date-parts":[[2013,11,26]],"date-time":"2013-11-26T06:51:24Z","timestamp":1385448684000},"page":"186-188","source":"Crossref","is-referenced-by-count":8,"title":["A critical role of hypocretin deficiency in pregnancy"],"prefix":"10.1111","volume":"23","author":[{"given":"Stefano","family":"Bastianini","sequence":"first","affiliation":[{"name":"PRISM Lab Department of Biomedical and Neuromotor Sciences Alma Mater Studiorum Universit\u00e0 di Bologna Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Berteotti","sequence":"additional","affiliation":[{"name":"PRISM Lab Department of Biomedical and Neuromotor Sciences Alma Mater Studiorum Universit\u00e0 di Bologna Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viviana","family":"Lo Martire","sequence":"additional","affiliation":[{"name":"PRISM Lab Department of Biomedical and Neuromotor Sciences Alma Mater Studiorum Universit\u00e0 di Bologna Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Silvani","sequence":"additional","affiliation":[{"name":"PRISM Lab Department of Biomedical and Neuromotor Sciences Alma Mater Studiorum Universit\u00e0 di Bologna Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanna","family":"Zoccoli","sequence":"additional","affiliation":[{"name":"PRISM Lab Department of Biomedical and Neuromotor Sciences Alma Mater Studiorum Universit\u00e0 di Bologna Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,11,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/34.2.213"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/07420528.2011.635231"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81973-X"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00293-8"},{"key":"e_1_2_8_6_1","first-page":"601","article-title":"Conception, pregnancy, delivery and breastfeeding in a narcoleptic patient with cataplexy","volume":"4","author":"Hoque R.","year":"2008","journal-title":"J. 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