{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T17:19:13Z","timestamp":1773422353883,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,4,24]],"date-time":"2015-04-24T00:00:00Z","timestamp":1429833600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100015661","name":"UCB Pharma","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100015661","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Sleep Research"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Patients suffering from narcolepsy type 1 show altered skin temperatures, resembling the profile that is related to sleep onset in healthy controls. The aim of the present study is to investigate the effects of sodium oxybate, a widely used drug to treat narcolepsy, on the 24\u2010h profiles of temperature and sleep\u2010wakefulness in patients with narcolepsy and controls. Eight hypocretin\u2010deficient male narcolepsy type 1 patients and eight healthy matched controls underwent temperature measurement of core body and proximal and distal skin twice, and the sleep\u2013wake state for 24\u00a0h. After the baseline assessment, 2\u00a0\u00d7\u00a03\u00a0g of sodium oxybate was administered for 5 nights, immediately followed by the second assessment. At baseline, daytime core body temperature and proximal skin temperature were significantly lower in patients with narcolepsy (core: 36.8\u00a0\u00b1\u00a00.05\u00a0\u00b0C versus 37.0\u00a0\u00b1\u00a00.05\u00a0\u00b0C, <jats:italic>F<\/jats:italic>\u00a0=\u00a08.31, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.01; proximal: 33.4\u00a0\u00b1\u00a00.26\u00a0\u00b0C versus 34.3\u00a0\u00b1\u00a00.26\u00a0\u00b0C, <jats:italic>F<\/jats:italic>\u00a0=\u00a05.66, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.03). In patients, sodium oxybate administration increased proximal skin temperature during the day (<jats:italic>F<\/jats:italic>\u00a0=\u00a06.46, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.04) to a level similar as in controls, but did not affect core body temperature, distal temperature or distal\u2013proximal temperature gradient. Sodium oxybate administration normalised the predictive value of distal skin temperature and distal\u2013proximal temperature gradient for the onset of daytime naps (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.01). In conclusion, sodium oxybate administration resulted in a partial normalisation of the skin temperature profile, by increasing daytime proximal skin temperature, and by strengthening the known relationship between skin temperature and daytime sleep propensity. These changes seem to be related to the clinical improvement induced by sodium oxybate treatment. A causal relationship is not proven.<\/jats:p>","DOI":"10.1111\/jsr.12303","type":"journal-article","created":{"date-parts":[[2015,4,25]],"date-time":"2015-04-25T02:59:38Z","timestamp":1429930778000},"page":"566-575","source":"Crossref","is-referenced-by-count":12,"title":["The effects of sodium oxybate on core body and skin temperature regulation in narcolepsy"],"prefix":"10.1111","volume":"24","author":[{"given":"Astrid","family":"van der Heide","sequence":"first","affiliation":[{"name":"Leiden University Medical Centre Leiden the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire E. H. M.","family":"Donjacour","sequence":"additional","affiliation":[{"name":"Leiden University Medical Centre Leiden the Netherlands"},{"name":"SleepWake Centre SEIN Zwolle the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanno","family":"Pijl","sequence":"additional","affiliation":[{"name":"Leiden University Medical Centre Leiden the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert H. A. M.","family":"Reijntjes","sequence":"additional","affiliation":[{"name":"Leiden University Medical Centre Leiden the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastiaan","family":"Overeem","sequence":"additional","affiliation":[{"name":"Sleep Medicine Centre \u2018Kempenhaeghe\u2019 Heeze the Netherlands"},{"name":"Radboud University Medical Centre Nijmegen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gert J.","family":"Lammers","sequence":"additional","affiliation":[{"name":"Leiden University Medical Centre Leiden the Netherlands"},{"name":"SleepWake Centre SEIN Heemstede the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eus J. W.","family":"Van Someren","sequence":"additional","affiliation":[{"name":"Department of Sleep &amp; Cognition Netherlands Institute for Neuroscience Amsterdam the Netherlands"},{"name":"Departments of Integrative Neurophysiology and Medical Psychology Centre for Neurogenomics and Cognitive Research (CNCR) Neuroscience Campus Amsterdam, VU University and Medical Centre Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rolf","family":"Fronczek","sequence":"additional","affiliation":[{"name":"Leiden University Medical Centre Leiden the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,4,24]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"International Classification of Sleep Disorders \u2013 Third Edition (ICSD\u20103)","author":"American Academy of Sleep Medicine","year":"2014"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2006.01473.x"},{"key":"e_1_2_9_4_1","first-page":"23","article-title":"Effects of nocturnal gamma\u2010hydroxybutyrate on sleep\/waking patterns in narcolepsy\u2010cataplexy","volume":"7","author":"Broughton R.","year":"1980","journal-title":"Can. J. Neurol. Sci."},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjsm.2006.026344"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0644(98)70230-6"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(94)90110-4"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60237-2"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-10-0913"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00623.2010"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/07420528.2012.655869"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/29.11.1444"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2008.143610"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/31.2.233"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3109\/07420528.2010.504907"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-200412000-00002"},{"key":"e_1_2_9_17_1","volume-title":"The AASM Manual for the Scoring of Sleep and Associated Events: Rules, Terminology and Technical Specifications","author":"Iber C.","year":"2007"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(90)90581-5"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/43366"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.2000.278.3.R741"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.3109\/15563650.2011.576253"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/16.3.216"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/13.1.24"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2006.04.026"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-3057(97)00241-4"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsr.12253"},{"key":"e_1_2_9_27_1","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1093\/sleep\/6.2.137","article-title":"The 24\u2010hour rhythm core temperature in narcolepsy","volume":"6","author":"Mosko S. S.","year":"1983","journal-title":"Sleep"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)05582-8"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(94)90112-0"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpsycho.2013.01.001"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00492.2004"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2006.09.008"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm315"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/00063110-200602000-00011"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1177\/0748730410391894"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-011-1042-2"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/13.6.479"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1081\/CBI-100101050"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(06)53018-3"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00242275"}],"container-title":["Journal of Sleep Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjsr.12303","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjsr.12303","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jsr.12303","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T19:13:44Z","timestamp":1696274024000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jsr.12303"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,24]]},"references-count":39,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["10.1111\/jsr.12303"],"URL":"https:\/\/doi.org\/10.1111\/jsr.12303","archive":["Portico"],"relation":{},"ISSN":["0962-1105","1365-2869"],"issn-type":[{"value":"0962-1105","type":"print"},{"value":"1365-2869","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,24]]}}}