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In this case\u2013control study, 11 patients with narcolepsy with cataplexy and 11 healthy adults underwent an oral glucose tolerance test, and dexamethasone suppression\/corticotropin\u2010releasing hormone stimulation test. The average age of patients and controls was 35.1\u00a0\u00b1\u00a013.2 and 41.0\u00a0\u00b1\u00a02.9\u00a0years, respectively, body mass index was 28.1\u00a0\u00b1\u00a06.6 and 25.5\u00a0\u00b1\u00a04.7\u00a0kg\u00a0m<jats:sup>\u22122<\/jats:sup>. We did not find evidence of a significantly increased prevalence of disturbed glucose tolerance in patients with narcolepsy. After hypothalamo\u2013pituitary\u2013adrenal axis suppression, the number of non\u2010suppressors did not differ between the groups, indicating normal negative feedback sensitivity. The level of cortisol after dexamethasone suppression was significantly lower in patients with narcolepsy, suggesting a slight basal downregulation and\/or a slightly increased negative feedback sensitivity of the major endocrine stress system in narcolepsy. Following corticotropin\u2010releasing hormone stimulation, there were no significant differences in levels of adrenocorticotropic hormone or cortisol, and in adrenocortical responsivity to adrenocorticotropic hormone. Finally, patients with narcolepsy displayed significantly higher plasma levels of tumour necrosis factor alpha, soluble tumour necrosis factor receptor p55, soluble tumour necrosis factor receptor p75 and interleukin 6 after adjustment for body mass index. The present study confirms that narcolepsy by itself is not associated with disturbances of glucose metabolism, but goes along with a subtle dysregulation of inflammatory cytokine production. We also found that dynamic hypothalamo\u2013pituitary\u2013adrenal system response is not altered, whereas negative feedback to dexamethasone might be slightly enhanced.<\/jats:p>","DOI":"10.1111\/jsr.12138","type":"journal-article","created":{"date-parts":[[2014,3,20]],"date-time":"2014-03-20T11:04:30Z","timestamp":1395313470000},"page":"425-431","source":"Crossref","is-referenced-by-count":18,"title":["Hypothalamo\u2013pituitary\u2013adrenal axis, glucose metabolism and <scp>TNF<\/scp>\u2010<i>\u03b1<\/i> in narcolepsy"],"prefix":"10.1111","volume":"23","author":[{"given":"Eszter","family":"Maurovich\u2010Horvat","sequence":"first","affiliation":[{"name":"Department of Neurology and Center of Clinical Neuroscience First Faculty of Medicine and General University Hospital Charles University Prague Czech Republic"},{"name":"Centre of Mental Health Klinikum Ingolstadt Ingolstadt Germany"},{"name":"Max Planck Institute of Psychiatry Munich 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