{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T14:39:22Z","timestamp":1791383962840,"version":"4.3.3"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,9,5]],"date-time":"2014-09-05T00:00:00Z","timestamp":1409875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Cephalon GmbH, Germany"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Sleep Research"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>In 2010 the European Medicines Agency withdrew the indication of modafinil for the treatment of obstructive sleep apnea, shift work sleep disorder and for idiopathic hypersomnia (<jats:styled-content style=\"fixed-case\">IH<\/jats:styled-content>). In uncontrolled studies, modafinil has been reported to be efficacious in the treatment of sleep disorders. We therefore performed a randomized, placebo\u2010controlled study with the aim of proving the efficacy of modafinil treatment in these patients. Drug\u2010free <jats:styled-content style=\"fixed-case\">IH<\/jats:styled-content> patients without long sleep according to <jats:styled-content style=\"fixed-case\">ICSD<\/jats:styled-content>2 criteria, age &gt;18\u00a0years and disease duration &gt;2\u00a0years were included. After a washout phase, patients at baseline received placebo or 100\u00a0mg modafinil in the morning and at noon over 3\u00a0weeks, followed by 1\u00a0week without medication. At each visit the Epworth Sleepiness Scale (<jats:styled-content style=\"fixed-case\">ESS<\/jats:styled-content>) and Clinical Global Impression (<jats:styled-content style=\"fixed-case\">CGI<\/jats:styled-content>) rating scale were performed. At baseline and on days 8 and 21 four Maintenance of Wakefulness Tests (<jats:styled-content style=\"fixed-case\">MWT<\/jats:styled-content>s)\/day or per day were performed. Patients kept a sleep\u2013wake diary throughout the study. Between 2009 and 2011 three sleep centres recruited 33 participants. Compared to placebo, modafinil decreased sleepiness significantly and improved mean sleep latency in the <jats:styled-content style=\"fixed-case\">MWT<\/jats:styled-content> non\u2010significantly. The <jats:styled-content style=\"fixed-case\">CGI<\/jats:styled-content> improved significantly from baseline to the last visit on treatment. The most frequent adverse events were headaches and gastrointestinal disorders; skin and psychiatric reactions were not reported. The number of reported naps and duration of daytime sleepiness decreased significantly. Total sleep time of nocturnal sleep was slightly reduced. The sleep diaries showed increases in feeling refreshed in the morning; the diurnal diaries showed significant improvement of performance and of exhaustion. Modafinil is an effective and safe medication in the treatment of <jats:styled-content style=\"fixed-case\">IH<\/jats:styled-content>. Adverse events are mild to moderate.<\/jats:p>","DOI":"10.1111\/jsr.12201","type":"journal-article","created":{"date-parts":[[2014,9,5]],"date-time":"2014-09-05T10:14:40Z","timestamp":1409912080000},"page":"74-81","source":"Crossref","is-referenced-by-count":84,"title":["Modafinil in the treatment of idiopathic hypersomnia without long sleep time\u2014a randomized, double\u2010blind, placebo\u2010controlled study"],"prefix":"10.1111","volume":"24","author":[{"given":"Geert","family":"Mayer","sequence":"first","affiliation":[{"name":"Hephata Klinik Schwalmstadt\u2010Treysa Germany"},{"name":"Department of Neurology Philipps\u2010Universit\u00e4t Marburg Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heike","family":"Benes","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Rostock Rostock Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Young","sequence":"additional","affiliation":[{"name":"Department for Sleep Medicine and Neuromuscular Disorders University of M\u00fcnster M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Bitterlich","sequence":"additional","affiliation":[{"name":"Hephata Klinik Schwalmstadt\u2010Treysa Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Rodenbeck","sequence":"additional","affiliation":[{"name":"Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,9,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"crossref","first-page":"562","DOI":"10.5664\/jcsm.27658","article-title":"Idiopathic hypersomnia: clinical features and response to treatment","volume":"15","author":"Ali M.","year":"2009","journal-title":"J. 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